110 citations
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August 2016 in “Drugs” Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.
105 citations
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August 2010 in “Pharmacology & therapeutics” Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
98 citations
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October 2012 in “Dermatologic Clinics” Eating the right nutrients can improve hair health, but taking extra supplements usually doesn't help unless you have a deficiency.
91 citations
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August 2024 in “Acta Pharmaceutica Sinica B” Microneedles can improve skin disease treatment by delivering drugs directly through the skin.
90 citations
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May 1972 in “Clinical Pharmacology & Therapeutics” Minoxidil quickly leaves blood, turns into urine metabolites, and has lasting blood pressure-lowering effects.
89 citations
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November 2014 in “International Journal of Nanomedicine” Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.
87 citations
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July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
87 citations
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September 2006 in “Clinical Cancer Research” Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.
86 citations
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October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
79 citations
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January 2017 in “Dermatology practical & conceptual” Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.
76 citations
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January 2022 in “Journal of Tissue Engineering” Microneedle patches could replace injections but need more development for better use in medicine.
76 citations
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August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
76 citations
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February 2007 in “Cancer Research” Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.
75 citations
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August 2008 in “PLOS ONE” Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.
72 citations
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January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
70 citations
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June 2010 in “Clinics in Dermatology” Certain groups may need vitamin supplements to improve hair health and prevent other health problems.
68 citations
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February 2011 in “European Journal of Pharmaceutics and Biopharmaceutics” Keratin films from human hair can potentially replace human nail plates for drug testing.
58 citations
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November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
56 citations
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January 2007 in “Pharmaceutical Development and Technology” Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.
56 citations
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February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
55 citations
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March 2014 in “EMBO Reports” Protein ubiquitylation is crucial for controlling stem cell functions and could be targeted for cancer treatment.
54 citations
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January 2013 in “BMC Complementary and Alternative Medicine” Thuja orientalis hot water extract may help hair grow by starting the growth phase and improving hair follicle development.
48 citations
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February 2025 in “Nano-Micro Letters” Microneedles offer a promising, painless way to treat skin diseases but need improvements for better use.
48 citations
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July 2023 in “Biomedicines” Hydrogel-forming microneedles are promising for safe, efficient, and controlled drug delivery through the skin.
44 citations
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June 2018 in “Journal of Cellular Physiology” Researchers developed a 3D model of human hair follicle cells that can help understand hair growth and test new hair loss treatments.
42 citations
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June 2021 in “Pharmaceutics” 3D printing can make microneedles for drug delivery faster and cheaper.
40 citations
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January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
39 citations
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August 2017 in “Colloids and Surfaces B: Biointerfaces” 50-nm nanoparticles are better at penetrating skin and targeting hair follicles for drug delivery than 100-nm ones.
36 citations
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February 2017 in “BMC Complementary and Alternative Medicine” Geranium sibiricum extract helps hair grow and is more effective than minoxidil but can be toxic in high concentrations.
33 citations
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December 2021 in “PLoS ONE” It's unclear which molecules best characterize dry skin due to inconsistent findings.