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GlossarySkin Thickening

process where skin becomes thicker due to chronic irritation

Skin thickening, also known as lichenification, refers to the process where the skin becomes thicker and leathery due to chronic inflammation or repeated irritation. This condition often results from persistent scratching or rubbing, leading to an exaggerated skin cell production and a more pronounced skin texture. It is commonly seen in conditions like eczema or chronic dermatitis.

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Morphological Analysis of Patchy Thickening and Reddish Discoloration of Active Hair Growth Areas in the Skin of New Zealand White Rabbits

research Morphological analysis of patchy thickening and reddish discoloration of active hair growth areas in the skin of New Zealand White rabbits

6 citations , January 2017 in “Journal of toxicologic pathology”

Rabbit skin with active hair growth shows thicker, redder areas due to larger, more numerous hair follicles and increased blood vessels.

research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits

2 citations , May 2024 in “BMC Genomics”

Certain genetic changes in the KRT82 gene may cause patchy skin in New Zealand rabbits.

research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

252 citations , November 1995 in “The EMBO Journal”

Blocking EGFR in mice causes hair loss and skin changes.

research Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

201 citations , May 2001 in “Proceedings of the National Academy of Sciences”

Overexpression of COX-2 in mice skin causes abnormal skin and hair development.

research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis

148 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice without the vitamin D receptor are more prone to UV-induced skin tumors.

research Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

135 citations , December 2006 in “PLoS Medicine”

Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.

research RASopathic Skin Eruptions during Vemurafenib Therapy

82 citations , March 2013 in “PLoS ONE”

Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.

research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

81 citations , February 2014 in “EMBO molecular medicine”

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

research Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig.,

45 citations , August 1954 in “Experimental Biology and Medicine”

Vitamin A penetrates guinea pig skin quickly in alcohol, affects skin thickness, but doesn't impact hair growth.

research Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

35 citations , January 2011 in “Journal of Biological Chemistry”

sPLA2-X is crucial for normal hair growth and follicle health.

research Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation

28 citations , June 1995 in “The Journal of Dermatology”

The flaky skin mouse mutation is a natural model for studying human psoriasis.

research Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

22 citations , December 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

A mouse gene mutation increases the risk of skin cancer.

research Epidermal dysplasia and Malassezia infection in two West Highland White Terrier siblings: an inherited skin disorder or reaction to severe Malassezia infection?

17 citations , October 2001 in “Veterinary dermatology”

The skin issues in the two dogs might be caused by infection or self-injury, not genetics.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations , June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

research miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades

15 citations , November 2024 in “Journal of Advanced Research”

miR-3606-3p reduces skin fibrosis by blocking key signaling pathways.

research Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin.

12 citations , February 1986 in “PubMed”

Injecting newborn mice with a niacin blocker caused skin, gut, and brain damage similar to human pellagra.

research Antigen presenting cells in the skin of a patient with hair loss and systemic lupus erythematosus.

9 citations , September 2009 in “PubMed”

Antigen presenting cells around hair follicles are crucial in SLE-related hair loss.

research Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats.

7 citations , January 2002 in “PubMed”

Prolonged UVB exposure causes significant skin changes and damage in rats.

research Wound healing mechanism in Mongolian gerbil skin

6 citations , November 2018 in “Histochemistry and Cell Biology”

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

research Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

5 citations , January 2021 in “Frontiers in cell and developmental biology”

Skin cysts might help advance stem cell treatments to repair skin.

research Tracing the Change and Contribution of Subcutaneous Adipose to Skin Expansion Using a Luciferase-Transgenic Fat Transplantation Model

4 citations , May 2023 in “Plastic & Reconstructive Surgery”

Adipose tissue helps skin expand by increasing blood vessels and cell growth.

research Correction: RASopathic Skin Eruptions during Vemurafenib Therapy

4 citations , October 2013 in “PLoS ONE”

Vemurafenib causes significant skin side effects, requiring regular dermatologist care and sun protection.

research Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis due to Sarcoptes scabiei

2 citations , February 2021 in “Journal of comparative pathology”

Sheep with chronic Sarcoptes scabiei dermatitis have altered keratin expression in their skin.

Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology

research Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation.

March 2020 in “The Egyptian Journal of Histology”

Topical olive oil protects mice skin from harmful electromagnetic radiation.

research 915 Dietary grape powder inhibits atopic dermatitis-like skin lesions in NC/Nga mice

April 2019 in “Journal of Investigative Dermatology”

Eating grape powder may reduce the severity of skin allergy symptoms.

Congenital and Hereditary Skin Diseases in Bovines

research Congenital and Hereditary Skin Diseases

January 2018

Bovines can have rare inherited skin diseases with specific symptoms like hair loss, fragile skin, and abnormal porphyrin buildup.