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research Genomic and transcriptomic landscape to decipher the genetic basis of hyperpigmentation in Lanping black-boned sheep (Ovis aries)

7 citations , September 2024 in “BMC Genomics”

This study investigates the genetic basis of hyperpigmentation in Lanping black-boned sheep (LPB) through whole-genome sequencing of 100 LPB and 50 Lanping normal sheep (LPN), alongside 421 datasets from other sheep. The research identifies the evolutionary lineage of LPB from LPN and highlights two genes, ERBB4 and ROR1, as potential contributors to LPB's distinctive pigmentation. Comparative RNA-Seq analysis shows significant upregulation of these genes in LPB tissues, except for ERBB4 in the liver. These findings enhance understanding of melanin synthesis and sheep diversity.

research 0882 Patterning and regional specification of hairy skin

July 2025 in “Journal of Investigative Dermatology”

Secreted inhibitors of Wnt and IGF signaling control hair and tooth development, creating species-specific patterns.

research YAP and TAZ are essential for basal and squamous cell carcinoma initiation

76 citations , June 2018 in “EMBO Reports”

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

research Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment

6 citations , October 2024 in “International Journal of Dermatology”

Proinflammatory fibroblasts and vascular endothelial cells are key in keloid development.

Equine Hoof Stem Progenitor Cells (HPC) CD29+/Nestin+/K15+ – A Novel Dermal/Epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment

research Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment

6 citations , May 2021 in “Stem Cell Reviews and Reports”

Newly found stem cells in horse hooves show promise for treating a hoof disease called laminitis.

Exploring the Mechanism of Platycladi Cacumen in Intervening Androgenetic Alopecia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

research Exploring the mechanism of Platycladi Cacumen in intervening androgenetic alopecia based on network pharmacology, molecular docking, and molecular dynamics simulation

February 2026 in “Scientific Reports”

Platycladi Cacumen may help treat hair loss by affecting certain biological pathways.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

research Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice

133 citations , June 1993 in “Molecular and Cellular Biology”

The human K5 promoter controls specific gene expression in skin cells, with key regulatory elements near the TATA box.

research A propòsit de la possible intervenció de Reinard des Fonoll en la construcció de l'església arxiprestal de Morella

January 1969 in “Santes Creus: Boletín del Archivo Bibliográfico de Santes Creus”

Planarians regenerate using conserved gene expression mechanisms, with runt-1 crucial for cell type specification.

research Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis

19 citations , March 2018 in “Journal of Investigative Dermatology”

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

research Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation

10 citations , August 2023 in “The EMBO Journal”

Kdm6b is crucial for skin cell differentiation.

research The development of several organs and appendages is impaired in mice lacking Sp6

32 citations , February 2008 in “Developmental dynamics”

Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.

research Effects of SLC45A2 and GPNMB on Melanin Deposition Based on Transcriptome Sequencing in Chicken Feather Follicles

10 citations , August 2023 in “Animals”

SLC45A2 and GPNMB genes help control chicken feather color by promoting melanin.

research Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood

33 citations , June 2007 in “Gene Expression Patterns”

CTIP2 may help in skin development and maintenance.

research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

research lncRNAs UC.145 and PRKG1-AS1 Determine the Functional Output of DKK1 in Regulating the Wnt Signaling Pathway in Gastric Cancer

7 citations , May 2022 in “Cancers”

UC.145 may be a new biomarker for predicting gastric cancer.

research The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears

10 citations , November 2008 in “Veterinary Dermatology”

The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.

research FGF20 Secreted From Dermal Papilla Cells Regulate the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine‐Wool Sheep

3 citations , December 2024 in “Journal of Animal Physiology and Animal Nutrition”

FGF20 is essential for hair follicle stem cell growth and development in fine-wool sheep.

research Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research 40 PRLR and PCCA variants associated with hair length in Brangus heifers

November 2020 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

Certain genetic variants in PRLR and PCCA genes may lead to shorter hair in cattle, which could help with heat tolerance.

GBP1 as a Machine Learning-Prioritized Biomarker and Therapeutic Target for Epstein-Barr Virus-Induced Clear Cell Renal Cell Carcinoma: Multi-Omics Causal Validation

research GBP1 as a machine learning-prioritized biomarker and therapeutic target for epstein-barr virus-induced clear cell renal cell carcinoma: multi-omics causal validation

December 2025 in “International Journal of Surgery”

GBP1 is a key target for treating Epstein-Barr virus-related kidney cancer, and finasteride may help.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Comprehensive Program Planning for the Integration of 21st Century Learning Center After-School Programs with Regular Day Programs and Community Partners.

January 1999 in “American Journal of Medical Genetics Part A”

The report expanded knowledge of MBTPS1-related disorders by identifying new symptoms.

research Genetic Association Between Polycystic Ovary Syndrome and the APOA5 rs662799 and PLIN1 rs894160 Metabolic Variants in the Western Saudi Population: A Case-Control Study

January 2024 in “Biomarker Insights”

Certain genetic variants may increase the risk of developing PCOS.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.

White Lupin Cluster Root Acclimation to Phosphorus Deficiency and Root Hair Development Involve Unique Glycerophosphodiester Phosphodiesterases

research White Lupin Cluster Root Acclimation to Phosphorus Deficiency and Root Hair Development Involve Unique Glycerophosphodiester Phosphodiesterases

80 citations , April 2011 in “Plant physiology”

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

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