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GlossaryWound Fibroblasts

specialized cells that produce collagen to heal injured tissue

Wound fibroblasts are specialized cells that play a crucial role in the healing process of injured tissue. When you get a cut or injury, these cells migrate to the wound site and produce collagen and other extracellular matrix components to help close the wound and form new tissue. They are essential for repairing and strengthening the damaged area.

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Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts

research Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts

35 citations , November 2020 in “Experimental Dermatology”

Different types of skin cells are organized in a special way in large wounds to help with healing and hair growth.

research 974 Single-cell analysis identifies heterogeneity of fibroblasts and myeloid-derived adipocytes in regenerating mouse skin wounds

1 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Fibroblasts and myeloid cells in mouse skin wounds are diverse and can change into different cell types during healing.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

128 citations , August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

research Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration during Wound Healing

5 citations , December 2021 in “Journal of Investigative Dermatology”

Hedgehog signaling in certain cells is crucial for hair growth during wound healing.

Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

research Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

87 citations , January 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

research GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

2 citations , January 2022 in “Experimental Dermatology”

GDNF signaling helps in hair growth and skin healing after a wound.

research Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing

49 citations , January 2018 in “Theranostics”

The new skin patch with human matrix and antibiotic improves wound healing.

research Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing

28 citations , June 2020 in “ACS Biomaterials Science & Engineering”

The new ECM patch greatly improves wound healing and tissue regeneration.

research Wound Healing Effect of Supercritical Carbon Dioxide Datura metel L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

6 citations , July 2023 in “Plants”

Datura metel leaf extracts help heal wounds effectively.

research Structure-guided PEGylated fibroblast growth factor 2 variants accelerate wound healing with improved stability

1 citations , May 2020

Compound 6 is a promising candidate for better wound healing.

research Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing

February 2026 in “Colloids and Surfaces B Biointerfaces”

The composite dressing improved wound healing and hair growth in mice.

Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

research Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

The research found proteins in human skin cells that help with wound healing and hair growth, which could lead to new treatments.

research 768 Dermal fibroblast expression of lef1 is critical to normal skin and hair development and regenerative wound healing in mice

July 2022 in “Journal of Investigative Dermatology”

Lef1 is essential for normal skin, hair growth, and healing wounds in mice.

research Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Lef1 helps adult skin cells maintain their ability to heal wounds and regenerate hair, but the study's methods and conclusions have been questioned.

research 1424 Mapping the establishment of fibroblast heterogeneity during skin development and wound repair

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin heals with scars because only one type of fibroblast is used, not a mix.

research Wound-healing effects of frozen-thawed allogeneic fibroblast sheet transplantation and xenogeneic fibroblast cell sheet transplantation cultured on a new substrate

March 2025 in “Tissue and Cell”

Frozen-thawed fibroblast sheets enhance wound healing and hair growth in mice.

research Effects Of Keratin-Gelatin And Basic Fibroblast Growth Factor-Gelatin Composite Film On Open Wound Healing In Dogs And Cats

January 2007

Keratin-gelatin film improves wound healing in pets better than bFGF-gelatin.

research Effects Of Keratin-Gelatin And Basic Fibroblast Growth Factor-Gelatin Composite Film On Open Wound Healing In Dogs And Cats

January 2007 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)”

Keratin-gelatin film improves wound healing in dogs and cats.

research Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

301 citations , February 2019 in “Nature Communications”

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

research Fibroblasts and wound healing: an update

146 citations , July 2018 in “Regenerative Medicine”

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research Fibroblast state switching orchestrates dermal maturation and wound healing

126 citations , August 2018 in “Molecular Systems Biology”

Fibroblast state switching is crucial for skin healing and development.

research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

28 citations , September 2020 in “International Journal of Molecular Sciences”

Leucocyte-rich platelet-rich plasma boosts cell activity and helps wound healing.

research Rare Gli1+ perivascular fibroblasts promote skin wound repair

2 citations , May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Rare Gli1+ fibroblasts are crucial for skin wound healing.

research Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

16 citations , March 2024 in “International Journal of Molecular Sciences”

Natural compounds and biomimetic engineering can improve wound healing by enhancing fibroblast activity.

research 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration

3 citations , June 2025 in “Wound Repair and Regeneration”

3D bioprinting shows promise for creating skin substitutes, but standardized methods are needed for clinical use.

research Fibroblast state switching orchestrates dermal maturation and wound healing

21 citations , December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)”

Fibroblast behavior is key for skin structure and healing.

research Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study

11 citations , January 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery”

Silymarin improved wound healing and skin regeneration in rats.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations , June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

research Tissue-engineered dermal substitutes constructed by human embryonic stem cell-derived fibroblasts facilitate the repair of skin wounds

March 2026 in “Frontiers in Bioengineering and Biotechnology”

Stem cell-derived fibroblasts can effectively repair skin wounds.