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Did you mean Receptor Activator of Nuclear Factor Kappa-Β Ligand?

GlossaryReceptor Activator of Nuclear Factor Kappa-Β Ligand

protein that promotes bone resorption by activating osteoclasts

Receptor Activator of Nuclear Factor Kappa-Β Ligand (RANKL) is a protein that plays a crucial role in bone metabolism by promoting the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. It is also involved in immune system regulation and has been linked to conditions such as osteoporosis and rheumatoid arthritis.

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Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

research RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

42 citations , December 2011 in “The journal of immunology/The Journal of immunology”

RANKL causes lymph nodes to grow by making certain cells multiply.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , July 2011 in “Stem Cells and Development”

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations , January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

research Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

21 citations , November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research XEDAR activates the non-canonical NF-κB pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

research The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances

4 citations , June 2025 in “Frontiers in Immunology”

BAFF-targeted therapies can reduce autoimmune disease activity, but more research is needed for precise treatments.

NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types

research NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types

23 citations , September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

NF-κB is crucial for different stages and types of hair growth in mice.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

207 citations , March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Androgens and androgen receptor action in skin and hair follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

1 citations , February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation

January 2025 in “Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)”

Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.

research Regulation of Semaphorin3A in the process of cutaneous wound healing

13 citations , March 2022 in “Cell Death and Differentiation”

Sema3A can both slow and speed up wound healing, depending on its form and combination with EGF.

research Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

86 citations , April 2016 in “Nature Communications”

Notch1 helps skin heal by attracting specific immune cells.

research Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases

December 2025

Plakophilin 1 helps control skin cell immune responses to prevent excessive inflammation.

Signaling by Senescent Melanocytes Hyperactivates Hair Growth

research Signalling by senescent melanocytes hyperactivates hair growth

27 citations , June 2023 in “Nature”

Senescent melanocytes can boost hair growth by activating hair stem cells.

research What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses

125 citations , August 2020 in “Frontiers in Immunology”

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

research Suppression of Cutibacterium acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

7 citations , March 2022 in “International Journal of Molecular Sciences”

FGF21 can help reduce skin inflammation caused by C. acnes.

research Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration

44 citations , June 2023 in “Cell Reports”

IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.

research Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

3 citations , October 2024 in “International Journal of Molecular Sciences”

CRET therapy affects inflammation in skin cells by changing cytokine levels and activating certain proteins.

research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation

November 2025 in “PLoS ONE”

Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.

Peroxisome Proliferator Activated Receptors Gamma Serum Levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case-Control Study

research Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study

July 2022 in “Research Square (Research Square)”

Lower PPARγ levels and specific gene variations are linked to more severe Frontal Fibrosing Alopecia.

research JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing

54 citations , July 2017 in “Scientific Reports”

JMJD3 and NF-κB activate Notch1, which is essential for skin cell movement and wound healing.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.