April 2024 in “Military Medical Research/Military medical research” Cellular and immunotherapies show promise for healing chronic wounds but need more research.
December 2025 in “Journal of Clinical Medicine” Surgical debridement and targeted therapies can effectively heal chronic wounds in KID syndrome.
68 citations
,
March 2019 in “Advanced Healthcare Materials” Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.
3 citations
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January 2025 in “Burns & Trauma” Glucose metabolism is crucial for wound healing but can delay healing in chronic wounds due to increased stress and inflammation.
2 citations
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November 2018 in “Cell Stem Cell” The research found a new way to heal chronic skin ulcers by turning certain cells into skin tissue using specific factors.
Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
1 citations
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December 2025 in “International Journal of Molecular Sciences” Chitosan-based nanocomposites, especially with polyphenols, show promise for treating chronic wounds.
56 citations
,
March 2016 in “International Wound Journal” Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.
July 2024 in “Journal of Investigative Dermatology” Combining certain treatments, including FOL005, may improve healing of difficult wounds.
4 citations
,
August 2024 in “Health Science Reports” Hair follicle punch grafts effectively help heal difficult wounds with few complications.
May 2024 in “British Journal of Community Nursing” PHMB products improve wound healing and quality of life.
165 citations
,
May 2023 in “Science Advances” The hydrogel speeds up healing of infected wounds by providing oxygen and fighting bacteria.
5 citations
,
February 2024 in “Frontiers in bioengineering and biotechnology” Electrospun scaffolds can improve healing in diabetic wounds.
2 citations
,
June 2025 in “International Journal of Nanomedicine” New biomaterials can improve wound healing by promoting nerve and tissue regeneration.
20 citations
,
June 2020 in “Stem Cell Research & Therapy” Using stem cells from fat tissue can significantly improve wound healing in dogs.
8 citations
,
July 2023 in “Inflammation and Regeneration” ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.
2 citations
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April 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The modified Isabgol dressing effectively heals wounds by preventing infections and maintaining moisture.
April 2026 in “Biomedicines” Wound healing is not fully understood, requiring more research and collaboration to improve treatments.
January 2026 in “Materials Today Bio” The hydrogel speeds up diabetic wound healing by reducing inflammation and promoting skin repair.
May 2024 in “European Journal of Immunology” Vitamin B5 and coenzyme A may help regulate the immune system and could improve treatments for chronic diseases and cancer.
56 citations
,
November 2022 in “Biomolecules” Targeting macrophages may improve wound healing.
48 citations
,
January 2018 in “Stem Cells International” Skin-derived stem cells show promise for improving wound healing and creating transplantable tissue.
23 citations
,
February 2025 in “Advanced Materials” The dressing speeds up wound healing by 41% using moisture-generated electricity and antibacterial properties.
November 2025 in “Bioactive Materials” The cryogel effectively heals infected wounds and promotes tissue regeneration without scarring.
December 2024 in “Deleted Journal” New therapies show promise for wound healing, but more research is needed for safe, affordable options.
November 2022 in “IntechOpen eBooks” Nanotechnology can improve wound healing by enhancing treatments and dressings.
May 2022 in “Portuguese Journal of Dermatology and Venereology” Hair-follicle transplants can heal chronic skin ulcers.
238 citations
,
March 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
129 citations
,
July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
65 citations
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May 2017 in “Advances in wound care” Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.