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GlossaryTopical Antiandrogens

medications applied to skin to block androgen effects locally

Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques

research Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques

18 citations , January 1998 in “Endocrine”

RU58841, a nonsteroidal anti-androgen, showed potential as a topical treatment for hair loss, increasing hair density, thickness, and length without systemic side effects in Stumptailed Macaques.

research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

49 citations , January 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

RU 58841 may treat acne, hair loss, and excessive hair growth.

Reversal of Androgenetic Alopecia by Topical Ketoconazole: Relevance of Anti-Androgenic Activity

research Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity

38 citations , September 2006 in “Journal of Dermatological Science”

Ketoconazole lotion can improve hair regrowth for some people with androgenetic alopecia.

research New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice

37 citations , January 2000 in “International Journal of Pharmaceutics”

Topical treatments can regrow hair on bald scalps.

research Topical Antiandrogens

11 citations , January 1985 in “Archives of Dermatology”

Topical antiandrogens might treat skin issues like hair growth, balding, and acne, but finding effective treatments without side effects is challenging.

research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

9 citations , January 2017 in “Organic Process Research & Development”

In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.

research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

7 citations , December 2019 in “American Journal of Clinical Dermatology”

Topical therapies show promise for hair loss and acne treatment with minimal side effects.

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

April 2012 in “Journal of the American Academy of Dermatology”

Clofazimine may be effective for treating ashy dermatosis.

research Topical antiandrogens in the treatment of male-pattern baldness

10 citations , October 1988 in “Clinics in dermatology”

Topical antiandrogens might be a good option for male-pattern baldness with fewer side effects, but more research is needed to confirm their safety and effectiveness.

research Topical antiandrogens. What use in dermatology?

5 citations , January 1985 in “Archives of Dermatology”

Skin creams that block male hormones may help with hair growth, hair loss, and acne.

research Clascoterone: a new topical antiandrogen agent.

February 2025 in “Prospects in Pharmaceutical Sciences”

Clascoterone is a promising topical treatment for hair loss and acne with fewer side effects.

research Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster

26 citations , January 1987 in “Archives of Dermatology”

Topical minoxidil does not block androgen effects.

research 0951 Breezula, a clinical stage topical anti-androgen, promotes dermal papilla inductivity and reduces IL-6 secretion in balding skin samples ex vivo

July 2025 in “Journal of Investigative Dermatology”

Breezula® may be more effective than Minoxidil in promoting hair growth by reducing a hair growth inhibitor.

research Anti-androgen therapy in dermatology: a review

5 citations , December 1979 in “Clinical and Experimental Dermatology”

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

research Pharmacology of Anti-androgens in the Skin

1 citations , January 1989 in “Handbook of experimental pharmacology”

Anti-androgens can help reduce the effects of male hormones on the skin.

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

May 2025 in “Journal of the American Academy of Dermatology”

Oral and topical anti-androgens can help treat female hair loss, but have side effects.

research Clinical applications of antiandrogens

29 citations , October 1988 in “Journal of Steroid Biochemistry”

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

research Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase

5 citations , January 2021 in “Biomedicine & Pharmacotherapy”

Policosanol helps treat hair loss by balancing hormones and supporting hair growth.

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

December 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

Anti-androgens help manage PCOS symptoms like excess hair and acne.

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

December 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

Anti-androgens help manage PCOS symptoms like excess hair and acne.

Substances Declared as Active Ingredients in Topical Anti-Hair Loss Products: A Review of the Evidence for Their Effectiveness in Light of Clinical Studies

research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies

June 2026 in “Homo Politicus (Academy of Humanities and Economics in Lodz)”

The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.

research Percutaneous absorption of a new antiandrogen included in liposomes or in solution

20 citations , December 1995 in “International Journal of Pharmaceutics”

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

research Antiandrogen Therapy for Female-Pattern Hair Loss

January 2005 in “NEJM Journal Watch”

Antiandrogens like spironolactone can help treat female-pattern hair loss.

Hair Follicle Rejuvenation Induced by Topical Minoxidil in a Humanized Mouse Model of Androgenetic Alopecia

research 508 Hair follicle rejuvenation is induced by topical minoxidil administration in a humanized mouse model of androgenetic alopecia

November 2024 in “Journal of Investigative Dermatology”

Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.

research Melatonin and hair physiology: reasons and clinical efficacy data as a topical treatment of androgenic alopecia

March 2014 in “Medicina cutánea ibero-latino-americana”

Melatonin applied to the scalp helps increase hair density in people with early hair loss.

Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments

research Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments

March 2026 in “Preprints.org”

Platelet-rich plasma, microneedling with minoxidil, and topical finasteride are promising treatments for hair loss.

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Related Terms

Products matching "topical anti-androgen"

Research

research Evaluation of RU58841 as an Anti-Androgen in Prostate PC3 Cells and a Topical Anti-Alopecia Agent in the Bald Scalp of Stumptailed Macaques

research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

research Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity

research New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice

research Topical Antiandrogens

research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

research Topical antiandrogens in the treatment of male-pattern baldness

research Topical antiandrogens. What use in dermatology?

research Clascoterone: a new topical antiandrogen agent.

research Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster

research 0951 Breezula, a clinical stage topical anti-androgen, promotes dermal papilla inductivity and reduces IL-6 secretion in balding skin samples ex vivo

research Anti-androgen therapy in dermatology: a review

research Pharmacology of Anti-androgens in the Skin

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

research Clinical applications of antiandrogens

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

research Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies

research Percutaneous absorption of a new antiandrogen included in liposomes or in solution

research Antiandrogen Therapy for Female-Pattern Hair Loss

research 508 Hair follicle rejuvenation is induced by topical minoxidil administration in a humanized mouse model of androgenetic alopecia

research Melatonin and hair physiology: reasons and clinical efficacy data as a topical treatment of androgenic alopecia

research Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments

research Guidelines based management of androgenetic alopecia

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

research Optimal use of topical minoxidil in management of female pattern hair loss in India: an expert opinion