96 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
3 citations
,
May 2022 in “Oncogene” Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
2 citations
,
September 2017 in “Archives of Medical Science” Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.
2 citations
,
February 2023 in “Transgenic Research” The E2 protein affects gene activity in hair follicles of mice.
19 citations
,
December 2016 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.
April 2026 in “Cellular and Molecular Immunology” SPT6 prevents excessive skin inflammation by blocking a feedback loop.
106 citations
,
September 2010 in “Stem cells” Skin-derived precursors in hair follicles come from different origins but function similarly.
63 citations
,
May 2011 in “Clinical cancer research” The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
55 citations
,
November 2018 in “American journal of human genetics” Mutations in the LSS gene cause a rare type of hereditary hair loss.
52 citations
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September 2020 in “Cell Death and Disease” Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.
43 citations
,
December 2008 in “Molecular biology of the cell” Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.
35 citations
,
July 2018 in “Cell Reports” The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.
21 citations
,
March 2018 in “Experimental Dermatology” The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.
19 citations
,
September 2019 in “EMBO molecular medicine” Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.
15 citations
,
May 2023 in “npj Regenerative Medicine” Macrophages help maintain mammary stem cells and tissue balance through specific signaling pathways.
14 citations
,
January 2024 in “Theranostics” Intranasal delivery of gene therapy shows promise for treating ischemic stroke.
11 citations
,
October 2018 in “Nucleic Acid Therapeutics” Modified KGF mRNA helps skin cells grow and move faster, which may improve wound healing.
11 citations
,
October 2016 in “Biomedicine & Pharmacotherapy” Both human platelet lysate and minoxidil can promote hair growth, but they affect different genes and cell survival rates.
10 citations
,
January 2014 in “Journal of prosthodontic research” Bioengineered salivary glands in mice can produce saliva when tasting sour or bitter, but have different protein levels and nerve signals compared to natural glands.
3 citations
,
February 2021 in “Molecules” A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.
A stem cell-derived matrix speeds up healing of diabetic skin wounds.
Lack of certain cells causes abnormal nipple development and nursing failure.
Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.
The treatment was ineffective in humans.
September 2022 in “Research Square (Research Square)” Macrophages help maintain mammary stem cells and balance through specific signaling.
218 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
35 citations
,
January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” CD98hc's role in skin health decreases with age.
Minoxidil and nebivolol can help prevent aortic aging in diabetic mice.
417 citations
,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
137 citations
,
October 2009 in “The American journal of pathology” Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.