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GlossarySAFE System

hair transplant technique involving simultaneous follicle extraction and implantation

The SAFE System is a hair transplant technique that stands for "Simultaneous Harvesting and Follicular Extraction." It involves extracting hair follicles from the donor area and implanting them into the recipient area in a synchronized manner, minimizing the time follicles spend outside the body. This method aims to improve graft survival rates and overall transplant outcomes.

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research Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness

37 citations , December 2020 in “Molecules”

A new delivery system makes Curcumin more effective and safer against viruses.

research Mesenchymal stem cells and their secretome - candidates for safe and effective therapy for systemic lupus erythematosus

6 citations , September 2021 in “Medical Journal of Cell Biology”

Mesenchymal stem cells and their secretome may offer a safe and effective treatment for systemic lupus erythematosus.

research Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A Critically Appraised Topic

12 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

Methotrexate's effectiveness for maintaining hair regrowth in alopecia totalis is unclear due to limited and biased data.

research ANDROGRAPHOLIDE LOADED TOPICAL NANOCARRIERS FOR MANAGEMENT OF PSORIASIS: A SAFE AND EFFECTIVE APPROACH

2 citations , January 2021 in “PLANT ARCHIVES”

Andrographolide-loaded topical nanocarriers are a safe and effective treatment for psoriasis.

research Isolated hyperthermic chemotherapy perfusion for limb melanoma is a safe procedure

July 2004 in “Journal of Clinical Oncology”

Isolated limb perfusion is a safe and effective treatment for limb melanoma.

New Methodology and Instrumentation for Follicular Unit Extraction: Lower Follicle Transection Rates and Expanded Patient Candidacy

research New Methodology and Instrumentation for Follicular Unit Extraction: Lower Follicle Transection Rates and Expanded Patient Candidacy

30 citations , June 2008 in “Dermatologic Surgery”

The SAFE System may improve hair transplant results but isn't suitable for everyone.

research New Methodology and Instrumentation for Follicular Unit Extraction

27 citations , January 2006 in “Dermatologic Surgery”

The SAFE System for hair transplants results in low damage to follicles and could make the procedure suitable for more patients.

Follicular Unit Extraction: Advances and Challenges

research Follicular unit extraction

1 citations , November 2009 in “Cambridge University Press eBooks”

FUE is a less invasive hair restoration method with potential to become standard, offering benefits like reduced scarring and pain, but requires experience to minimize risks.

research COMMENTARY

1 citations , January 2006 in “Dermatologic Surgery”

The SAFE System may reduce hair transplant transection rates but has been critiqued for not being as minimally invasive as claimed.

research A Look Back at Hair Restoration through History

January 2017 in “International journal of transplantation & plastic surgery”

Hair restoration techniques have improved over time, focusing on better results and less scarring, but skilled doctors are essential for natural-looking outcomes.

Literature Reviews on Cosmetic and Reconstructive Surgery

research Literature Reviews

June 2006 in “The American Journal of Cosmetic Surgery”

Advancements in cosmetic and reconstructive surgery improve techniques and patient satisfaction.

research HX09 A cut above: the hair-raising history of transplantation

June 2025 in “British Journal of Dermatology”

Hair transplantation has evolved significantly, becoming more effective and popular despite challenges.

research Safety Analysis of Panax Ginseng in Randomized Clinical Trials: A Systematic Review

47 citations , June 2015 in “Medicines”

Panax ginseng is generally safe with mild side effects and may have health benefits, but more research is needed.

research Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation

25 citations , February 2023 in “Aesthetic Surgery Journal”

Photobiomodulation is safe for skin rejuvenation, even for those with a cancer history.

research Platelet-Rich Plasma for Androgenetic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2 citations , August 2023 in “Journal of Cutaneous Medicine and Surgery”

PRP is effective and safe for increasing hair density in people with hair loss.

research Safety and Efficacy of Mesotherapy in the Treatment of Androgenetic Alopecia: A Systematic Review

2 citations , April 2017 in “Health technology assessment in action”

Mesotherapy seems safe and effective for hair loss, but more research is needed.

The Scalp as a Donor Site in Pediatric Burns: Systematic Review and Management Algorithm Proposal

research The Scalp as a Donor Site in Pediatric Burns: Systematic Review of the Literature and Proposal of a Management Algorithm

May 2026 in “European Burn Journal”

The scalp is a safe and effective donor site for skin grafts in children with burns.

research Efficacy and safety of oral minoxidil in the treatment of alopecia: a single-arm rate meta-analysis and systematic review

June 2025 in “Frontiers in Pharmacology”

Oral minoxidil is a safe and effective treatment for alopecia, improving hair growth with minor side effects.

research Systematic review of the evidence for medical skin needling in aesthetic practice

February 2017 in “Journal of Aesthetic Nursing”

Skin needling is a safe, effective, and affordable treatment for various skin issues and enhances other aesthetic procedures.

research Finasteride and sperm concentration: Rapid systematic review

October 2020 in “Journal of Pakistan Association of Dermatology”

Finasteride appears safe for long-term sperm concentration, but more research is needed for clear conclusions.

research Facial Feminization: Systematic Review of the Literature

157 citations , May 2016 in “Plastic and reconstructive surgery/PSEF CD journals”

Facial feminization surgery is safe and patients are satisfied, but more detailed research is needed.

research Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration

113 citations , July 2020 in “International Journal of Molecular Sciences”

Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.

research The efficacy and safety of JAK inhibitors for alopecia areata: A systematic review and meta-analysis of prospective studies

37 citations , August 2022 in “Frontiers in pharmacology”

Oral JAK inhibitors are effective and safe for treating alopecia areata but may need ongoing use to keep results.

research Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review.

32 citations , July 2016 in “PubMed”

5-alpha reductase inhibitors are generally safe but can cause sexual side effects and require patient education on risks.

research Systematic review of platelet‐rich plasma in treating alopecia: Focusing on efficacy, safety, and therapeutic durability

24 citations , January 2021 in “Dermatologic Therapy”

Platelet-rich plasma (PRP) is a safe and potentially effective way to treat hair loss, especially when combined with minoxidil.

research Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events

21 citations , December 2022 in “Pharmaceutics”

Laser-assisted drug delivery is generally safe with mostly mild side effects.

research Home-based devices in dermatology: a systematic review of safety and efficacy

9 citations , May 2021 in “Archives of Dermatological Research”

Home-based skin care devices are generally safe and effective for hair removal, promoting hair growth, treating wrinkles and acne, but results for psoriasis treatment are mixed.

research Systematic review: The platelet-rich plasma use in female androgenetic alopecia as effective autologous treatment of regenerative plastic surgery

5 citations , November 2021 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

Platelet-rich plasma is a safe and effective treatment for female hair loss.

research Adverse events in patients treated with Jak‐inhibitors for alopecia areata: A systematic review

2 citations , April 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

JAK-inhibitors for alopecia areata are generally safe with mostly mild side effects and a low rate of treatment withdrawal.

research Effect of Alexandrite Laser Hair Removal on the Activity of Systemic Lupus Erythematosus

March 2025 in “Mediterranean Journal of Rheumatology”

Laser hair removal is safe for people with Systemic Lupus Erythematosus.