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Supplementary Material For: Tofacitinib In Overlapping Autoimmune And Autoinflammatory Disorders: A Case Report Of A Dual Graham-Little-Piccardi-Lasseur Syndrome And Hidradenitis Suppurativa

research Supplementary Material for: TOFACITINIB IN OVERLAPPING AUTOIMMUNE AND AUTOINFLAMMATORY DISORDERS: A CASE REPORT OF A DUAL GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME AND HIDRADENITIS SUPPURATIVA

April 2026 in “Figshare”

Tofacitinib significantly improved hair loss and lesions in a patient with overlapping autoimmune disorders.

research The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

research Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

2 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Impaired LEF1 activation speeds up skin cell development in Hutchinson-Gilford Progeria Syndrome.

research Finasteride.

January 2011 in “Bloomsbury Academic eBooks”

research Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

24 citations , July 2017 in “Structure”

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

Risk Factors, Prevalence, and Diagnosis of Hutchinson-Gilford Syndrome with Special Reference to Case Reports

research RISK FACTORS, PREVALENCE AND DIAGNOSIS OF HUTCHISON GILFORD SYNDROME WITH SPECIAL REFERENCE TO CASE REPORTS

2 citations , May 2017 in “International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences”

Hutchinson-Gilford Progeria Syndrome is a rare genetic disorder caused by a specific gene mutation, characterized by aging symptoms and managed by monitoring heart health and using low-dose aspirin.

research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System

16 citations , April 2000 in “Journal of Investigative Dermatology”

The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.

research 455 Beyond Immunity: TEC and JAK3 Kinase Activation in Melanocytes Drives Inflammation in Vitiligo

November 2025 in “Journal of Investigative Dermatology”

TEC kinases may help cause inflammation in vitiligo and could be targeted for treatment.

research A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β

5 citations , June 2022 in “Biophysical Journal”

TGF-β and TNF influence hair follicle cell fate, with TNF being more effective in triggering cell death.

Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment

August 2019 in “Research Square (Research Square)”

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.

research The Peach RGF/GLV Signaling Peptide pCTG134 Is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions

9 citations , October 2017 in “Frontiers in plant science”

The peach gene CTG134 helps control the interaction between auxin and ethylene, which could lead to new agricultural chemicals.

research Structural Transition of Trichocyte Keratin Intermediate Filaments During Development in the Hair Follicle

7 citations , January 2017 in “Sub-cellular biochemistry/Subcellular biochemistry”

Case Report: Diffuse Hypertrichosis in the Course of Hepatitis C Treatment by IFN-Alpha and Ribavirin

research Case Report: Diffuse Hypertrichosis in the Course of Hepatitis C Treatment by IFN-αi> and Ribavirin

16 citations , August 2002 in “Journal of Interferon and Cytokine Research”

A man developed excessive hair growth after treatment with interferon-alpha and ribavirin for hepatitis C.

research Male pattern hair loss - rh79g
December 2025 in “ILDS-DEV”

research Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse
1 citations , August 2014 in “Asian-Australasian Journal of Animal Sciences”

Recombinant goat VEGF164 speeds up hair growth in mice.

research Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome
1 citations , May 2022 in “International journal of molecular sciences”

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

research A pilot study of 2% tofacitinib cream with narrowband ultraviolet B for the treatment of facial vitiligo
25 citations , April 2019 in “Journal of The American Academy of Dermatology”

Using 2% tofacitinib cream with narrowband ultraviolet B improved facial vitiligo by 70% in patients who didn't respond to previous treatments, with no side effects reported.

research Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling
1 citations , December 2012 in “Journal of Dermatological Science”

FGF18 controls hair growth rest phase.

research Versatility of autologous growth factor concentrate therapy in early-stage androgenetic alopecia: A case report
October 2025 in “Asian Journal of Oral Health and Allied Sciences”

Autologous growth factor concentrate therapy shows promise for treating early-stage hair loss safely and effectively.

research 8483 Changes in kidney hemodynamics during gender-affirming hormone therapy in transgender individuals - findings from the KNIGHT pilot study
October 2024 in “Journal of the Endocrine Society”

Feminizing hormone therapy increases kidney filtration rate.

research Molecular studies of Hutchinson-Gilford progeria syndrome
May 2009 in “OPAL (Open@LaTrobe) (La Trobe University)”

Suppressing the HGPS mutation may improve symptoms and suggest reversibility.

research Filtration of Transgenic Sheep Skin Fibroblasts with KAP6.1-GFP-polymerized Spider Dragline Silk Protein Gene(4S)
January 2011 in “Zhongguo nongye Kexue”

Transgenic sheep cells with spider silk gene were successfully created for future sheep hair expression.

research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.
11 citations , January 1992 in “PubMed”

TGF-beta 1 and IGF-II mRNA have specific patterns in pig subcutaneous tissue, affecting fat and muscle development.

research Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding
237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research 1391 Immune cells may have a role in hair loss process caused by TRPV3 gain-of-function mutation
April 2018 in “Journal of Investigative Dermatology”

Immune cells might contribute to hair loss caused by a specific mutation.

research 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis
November 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after wounds.

research Loss of PIKFyve Kinase Function Driven by Platelet Factor 4 Promoter Results in Platelet Lysosomal Storage Defects and Infiltration of Multiple Organs with Vacuolated Macrophages
November 2011 in “Blood”

PIKFyve is essential for normal platelet function and its deficiency causes organ issues and macrophage infiltration.

research Tofacitinib in alopecia areata and HIV: A curious intersection of immunomodulation, hair regrowth, and hypertrichosis
February 2025 in “International Journal of STD & AIDS”

Tofacitinib can cause unusual hair growth, requiring careful monitoring and possible laser hair removal.

research In Memoriam
November 2025 in “International Society of Hair Restoration Surgery”

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