March 2026 in “Frontiers in Bioengineering and Biotechnology” Stem cell-derived fibroblasts can effectively repair skin wounds.
January 2011 in “Journal of Tissue Engineering and Reconstructive Surgery” Using dermal papillae cells and keratinocytes in skin substitutes speeds up healing and helps form hair follicles and glands.
12 citations
,
September 2020 in “Stem cell research & therapy” Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.
July 2025 in “Journal of Investigative Dermatology” Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.
April 2021 in “Journal of Investigative Dermatology” Early-stage skin substitutes improve wound healing and skin structure.
41 citations
,
June 2013 in “PLOS ONE” Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.
11 citations
,
March 2023 in “Stem Cell Research & Therapy” Epidermal stem cells improve skin graft survival by promoting early blood vessel formation.
1 citations
,
July 2025 in “Scientific Reports” CD133+ cells are crucial for hair growth.
7 citations
,
January 2019 in “Methods in molecular biology” Engineered skin with hair follicles can improve burn treatments.
15 citations
,
April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
4 citations
,
October 2017 in “Advances in tissue engineering & regenerative medicine” Researchers created a potential skin substitute using a biodegradable mat that supports skin cell growth and layer formation.
28 citations
,
September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
192 citations
,
January 2018 in “Burns & Trauma” Current skin substitutes help heal severe burns but don't fully replicate natural skin features.
57 citations
,
July 2018 in “Scientific Reports” Using adipose tissue-derived fragments improves early skin graft success.
11 citations
,
January 2025 in “Regenerative Therapy” Tissue-engineered scaffolds help heal difficult wounds by supporting cell growth and repair.
84 citations
,
June 2013 in “Stem Cells Translational Medicine” New methods for skin and nerve regeneration can improve healing and feeling after burns.
5 citations
,
March 2024 in “Frontiers in Bioengineering and Biotechnology” A detailed 3D model of human skin was created to help develop artificial skin.
11 citations
,
February 2022 in “Scientific Reports” CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.
83 citations
,
January 2015 in “World Journal of Stem Cells” Hair follicle regeneration needs special conditions and young cells.
45 citations
,
October 2014 in “Stem cell research & therapy” Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.
February 2026 in “BMC Plastic and Reconstructive Surgery” Induced pluripotent stem cells could improve chronic wound healing but face safety and effectiveness challenges.
3 citations
,
August 2011 in “InTech eBooks” The document concludes that skin grafts are essential for repairing tissue loss, with various types available and ongoing research into substitutes to improve outcomes and reduce donor site issues.
71 citations
,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
12 citations
,
January 2009 in “Stembook” Improved understanding of stem cell mechanisms can enhance skin tissue engineering.
August 2019 in “Stem cells” New treatments for hair loss, fertility, and wound healing are being explored.
Tissue from dog stem cells helped grow hair in mice.
2 citations
,
May 2023 in “Frontiers in Bioengineering and Biotechnology” The document concludes that more research is needed on making and understanding biomaterial scaffolds for wound healing.
16 citations
,
August 2019 in “Journal of the Chinese Medical Association” Stem cell therapy could improve burn healing but has challenges to overcome.
3D culture better preserves sweat gland cell identity than 2D culture.
24 citations
,
October 2010 in “Tissue Engineering Part A” Tissue-engineered skin can support hair growth after grafting, especially with mouse-derived dermis.