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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Newly designed proteins can effectively degrade specific proteins in cells, offering a promising alternative for targeted protein degradation.

Exosomal miR-222-3p reduces melanin production in rabbits by targeting the SOX10 gene.

Two new enzymes, PAD-R11 and PAD-R4, were cloned and showed activity, with PAD-R11 resembling epidermal enzymes.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

A woman with a rare type of dermatomyositis improved with low-dose prednisone and methotrexate.

Finasteride, a medication, is being re-evaluated for its effects and uses.

Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.

A new method helps detect androgen receptor movement in cells, aiding research on hair loss treatments.

A heart transplant patient developed a skin condition called epidermodysplasia verruciformis after taking immune-suppressing drugs.

Brodalumab is more effective than ustekinumab in treating psoriasis.

Mrp3 may aid in wound healing and hair growth.

Rab5c is crucial for blood stem cell development by regulating Notch and AKT signals.

Krt16-deficient mice help understand skin disorders like PC and FNEPPK.

Mrp3 helps in wound healing and hair growth.

A rare genetic variant linked to skin cysts was found in blood DNA, suggesting its role in cyst formation.

EP 2 receptor is essential for heart repair by helping macrophages work properly.

Deucravacitinib may effectively treat discoid lupus erythematosus.

5α-reductase 2 is crucial for stress response in male rats.

The M5 method is best for isolating cells that help hair growth.

DPP may help hair regrowth by improving blood vessel function under stress.

The polyG fragment in Hoxc13 protein helps evolve mammalian skin and hair by enhancing gene interactions.

Loss of Dnmt3a and Dnmt3b increases aggressive skin tumors by affecting PPAR-γ.

The balance between cell renewal and differentiation controls the growth of cancerous cells in mouse skin.

Standard treatment for congenital erythropoietic porphyria was ineffective over five years.

VDDR I and II are genetic disorders affecting vitamin D use, causing rickets, with VDDR I treatable by vitamin D supplements and VDDR II needing high doses and calcium.

Finasteride exposure harms tadpole reproduction and hormone balance.

Mutations in the enzyme don't significantly change how it binds to its specific substances.

Mutations in the KRT85 gene cause hair and nail problems.