168 citations
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August 2000 in “American Journal of Pathology” Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.
163 citations
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October 2001 in “EMBO journal” Overexpressing follistatin in mice delays wound healing and reduces scar size.
146 citations
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July 2018 in “Regenerative Medicine” Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
145 citations
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November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
128 citations
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August 2020 in “Cell stem cell” Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.
113 citations
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July 2015 in “Journal of Cosmetic Dermatology” Platelet-rich plasma may help with hair growth and skin quality but more research is needed to confirm its effectiveness.
109 citations
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December 2003 in “American Journal of Pathology” Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.
108 citations
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January 2023 in “Journal of Tissue Engineering” Scarless skin repair is possible by understanding and balancing wound healing mechanisms.
99 citations
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January 2002 in “Plastic & Reconstructive Surgery” Fetal rat wounds heal without scars at 16.5 days gestation.
89 citations
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March 1990 in “PubMed” Shaving is the most effective temporary hair removal method for facial hirsutism.
74 citations
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August 2023 in “Frontiers in Immunology” Fibroblasts are key to wound healing by managing immune cells and forming scar tissue.
65 citations
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June 2020 in “Stem Cell Research & Therapy” Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
60 citations
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June 2019 in “Ageing Research Reviews” Fat from the body can help improve hair growth and scars when used in skin treatments.
54 citations
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September 2012 in “Dermatologic Clinics” Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.
53 citations
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July 2018 in “Journal of cosmetic dermatology” Platelet-rich plasma may improve skin rejuvenation, hair growth, and scar treatment, but more large-scale trials are needed for stronger evidence.
48 citations
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March 2019 in “Frontiers in Physiology” Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.
48 citations
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May 2013 in “Canadian Medical Association Journal” Primary cicatricial alopecia, a rare disorder causing permanent hair loss, is hard to diagnose and treat, with treatments like anti-inflammatory drugs and steroids offering varied results and no guaranteed cure. Psychological support for patients is important, and future research should aim to identify causes of the condition.
44 citations
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April 2012 in “American Journal of Clinical Dermatology” Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
41 citations
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September 2017 in “Advanced Healthcare Materials” A special hydrogel helps heal skin without scars and regrows hair.
32 citations
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March 2014 in “PLOS ONE” Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.
32 citations
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January 2006 in “Acta dermato-venereologica” SACUMAN, a rare condition causing hair loss without clear signs, is often misdiagnosed and needs scalp biopsies for accurate detection.
31 citations
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December 2022 in “Cold Spring Harbor Perspectives in Biology” Understanding cell transitions can lead to better wound healing treatments.
31 citations
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January 2019 in “Frontiers in Veterinary Science” Laser therapy improved surgical scar healing in dogs.
31 citations
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March 2009 in “Archives of Facial Plastic Surgery” The hairline-lowering surgery was effective, safe, and left patients satisfied with few complications.
28 citations
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August 2018 in “Dermatologic Surgery” Platelet-Rich Plasma (PRP) may help improve hair density in primary cicatricial alopecias (PCAs) patients, but more trials are needed to confirm its benefits.
28 citations
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July 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery” A patient had skin tissue death at the hair removal site after a hair transplant, which was treated with surgery.
28 citations
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January 2000 in “Dermatologic Therapy” Laser treatments can greatly improve the look of scars and stretch marks.
27 citations
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July 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Lasers have become precise tools in skin treatment and diagnosis, with ongoing advancements improving their effectiveness.
26 citations
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July 2007 in “Wound Repair and Regeneration” MRL/MpJ mice heal burns slower with more scarring and less tissue regeneration than BALB/c mice.
25 citations
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September 2014 in “Dermatologic Surgery” Hair transplants can effectively treat hair loss from CCCA in African American women if there's no inflammation.