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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Loss of Dnmt3a and Dnmt3b increases aggressive skin tumors by affecting PPAR-γ.

Alloxan diabetes, methylthiouracil, cortisone, and adrenaline affect how white mice hair follicles use glucose and cystine and their cell division.

Platinum-based chemotherapy drugs can cause many severe side effects, often requiring dose reductions and additional medications to manage.

The drug TGU was ineffective against small cell lung cancer and caused significant bone marrow suppression.

Docetaxel is effective against various cancers but mainly causes neutropenia.

The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.

Finasteride may help treat childhood brain tumors by activating certain genes.

Methotrexate with corticosteroids can help regrow hair in severe alopecia areata but may cause relapses and side effects.

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

Mycophenolate mofetil is safer and more effective than cyclophosphamide for treating lupus nephritis.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Tebentafusp-tebn improves survival rates in uveal melanoma patients but has common side effects like rash and fatigue.

TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.

Mitotane changes steroid breakdown, affecting cortisol availability.

Thymectomy and high-dose prednisolone improved hair loss in a woman with alopecia areata.

A chemical called 5-Bromo-2′-deoxyuridine caused rapid hair loss in mice by killing certain skin cells through a specific cell death pathway.

Sacituzumab tirumotecan shows promise in treating breast cancer with manageable side effects.

Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.

TS-13 effectively stops tumor growth and reduces chemotherapy side effects.

Chemotherapy reduces splenic melanin in mice.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Certain medications, like trimethoprim, can cause aseptic meningitis, especially in people with autoimmune conditions.

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

PPARγ signaling modulation can protect hair follicle stem cells from chemotherapy-induced damage.

Methotrexate effectively treated a 2-year-old's generalized pustular psoriasis without side effects.

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.