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GlossaryCollagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Lack of Collagen VI Promotes Wound-Induced Hair Growth

32 citations , May 2015 in “Journal of Investigative Dermatology”

Mice without collagen VI have slower hair growth normally but faster regrowth after injury.

research Alopecia in Patients with Collagen VI-Related Myopathies: A Novel/Unrecognized Scalp Phenotype

April 2023 in “International journal of molecular sciences”

People with Collagen VI-related myopathies may often have hair loss and scalp issues.

research Role of collagen VI in peripheral nerves and wound-induced hair regrowth

January 2015

Collagen VI is crucial for nerve function and affects wound-induced hair regrowth.

research <p>Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study</p>

34 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.

research In Vivo Non-Invasive Observation of Dynamic Changes in Hair Shaft, Melanin, and Collagen During the C57BL/6 Follicle Cycle

September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Non-invasive methods can effectively monitor hair growth cycles, aiding hair loss treatment development.

Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles

research ESDR573 - Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Generate Diverse Effects on Stem Cells and Progeny in Human Scalp Hair Follicles Ex Vivo

September 2022

Collagen peptides may help maintain hair growth and could be beneficial for hair loss conditions.

research Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women—A Randomized Controlled Study

September 2025 in “Clinics and Practice”

Collagen with calcium and vitamin D improves bone health, skin elasticity, and reduces hair loss in menopausal women.

research The three-dimensional microvascular and collagen fibrillar arrangements around rat vibrissa hairs as revealed by scanning electron microscopy

3 citations , October 1994 in “Medical Molecular Morphology”

The lower part of rat vibrissa hair gets more blood and is well-protected for growth.

Targeted Nutritional Supplementation for Telogen Effluvium: Multicenter Study on Efficacy of a Hydrolyzed Collagen, Vitamin, and Mineral-Based Induction and Maintenance Treatment

research Targeted nutritional supplementation for telogen effluvium: Multicenter study on efficacy of a hydrolyzed collagen, vitamin., and mineral-based induction and maintenance treatment

3 citations , March 2022 in “International Journal of Trichology”

Special supplements with collagen, vitamins, and minerals can help treat hair loss.

research Effect of a Hydrolyzed Collagen, Vitamin, and Zinc Containing Nutritional Supplement on Telogen Effluvium

May 2025 in “International Journal of Trichology”

The supplement improved hair health and reduced shedding in people with telogen effluvium.

research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research 573 Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Generate Diverse Effects on Stem Cells and Progeny in Human Scalp Hair Follicles Ex Vivo

November 2022 in “Journal of Investigative Dermatology”

Fish-derived collagen may help hair grow longer and affect hair stem cells, while bovine collagen could benefit hair stem cell maintenance, potentially aiding in hair loss conditions.

Management of Chemotherapy-Induced Alopecia Using a Topical Botanical Lotion via a Proposed Triple-Action on Apoptosis, Inflammation, and Collagen

research Abstract 3478: Management of chemotherapy induced alopecia using a topical botanical lotion via a proposed triple-action on apoptosis, inflammation and collagen

July 2016 in “Cancer Research”

A topical lotion helped manage hair loss from chemotherapy by affecting cell death, inflammation, and collagen, with no side effects.

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

Tideglusib may help bone regeneration without being toxic at low doses.

research Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy

48 citations , March 2020 in “Stem Cell Research & Therapy”

Using a collagen sponge scaffold helps stem cells become more like skin cells.

research Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo

3 citations , January 2022 in “Burns & Trauma”

CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.

research Effect of Minoxidil Sulfate on the Growth of Human Anagen Hair Follicles Grown in Collagen Gels, and on the Colony Growth of Human Cultured Outer Root Sheath Cells in vitro.

1 citations , January 1992 in “The Nishinihon Journal of Dermatology”

Minoxidil sulfate did not enhance hair growth or cell proliferation at tested levels.

An Umbilical Cord Blood-Derived Exosome Product Stimulates Hair Growth Through Laminin V and Collagen XVII: An Ex Vivo Study

research A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study

November 2025 in “Archives of Dermatological Research”

Limelight (CB-EVs) safely promotes hair growth.

research [Skin-like structure generated from implantation of hair follicle bulb cells into collagen/chitosan porous scaffolds in vitro].

July 2004 in “PubMed”

Hair bulb cells can create skin-like tissues for potential skin repair.

research Demonstration of early anagen-specific stimulatory factors within skin tissue for in vitro mesenchymal-epithelial interaction in collagen embedded hair follicle mixed culture

August 1993 in “Journal of Dermatological Science”

In Vitro Biomimetic Platforms Featuring a Perfusion System and 3D Spheroid Culture Promote the Construction of Tissue-Engineered Corneal Endothelial Layers

research In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers

14 citations , April 2017 in “Scientific Reports”

Using a perfusion system and 3D spheroid culture improves the growth of corneal cell layers for tissue engineering.

CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization

research O19 CYLD cutaneous syndrome tumours demonstrate increased NF-κB signalling and diminished collagen organisation.

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.

research In vitro skin models to study epithelial regeneration from the hair follicle

19 citations , March 2017 in “PLoS ONE”

PSU are better than THF at regenerating skin layers in lab models.

research Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds

6 citations , January 2024 in “Frontiers in Bioengineering and Biotechnology”

The new wound dressing speeds up healing of infected wounds safely and effectively.

research Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration

December 2025 in “Frontiers in Nutrition”

Collagen supplements may improve skin, joints, and recovery, especially with added nutrients.

research Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing

28 citations , June 2020 in “ACS Biomaterials Science & Engineering”

The new ECM patch greatly improves wound healing and tissue regeneration.