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GlossaryDermal Papilla Cells

specialized cells at hair follicle base crucial for hair growth

Dermal Papilla Cells (DPCs) are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by interacting with surrounding cells to regulate the hair growth cycle. These cells are essential for the formation of new hair follicles and are a key focus in research on hair loss treatments and regenerative medicine.

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research Defining ovine dermal papilla cell markers and identifying key signaling pathways regulating its intrinsic properties

5 citations , February 2023 in “Frontiers in Veterinary Science”

Ovine dermal papilla cells are promising for hair growth research due to their stable properties and hair-inducing abilities.

research Effects of Natural Herbal Marker Compounds on Human Dermal Papilla Cell Growth Regulation

December 2023

Four natural compounds were found to promote hair growth effectively.

research Teicoplanin alleviates androgenetic alopecia through inhibition of androgen receptor expression and enhancing dermal papilla cell proliferation

February 2026 in “European Journal of Pharmacology”

Teicoplanin may help treat hair loss by reducing androgen receptors and boosting hair cell growth.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

research 1361 A novel cell surface marker for hair follicle dermal cells throughout hair morphogenesis and cycling

April 2018 in “Journal of Investigative Dermatology”

Researchers found that the Leptin receptor is a consistent marker for hair follicle dermal cells, which may help future hair research.

research Heat-Killed Enterococcus faecalis EF-2001 Induces Human Dermal Papilla Cell Proliferation and Hair Regrowth in C57BL/6 Mice

4 citations , May 2022 in “International journal of molecular sciences”

Heat-killed Enterococcus faecalis EF-2001 may promote hair growth and transition hair follicles to the growth phase.

Gene Expression Analysis of Chondrogenic Markers in Hair Follicle Dermal Papilla Cells Under the Effect of Laser Photobiomodulation and Synovial Fluid

research Gene Expression Analysis of Chondrogenic Markers in Hair Follicle Dermal Papillae Cells Under the Effect of Laser Photobiomodulation and the Synovial Fluid

2 citations , July 2019 in “Journal of lasers in medical sciences”

Laser treatment and synovial fluid can change hair follicle cells to resemble joint cells, with the changes being more significant when both treatments are used together.

research Hair growth-promoting effect of human dermal stem/progenitor cell-derived conditioned medium

9 citations , August 2015 in “Tissue Engineering and Regenerative Medicine”

Human skin cell byproducts can potentially be used to treat hair loss and promote hair growth.

research Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss

2 citations , June 2022 in “International Journal of Molecular Sciences”

Lower levels of certain genes in hair cells improve hair loss treatment outcomes.

research Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments

28 citations , March 2010 in “Histochemistry and Cell Biology”

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

research Hair follicle stem cell marker nestin expression in regenerating hair follicles of patients with alopecia areata

6 citations , March 2011 in “European Journal of Dermatology”

Nestin-positive cells are important for hair follicle regeneration in alopecia areata.

research Reprogramming of Aged Dermal Papilla Cells in Vitro: In Silico Insight into the Biomarkers of Hair Growth and Tissue Repair

December 2025 in “Preprints.org”

Aging dermal papilla cells can be reprogrammed for potential hair growth and skin repair.

research Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway

36 citations , April 2016 in “Biochimie”

A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.

research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

New cells are added to the hair's dermal papilla during the active growth phase.

research Impact of substrate stiffness on dermal papilla aggregates in microgels

12 citations , January 2018 in “Biomaterials Science”

Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.

research Decision letter: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

April 2018

Fgf20 is crucial for hair follicle formation by influencing cell movement and growth.

research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Use of human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells for the generation of hair inductive dermal cells

September 2016 in “Journal of dermatological science”

Human induced pluripotent stem cells can be used to create cells that help grow hair.

research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Vitamin B3 may help prevent hair loss and promote hair growth by protecting scalp cells from stress and reducing hair growth-blocking proteins.

research Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice

21 citations , May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

research CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth

15 citations , July 2016 in “Biochemical Journal”

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

research The in vitro plasticity of hair follicle dermal and mesenchymal stem cells

January 2008 in “Durham e-Theses (Durham University)”

Hair follicle stem cells are similar to mesenchymal stem cells and can become neural-like cells under certain conditions.

research Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel

4 citations , July 2022 in “Annals of translational medicine”

Scientists created complete hair-like structures by growing mouse skin cells together in a special gel.

Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles

research Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

6 citations , July 2022 in “World journal of stem cells”

Using extracellular vesicles from stem cells can help hair grow by affecting scalp cells and hair follicles.

Single-Cell RNA Sequencing of Different Fibroblast Populations Cultured from Female Scalp Reveals Significant Alterations to Transcriptional Profiles with Age

research 1424 Single-cell RNA sequencing of different fibroblast populations cultured from female scalp reveals significant alterations to transciptional profiles with age

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Aging changes female scalp cells, likely affecting hair health.

research Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells

151 citations , February 2006 in “Stem Cells and Development”

Hair follicles can be a good source of stem cells like those from bone marrow.

research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene

January 2024 in “Animals”

SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.

research 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium

August 2009 in “Mechanisms of Development”

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

research Electric Stimulation at 448 kHz Modulates Proliferation and Differentiation of Follicle Dermal Papilla Cells

October 2024 in “Cosmetics”

Electric stimulation at 448 kHz can promote hair growth by enhancing cell activity in hair follicles.

research Human Induced Pluripotent Stem Cell–Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

64 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human stem cells can help form hair follicles in mice.