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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Raltitrexed conjugates are less potent than the free drug but more effective at high concentrations.

A 7-year-old girl was diagnosed with trichothiodystrophy due to low sulfur levels in her hair.

Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.

Lack of TG2 increases fat storage and lowers cell cleanup in skin oil cells.

PFOS exposure disrupts hormone levels and enzyme activities in juvenile frogs, affecting males and females differently.

New tests detect finasteride and dutasteride in urine quickly and easily.

Skin tumor cells in patients with tuberous sclerosis have higher levels of a protein called cathepsin B.

Transglutaminase 2 may control sebocyte maturation and lipid metabolism.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Finasteride may help reduce symptoms in male Tourette syndrome patients.

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

SPET-085 effectively inhibits an enzyme linked to prostate issues, similar to finasteride.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

Mercaptans make hair more prone to damage, with reduced hair being more affected than permed hair.

New method accurately measures finasteride in medicine using NQS.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Lowering homocyst(e)ine levels can reverse skin and hair lightening by restoring enzyme activity needed for pigmentation.

Sodium metabisulfite increases sodium channel activity, leading to higher cell excitability and potential damage.

Method accurately measures finasteride in tablets using finasteride-BSA interaction.

Some prostate cancers have gene changes that may affect treatment with certain drugs.

The method effectively measures drug impact on DHT levels in prostate treatments.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Superoxide dismutases help balance cell stress and may aid cancer treatment.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Aspergillus niger culture creates two finasteride derivatives with enzyme-inhibiting effects.

New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.