Search

for
Search:

Sort by

Research

510-540 / 1000+ results

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

Osmanthus fragrans var. aurantiacus Makino may help treat inflammation due to its antioxidative and anti-inflammatory properties.

Analysis of Finasteride Treatment and Its Withdrawal in Rat Hypothalamus and Hippocampus at Whole-Transcriptome Level

research Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level

March 2024 in “Journal of Endocrinological Investigation”

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.

research Medically significant monotypic species Martynia annua L.: A review on ethnobotany, phytochemistry and pharmacology

January 2023 in “Open Access Research Journal of Biology and Pharmacy”

Martynia annua shows promise for future medical research due to its many medicinal properties.

research Development and Characterization of In Situ Gelling Nasal Cilostazol Spanlastics

8 citations , January 2025 in “Gels”

The developed nasal gel improves cilostazol delivery to the brain, enhancing its effectiveness and reducing side effects.

research Attenzione divisa nei pazienti con cerebrolesione acquisita

January 2008 in “Journal of Medicinal Chemistry”

Finasteride may cause sexual and psychological side effects by affecting an enzyme related to epinephrine.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

research Pantolactams as androgen receptor antagonists for the topical suppression of sebum production

5 citations , September 2011 in “Bioorganic & Medicinal Chemistry Letters”

Pfizer found that pantolactam-based compounds can reduce sebum (skin oil) production when applied topically.

research Decision letter for "The Comparative Effects Between Long‐Term and Short‐Term Treatment of Finasteride on Anxiety‐Like and Depression‐Like Behaviors in Early Senescent Male Rats"

September 2024

research Decision letter for "The Comparative Effects Between Long‐Term and Short‐Term Treatment of Finasteride on Anxiety‐Like and Depression‐Like Behaviors in Early Senescent Male Rats"

June 2024

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

research Immunomodulatory Potential of a Bibenzyl-dihydrophenanthrene Derivative Isolated from Calanthe cardioglossa

3 citations , January 2025 in “Journal of Natural Products”

Calancardin B may help reduce inflammation in immune cells.

research 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA_A receptors

44 citations , October 2016 in “Epilepsia”

2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

(1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

research (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production

14 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

research Drug-associated insomnia: A pharmacovigilance study based on FDA adverse event reporting system

April 2026 in “Medicine”

Certain medications, especially nervous system drugs, can cause insomnia, with risks varying by age and gender.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico and in vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

research Preparation and Characterization of Ginger Peel Polysaccharide–Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity

19 citations , November 2022 in “Antioxidants”

Ginger peel polysaccharides modified with zinc effectively reduce inflammation.

research Le financement du cycle de l'eau en région flamande

January 2005 in “Psychoneuroendocrinology”

Finasteride may affect brain chemistry and behavior, offering potential for treating certain mental health conditions.

research ANXA1 affects murine hair follicle growth through EGF signaling pathway

5 citations , December 2020 in “Gene”

ANXA1 influences hair growth in mice through the EGF signaling pathway.

research OA01.03. Antisecretory and antiulcer activities of eclipta alba linn. In rats

1 citations , January 2012 in “Ancient Science of Life”

Eclipta alba extract reduces ulcers and protects the stomach in rats.

research Pharmacological activities of Tridax procumbens (Asteraceae)

5 citations , January 2010 in “Medicinal Plants - International Journal of Phytomedicines and Related Industries”

Tridax procumbens has medicinal properties.

research Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

9 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

research Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha

April 2026 in “microPublication”

Recent research suggests that Minoxidil (MX), a common treatment for androgenetic alopecia (AGA), may act as a partial agonist of Estrogen Receptor α (ERα). This study explored MX's potential estrogenic activity using estrogen-dependent cell lines, tryptophan emission, and computational docking. The findings indicate that MX might not only bind to the Androgen Receptor (AR) as an anti-androgen but also exhibit partial agonist activity on ERα, suggesting a possible connection to sex-hormone pathways in its mechanism for promoting hair growth.

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

research Allopregnanolone (AP) induces opioid inhibition of hypothalamo-pituitary-adrenal (HPA) axis responses to interleukin-1β (IL-1β) in pregnancy

1 citations , October 2005 in “Experimental and Clinical Endocrinology & Diabetes”

Allopregnanolone and opioids together reduce stress hormone responses during pregnancy.

research Changes in expression of the δ subunit of the GABA_Areceptor and in receptor function induced by progesterone exposure and withdrawal

25 citations , July 2006 in “Journal of Neurochemistry”

Progesterone affects GABA_A receptor function by altering δ subunit levels.

research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice

29 citations , October 2009 in “Pharmacology Biochemistry and Behavior”

research The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder

8 citations , April 2021 in “Journal of Clinical Investigation”

Finasteride reduces opioid use and withdrawal symptoms in animals.

research Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

12 citations , June 2001 in “Bioorganic & Medicinal Chemistry”

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

← Previous page Next page →