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The study presents the development of the TLMG hydrogel, a biointerface platform that forms in situ and adheres robustly to irregular skin wounds, offering enhanced mechanical properties and real-time signal monitoring for advanced wound management. By integrating tea polyphenols/lignin microspheres, the hydrogel combines bioelectronic and bioactive interfaces, achieving strong adhesion (200 kPa), high ionic conductivity (0.27 mS cm–1), and mechanical stability. Tested in complex animal models and human trials, the TLMG platform demonstrated intelligent wound management, dynamic signal monitoring, and improved wound healing through immunomodulatory mechanisms, highlighting its potential for wearable healthcare systems.

Proteolysis-Targeting Chimeras (PROTACs) have significantly transformed drug discovery by utilizing a unique catalytic degradation mechanism that targets and degrades specific proteins. This technology has progressed from a laboratory concept to achieving clinical breakthroughs, demonstrating its potential in treating various diseases. PROTACs offer advantages over traditional inhibitors by providing sustained protein degradation, which can lead to more effective and durable therapeutic outcomes. The development of PROTACs has opened new avenues for targeting previously "undruggable" proteins, marking a pivotal advancement in the field of medicinal chemistry and pharmacology.