research Direct Vasodilators and Sympatholytic Agents
Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.
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330-360 / 1000+ resultsresearch LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent
Dutasteride may help reduce brain inflammation and improve cognition.
research Modern approaches to diagnostics of hyperandrogenism distributed forms in reproductive aged women
Accurate diagnosis of hyperandrogenism, especially PCOS, is crucial for managing fertility and metabolic risks in women.
research Changes in Prolactin and Insulin Resistance in PCOS Patients Undergoing Metformin Treatment: A Retrospective Study
Lower baseline prolactin levels may lead to better insulin resistance improvement with metformin in PCOS patients.
research ENZYMES
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges
Biodegradable polymers can improve cannabinoid delivery but need more clinical trials.
research Hair cortisol in drug-naïve first-episode individuals with psychosis
First-episode psychosis patients have higher hair cortisol levels, indicating early stress response issues.
research Drug-associated insomnia: A pharmacovigilance study based on FDA adverse event reporting system
Certain medications, especially nervous system drugs, can cause insomnia, with risks varying by age and gender.
research Management of Sexual Dysfunction in Postmenopausal Breast Cancer Patients Taking Adjuvant Aromatase Inhibitor Therapy
Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.
research American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Hyperandrogenic Disorders
The guidelines help doctors diagnose and treat hormone-related disorders in women.
research Prefrontal 5α-reductase 2 mediates male-specific acute stress response
5α-reductase 2 is crucial for stress response in male rats.
research Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology
Prolactin affects skin health and may lead to new treatments for skin and hair issues.
research A Review of the Characteristics of Clinical Trials and Potential Medications for Alcohol Dependence: Data Analysis from ClinicalTrials.gov
No medications for alcohol dependence have been approved for marketing yet.
research Characterisation of Four New Genes in the Ovine KAP19 Family
Four new genes related to sheep wool were discovered, showing genetic diversity.
research Impaired Prolactin-Lowering Effects of Metformin in Women with Polycystic Ovary Syndrome
Metformin lowers prolactin in women without PCOS but not in those with PCOS, where it reduces other hormones instead.
research Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies
Caffeine can boost health, prevent diseases, and improve performance, with new methods enhancing its benefits.
research The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.
research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
research Cell fate decisions: emerging roles for metabolic signals and cell morphology
Metabolic signals and cell shape influence how cells develop and change.
research Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance
The new nanoparticles could improve melanoma treatment by working better than current options.
research Neuroendocrine Determinants of Polycystic Ovary Syndrome
Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.
research The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development
Blocking the KATP channel may help treat migraines.
research Proopiomelanocortin (POMC) and Psychodermatology
Psychological stress can worsen skin conditions like psoriasis and acne.
research Drug-induced hair pigmentation: Clinical perspectives and updates
Certain drugs can change hair color, either lightening or darkening it.
research Bioinspired Polymers: Transformative Applications in Biomedicine and Regenerative Medicine
Bioinspired polymers are promising for advanced medical treatments and tissue repair.
research Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice
A mild botulinum toxin injection improved sperm production and movement in aging mice.
research Food and medicine homology: a potential nutritional intervention strategy for post-acute COVID-19 syndrome
FMH foods may help manage post-acute COVID-19 symptoms safely and easily.
research Industry Updates from the Field of Stem Cell Research and Regenerative Medicine in December 2019
Significant progress and collaborations in stem cell research and regenerative medicine were made, including advancements in hair growth, cancer therapies, and treatments for neurological disorders.
research Hirsutism-A Comprehensive Update of Embryology, Aetiopathogenesis and Therapeutic Approach
The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.
research Recent Progress and Morphological Distribution of Polydopamine-Based Biomaterials and Their Applications
Polydopamine is promising for personalized medicine and biomedical technology due to its strong adhesion and biocompatibility.