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GlossaryCircular RNAs

circular RNA molecules form closed loops, enhancing stability

Circular RNAs (circRNAs) are a type of RNA molecule that, unlike the more common linear RNAs, form a covalently closed loop. This unique structure makes them more stable and resistant to degradation. They play various roles in gene regulation, including acting as molecular sponges for microRNAs, and are being studied for their potential involvement in diseases and as therapeutic targets.

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The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations , February 2022 in “Frontiers in cell and developmental biology”

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)

39 citations , January 2020 in “Scientific Reports”

Four circRNAs were found to be significantly different in cashmere goat skin, affecting cashmere fineness.

research The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

11 citations , October 2021 in “Frontiers in Cell and Developmental Biology”

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles

research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles

7 citations , June 2022 in “Czech Journal of Animal Science”

Certain circular RNAs help cashmere goats grow more hair.

Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

research Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

The research found key RNA networks that may control hair growth in cashmere goats.

research Screening of circRNAs Associated with Secondary Wool Follicle Development in Fine-Wool Sheep and Construction of Their ceRNA Network

September 2025 in “Animals”

Key circRNAs play a role in wool follicle development, aiding in breeding better quality wool sheep.

research Identification and characterization of circRNAs in the skin during the wool follicle development of Aohan fine wool sheep

October 2019 in “Research Square (Research Square)”

Certain circular RNAs may regulate wool follicle growth in sheep.

research The Role of MicroRNA, Long Non-Coding RNA and Circular RNA in the Pathogenesis of Polycystic Ovary Syndrome: A Literature Review

1 citations , January 2024 in “International journal of molecular sciences”

MicroRNAs could be key biomarkers and therapeutic targets for PCOS.

research Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex

48 citations , May 2019 in “Genome Biology”

Researchers found that certain RNA circles in the brain are linked to disease risk, but their exact role in disease is still unknown.

research Identification of functional circRNAs regulating ovarian follicle development in goats

8 citations , September 2024 in “BMC Genomics”

circCFAP20DC helps goat ovarian cells grow, aiding follicle development.

research The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis

19 citations , March 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research A symphony of signals: the intricate role of lncRNAs in dermatological disorders

1 citations , November 2025 in “Clinical and Experimental Medicine”

lncRNAs are important for understanding and treating skin diseases.

research Molecular Mechanisms Affecting Development of Animal Fibers and Some Studies on Goats

June 2023 in “Livestock studies”

The article concludes that understanding the molecular processes in hair follicle development can improve the quality of fibers like Angora and cashmere.

Whole-Transcriptome Analysis Reveals the Profiles and Roles of Coding and Non-Coding RNAs During Hair Follicle Cycling in Rex Rabbits

research Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits

January 2025 in “BMC Genomics”

Key genes and RNA networks regulate hair growth and follicle density in Rex rabbits.

research Regulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats

7 citations , October 2023 in “BMC Genomics”

Noncoding RNAs help determine cashmere quality in goats.

CircRNA-0100 Positively Regulates the Differentiation of Cashmere Goat SHF-SCs into Hair Follicle Lineage via Sequestering miR-153-3p to Heighten the KLF5 Expression

research CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression

9 citations , February 2022 in “Archives animal breeding/Archiv für Tierzucht”

A circular RNA helps cashmere goat hair cells become hair follicles by blocking a molecule to boost a gene important for hair growth.

research Whole transcriptome sequencing of different hair types in inner Mongolian cashmere goats

April 2026 in “BMC Genomics”

Hair type differences in cashmere goats are linked to keratin and cytoskeletal organization.

research Comprehensive Transcriptome Analysis of Hair Follicle Morphogenesis Reveals That lncRNA-H19 Promotes Dermal Papilla Cell Proliferation through the Chi-miR-214-3p/β-Catenin Axis in Cashmere Goats

7 citations , September 2022 in “International journal of molecular sciences”

The research found that the molecule lncRNA-H19 helps hair follicle cells grow by affecting certain cell pathways in cashmere goats.

research Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep

112 citations , September 2021 in “BMC Biology”

Key genes and factors crucial for hair follicle development and wool traits in Merino sheep were identified.

research Recent advances in exosomal non‐coding RNA‐based therapeutic approaches for photoaging

3 citations , September 2023 in “Skin research and technology”

New treatments for skin damage from UV light using stem cells and their secretions show promise for skin repair without major risks.

Hierarchically Assembled Nanofiber Scaffolds With Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment

research Hierarchically Assembled Nanofiber Scaffolds with Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment

February 2024 in “Advanced Science”

The new scaffold with two growth factors speeds up skin healing and reduces scarring.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research The role of WNT10B in physiology and disease: A 10-year update

27 citations , February 2023 in “Frontiers in Cell and Developmental Biology”

WNT10B is important for body functions and linked to diseases like osteoporosis, obesity, and cancer.

research Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep

January 2025 in “BMC Genomics”

Long non-coding RNAs help regulate wool fineness in Gansu alpine fine-wool sheep.

research CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner

January 2024 in “Animals”

Circular RNA ERCC6 helps activate stem cells important for cashmere goat hair growth by interacting with specific molecules in an m6A modification-dependent way.

research Long and short non-coding RNA and radiation response: a review

41 citations , February 2021 in “Translational research”

Non-coding RNAs could help detect and treat radiation damage.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2

research Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

100 citations , November 2021 in “Cell Research”

Cepharanthine and Trifluoperazine are effective against SARS-CoV-2.

N6-Methyladenosine Modification of circRNA-ZNF638 Contributes to the Induced Activation of SHF Stem Cells Through miR-361-5p/Wnt5a Axis in Cashmere Goats

research N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats

2 citations , November 2022 in “Animal Bioscience”

A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.