September 2024 in “Health Problems of Civilization” Isotretinoin effectively treats severe acne but has significant side effects requiring careful monitoring.
June 2023 in “International Journal of Research in Dermatology” Certain gene variations are linked to severe acne in Egyptian patients and could guide treatment choices.
December 2020 in “Benha Journal of Applied Sciences” People with severe acne tend to have higher levels of betatrophin.
14 citations
,
March 2022 in “Clinical Endocrinology” The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).
29 citations
,
January 2007 in “Dermatologic Clinics” Photodynamic Therapy is an effective treatment for mild to severe acne.
8 citations
,
April 2024 in “Cureus” CO2 lasers are better for severe acne scars, while Er:YAG lasers are gentler with fewer side effects.
2 citations
,
January 2014 in “Springer eBooks” Polycystic Ovary Syndrome (PCOS) often leads to severe acne, and lifestyle changes and hormonal treatments can help manage it.
Higher apelin-12 levels may indicate more severe acne.
October 2020 in “Benha Journal of Applied Sciences” Lower vaspin levels are linked to more severe acne and higher insulin resistance.
46 citations
,
September 2016 in “Clinical, Cosmetic and Investigational Dermatology” Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.
Low-dose sorafenib can cause severe facial acne, treatable with topical medication.
December 2010 in “Zanco Journal of Medical Sciences” Acne is more common and severe in females, often with pre-menstrual flare-ups and associated with seborrhea.
20 citations
,
April 2020 in “Journal of advanced Biomedical and Pharmaceutical Sciences” Niosomal methylene blue gel effectively improves moderate to severe acne.
12 citations
,
May 2017 in “Medicine” Oral isotretinoin was recommended for a 21-year-old woman with severe acne.
11 citations
,
February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.
4 citations
,
April 2016 in “Journal of Dermatology Research and Therapy” Anti-androgens are safe and effective for treating moderate to severe adult female acne.
1 citations
,
March 2022 in “Cureus” A woman with lupus and systemic sclerosis developed severe acne that didn't improve with treatment and died from pneumonia and septic shock.
December 2022 in “Cureus” Adult women with acne in Iraq often have more severe symptoms and hormone-related issues than younger girls with acne.
31 citations
,
June 2015 in “British Journal of Dermatology” Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.
July 2025 in “Canadian Family Physician” Use topical treatments for mild acne and oral treatments for moderate to severe acne, avoiding antibiotic monotherapy.
Isotretinoin and other medications showed promising results for treating a rare scalp condition linked to severe acne.
January 2013 in “Xiandai shengwu yixue jinzhan” Finasteride effectively treats acne, especially severe cases, with low recurrence rates.
21 citations
,
April 2011 in “Clinical Cosmetic and Investigational Dermatology” Acne treatment varies by severity, using topical treatments for mild cases, combination therapies for moderate cases, and oral isotretinoin for severe cases, with hormonal treatments for some women.
September 2024 in “Research Square (Research Square)” Many North African women with acne also have PCOS, showing more severe symptoms and higher testosterone levels.
The medicine Diane is effective in treating hair loss, severe acne, and excessive hair growth.
463 citations
,
September 2004 in “Clinics in dermatology” Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.
30 citations
,
December 2001 in “Journal of The European Academy of Dermatology and Venereology” Hormonal therapy is a good option for women with severe acne, especially when there's a chance of hormone imbalance.
8 citations
,
May 1998 in “Journal of Oral and Maxillofacial Surgery” Acne is caused by increased sebum, abnormal skin shedding, bacteria, and inflammation, not dirt; treatments vary from creams to antibiotics or isotretinoin, with severe cases needing a dermatologist's care.
78 citations
,
June 1989 in “The Journal of dermatologic surgery and oncology” Acne keloidalis is a chronic skin condition on the back of the neck in young black men, needing surgery for severe cases.
April 2019 in “Journal of the Endocrine Society” A woman's severe male-like symptoms were caused by a rare, benign tumor in her ovary that produced male hormones.