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GlossaryCollagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Lack of Collagen VI Promotes Wound-Induced Hair Growth

32 citations , May 2015 in “Journal of Investigative Dermatology”

Mice without collagen VI have slower hair growth normally but faster regrowth after injury.

research Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

July 2025 in “Advanced Science”

Collagen VI and Semaphorin 3C are important for hair pigmentation and could help treat pigmentation disorders.

research Alopecia in Patients with Collagen VI-Related Myopathies: A Novel/Unrecognized Scalp Phenotype

April 2023 in “International journal of molecular sciences”

People with Collagen VI-related myopathies may often have hair loss and scalp issues.

research Role of collagen VI in peripheral nerves and wound-induced hair regrowth

January 2015

Collagen VI is crucial for nerve function and affects wound-induced hair regrowth.

research
Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study

34 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.

research In Vivo Non-Invasive Observation of Dynamic Changes in Hair Shaft, Melanin, and Collagen During the C57BL/6 Follicle Cycle

September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Non-invasive methods can effectively monitor hair growth cycles, aiding hair loss treatment development.

Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles

research ESDR573 - Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Generate Diverse Effects on Stem Cells and Progeny in Human Scalp Hair Follicles Ex Vivo

September 2022

Collagen peptides may help maintain hair growth and could be beneficial for hair loss conditions.

research Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women—A Randomized Controlled Study

September 2025 in “Clinics and Practice”

Collagen with calcium and vitamin D improves bone health, skin elasticity, and reduces hair loss in menopausal women.

research The three-dimensional microvascular and collagen fibrillar arrangements around rat vibrissa hairs as revealed by scanning electron microscopy

3 citations , October 1994 in “Medical Molecular Morphology”

The lower part of rat vibrissa hair gets more blood and is well-protected for growth.

research Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells

1 citations , May 2024 in “Journal of Dermatological Science”

Injecting specific cells into the skin can help improve skin structure and reduce blisters in a genetic skin disorder.

Targeted Nutritional Supplementation for Telogen Effluvium: Multicenter Study on Efficacy of a Hydrolyzed Collagen, Vitamin, and Mineral-Based Induction and Maintenance Treatment

research Targeted nutritional supplementation for telogen effluvium: Multicenter study on efficacy of a hydrolyzed collagen, vitamin., and mineral-based induction and maintenance treatment

3 citations , March 2022 in “International Journal of Trichology”

Special supplements with collagen, vitamins, and minerals can help treat hair loss.

research Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium

May 2025 in “International Journal of Trichology”

The supplement improved hair health and reduced shedding in people with telogen effluvium.

research From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization

May 2026 in “Frontiers in Cell and Developmental Biology”

Collagen networks play a key role in hair loss and follicle miniaturization.

research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research 573 Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Generate Diverse Effects on Stem Cells and Progeny in Human Scalp Hair Follicles Ex Vivo

November 2022 in “Journal of Investigative Dermatology”

Fish-derived collagen may help hair grow longer and affect hair stem cells, while bovine collagen could benefit hair stem cell maintenance, potentially aiding in hair loss conditions.