research Hormonal and Genetic Controls of Hirsutism: Link Between hyperprolactinemia, Polycystic ovary syndrome and Hirsutism
Hormones, genes, and oxidative stress interact to cause hirsutism and PCOS.
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research Toxic epidermal necrolysis caused by etonogestrel implantation: A rare presentation
A woman developed a severe skin reaction after getting a birth control implant.
research Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter.
Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.
research Adrenal and Gonadal Activity, Androgen Concentrations, and Adult Height Outcomes in Boys With Silver-Russell Syndrome
Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.
research Targetoid Polycyclic Concentric Hair Regrowth Pattern Is a Sign of Immunological Recovery in Alopecia Areata
A targetoid hair regrowth pattern indicates recovery in alopecia areata.
research Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men
The Free Androgen Index (FAI) is the best indicator of early hair loss in men before age 30.
research Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators
Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.
research The hair growth effect of minoxidil
Minoxidil promotes hair growth by increasing blood flow and directly affecting hair follicles.
research Minoxidil e óleo essencial de alecrim: proposta de solução tópica para alopecia androgenética
This study explores a topical solution combining 5% minoxidil sulfate and 1% rosemary essential oil for treating androgenetic alopecia (AAG), a leading cause of hair loss. Minoxidil is known for promoting hair growth by enhancing peripheral vasodilation and extending the anagen phase, while rosemary oil offers antioxidant and anti-inflammatory benefits for scalp health. Two formulations with different vehicle compositions were developed, both showing suitable physicochemical properties and homogeneity, indicating potential as a compounded treatment for AAG. The vehicle type did not affect the outcome. Further accelerated stability studies and clinical trials are recommended to confirm the therapeutic efficacy and safety of this combination.
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
Bubble microneedles effectively deliver drugs through the skin and mouth, improving treatment speed and efficiency.
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
Bubble microneedles effectively deliver drugs through skin and mouth, improving hair growth and lowering glucose.
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
This study introduces a finite element analysis (FEA)-guided framework for designing separable bubble microneedles (BMNs) that optimize geometry and cavity parameters for controlled tip separation and robust insertion. The study tested minoxidil sulfate-loaded BMNs (MXS-BMNs) and insulin-loaded BMNs (INS-BMNs) for transdermal and sublingual delivery, respectively. The BMNs demonstrated effective payload release, with over 80% liberated within 10 minutes. In ex vivo tests, MXS-BMNs showed significantly higher minoxidil permeation compared to topical gel, and in vivo tests on mice showed accelerated hair regrowth. INS-BMNs effectively lowered glucose levels in diabetic rats, comparable to subcutaneous injections. This approach reduces empirical iteration, facilitating the development of efficient microneedle systems for rapid drug delivery.
research Quality of Life in Polycystic Ovary Syndrome after Anti-Androgen Therapy Using PCOSQOL-47 and PCOSQOL-42
Combined finasteride and spironolactone therapy significantly improves quality of life in women with PCOS.
research Reprogramming Wound Healing: GAG ‐Based Bioactive Scaffold Drives Pro‐Regenerative Cellular Cross‐Talk
The scaffold improves wound healing and tissue regeneration.
research Rethinking Oral Minoxidil: Distinguishing the Hair-Growth Window from the Cardiovascular Threshold
Lower doses of oral minoxidil can promote hair growth without major heart risks.
research Cutaneous Manifestations and Their Relationship with Serum Testosterone and DHEAS Levels in Women with Polycystic Ovary Syndrome: A Cross‑Sectional Clinical Study
Hirsutism and acne indicate high androgen levels in women with PCOS, suggesting early treatment can help.
research Combined Regenerative Technique: Tattoo Machine–Assisted Drug Delivery for Androgenetic Alopecia
Tattoo machine-assisted drug delivery may improve hair growth in androgenetic alopecia.
research Valorization of mangosteen (Garcinia mangostana L) waste as green hair dyeing pigment: Effect of mordant and formula optimization
Mangosteen waste can be used as an eco-friendly natural hair dye, producing a lasting reddish color and strengthening hair.
research Male polycystic ovarian syndrome phenotype: a meta-analysis of endocrine-metabolic dysregulation in fathers and brothers of PCOS-affected women
Male relatives of women with PCOS show similar health issues, suggesting a male version of the condition.
research SAT-478 Virilizing Adrenal Adenoma Co-secreting Cortisol and DHEA-S: A Case Report
Surgery improved symptoms and normalized hormone levels in a woman with an adrenal tumor.
research Zinc-responsive Acral Hyperkeratosis as a Sequele of Acrodermatitis Enteropathica
Zinc treatment improved skin and hair issues in a boy with a zinc-related condition.
research Pattern of Hyperandrogenemia in Patients with Polycystic Ovary Syndrome at a Tertiary Care Hospital
Free testosterone is the most common hormone marker in PCOS, and age affects DHEAS levels.
research Assessment of polycystic ovary syndrome (PCOS) occurrences among adolescent and young reproductive age group women in Tiruchirappalli District
Women aged 21-26 have a higher rate of PCOS.
research Premature isolated adrenarche in a six-year-old girl
A six-year-old girl has early signs of puberty, needs no treatment, but requires regular check-ups for future health risks.
research AYURVEDIC MANAGEMENT OF INDRALUPTA (ALOPECIA AREATA) –CASE REPORT
Ayurvedic treatment effectively improved alopecia areata symptoms quickly and affordably.
research The Serum Evaluation of Sex Hormones Including DHEAs, DHT, Testosterone in Oral Lichen Planus Patients
Oral lichen planus is not linked to sex hormone levels.
research Diagnosis of polycystic ovaries syndrome: establishment of reference values of nine hormones on Maglumi X- 8
Reference values for nine hormones were established to help diagnose PCOS.
research Assessment of androgenic hormones and other risk factors in Egyptian males with early onset androgenetic alopecia: a case control study
Early-onset hair loss in Egyptian males is linked to genetics, hormones, and lifestyle factors like smoking and diet.
research Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study
Myo-inositol with magnesium effectively reduces acne and hirsutism in PCOS patients without side effects.
research Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients
Patch testing is crucial to reduce allergic reactions in hair loss treatments.