research Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness
New biological pathways and potential treatment targets for male pattern baldness were identified.
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research The mutational analysis of mitochondrial DNA in maternal inheritance of polycystic ovarian syndrome
Mutations in mitochondrial DNA might significantly contribute to the development of Polycystic Ovarian Syndrome.
research The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies
Natural hydrogels can improve wound healing but face challenges in becoming widely used in clinics.
research SnapshotDx Quiz: February 2018
Blocking certain pathways with kinase inhibitors may help treat cutaneous lupus erythematosus.
research Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men’s Health
Loss of the Y chromosome in men is linked to health issues like heart disease and cancer.
research In vivo expression of VCAM1 precedes nephron loss following kidney tubular necrosis
VCAM1 appears early in kidney injury and signals future nephron loss.
research Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses
A new tool accurately identifies human cornea cell states and key factors.
research Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment
Controlling inflammation can help heal diabetic foot ulcers.
research Skin development in the gray short‐tailed opossum (Monodelphis domestica)—From skin respiration to thermoregulation
Gray short-tailed opossums' skin shifts from helping with breathing to regulating body temperature as they grow.
research Exosomes in stroke management: A promising paradigm shift in stroke therapy
Exosome therapy could revolutionize stroke treatment, but more research is needed for human use.
research Molecular mechanisms of asymmetric divisions in mammary stem cells
Disruptions in mammary stem cell division can lead to cancer, but targeting these processes might help treat breast cancer.
research N1-acetylspermidine is a determinant of hair follicle stem cell fate
N1-acetylspermidine promotes hair follicle stem cell self-renewal.
research Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters
Exosomal miRNAs from stem cells can help improve skin health and delay aging.
research Investigating material basis and molecular mechanism of Qing Cuo formula in the treatment of acne based on animal experiments, UPLC-LTQ-Orbitrap-MS and network pharmacology
Qing Cuo Formula may effectively treat acne by reducing inflammation and hormone levels.
research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions
PROTACs offer new ways to treat hard-to-target diseases, with promising drugs for cancer in advanced trials.
research Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations
FOXN1 mutations can cause varying immune and physical issues, with severity influenced by gene activity and possibly other factors.
research Mechanisms of Impaired Skeletal Muscle Regeneration and Therapeutic Approaches in Aging and Chronic Disease
Aging and chronic diseases impair muscle repair, but integrated therapies like exercise and gene editing may help.
research Extracellular vesicles in age-related diseases: disease pathogenesis, intervention, and biomarker
Extracellular vesicles can both worsen and help treat age-related diseases and are useful for early diagnosis.
research Extracellular Vesicles in Alzheimer’s Disease: Dual Roles in Pathogenesis, Promising Avenues for Diagnosis and Therapy
Extracellular vesicles can worsen Alzheimer's but also offer potential for diagnosis and treatment.
research Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management
New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.
research Genome-Wide Identification and Characterization of the Wnt Gene Family in Donkey (Equus asinus): Phylogenetic Analysis and Expression Profiling
This study conducted a comprehensive analysis of the Wnt gene family in donkeys, identifying 19 Wnt genes and highlighting their evolutionary conservation and functional diversification. The research found strong evolutionary conservation among mammals, particularly between donkeys and horses, and identified tissue-specific expression patterns, with Wnt3, Wnt5a, and Wnt4 showing higher expression in the testis, epididymis, and skin, respectively. These findings suggest potential roles in reproductive regulation and tissue homeostasis. The study also revealed that Wnt proteins have typical features of secreted signaling molecules, with variations in their physicochemical properties potentially influencing their stability and interactions. Despite conserved coding sequences, differences in expression patterns suggest regulatory divergence at the transcriptional level. The study emphasizes the need for further experimental validation to confirm the functional roles of Wnt genes in donkeys.
research Exploring Nanotechnology With Traditional Herbal Pharmacology: Nano Carrier-Based Phytochemical Delivery In PCOS Treatment
Combining nanotechnology with herbal medicine may improve PCOS treatment.
research Reviewer #1 (Public review): Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation
Whiskers can form without sensory nerves or Foxd1, thanks to Meis2 in mesenchymal cells.
research Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation
Meis2 is essential for whisker development, independent of nerve involvement.
research Foxn1 in Skin Development, Homeostasis and Wound Healing
Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.
research Advancing Design Strategy of PROTACs for Cancer Therapy
PROTACs show promise for cancer treatment, but designing them effectively is challenging.
research Is There a Histone Code for Cellular Quiescence?
There might be a specific histone code for cellular quiescence, but more research is needed.
research Proteins observed in scalp hair from preschool children
Mothers have more hair proteins than their children, with age-related differences in protein patterns, and some proteins in hair could indicate early childhood development.
research Emerging 3D bioprinting applications in plastic surgery
3D bioprinting in plastic surgery could lead to personalized grafts and fewer complications.
research Extracellular Vesicles for Regenerative Medicine Applications
Extracellular vesicles can help repair and regenerate tissues with less risk of rejection.