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Did you mean Double-stranded RNA?

GlossaryDouble-stranded RNA

molecule with two complementary RNA strands bound together

Double-stranded RNA (dsRNA) is a molecule consisting of two complementary strands of RNA that are bound together, similar to the structure of DNA. In biological systems, dsRNA is often a signal of viral infection, triggering immune responses in cells. It is also used in research and therapeutic applications, such as RNA interference (RNAi), to silence specific genes.

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H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

research 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research Abstract 152

April 2015 in “Plastic and Reconstructive Surgery”

TLR3 activation helps improve skin and hair follicle healing in mice.

research Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding

28 citations , October 2019 in “Seminars in Cell & Developmental Biology”

Hair can regrow in large wounds through a process similar to how hair forms in embryos, and understanding this could lead to new treatments for hair loss or scarring.

research Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration

5 citations , March 2019 in “Experimental dermatology”

Activating TLR3 may help produce retinoic acid, important for tissue regeneration.

research A Perspective on RNAi-Based Biopesticides

140 citations , February 2020 in “Frontiers in Plant Science”

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Genomewide differential expression profiling of long non-coding RNAs in androgenetic alopecia in a Chinese male population

11 citations , April 2017 in “Journal of The European Academy of Dermatology and Venereology”

Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

New treatments targeting specific genes show promise for treating keratin disorders.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research A symphony of signals: the intricate role of lncRNAs in dermatological disorders

1 citations , November 2025 in “Clinical and Experimental Medicine”

lncRNAs are important for understanding and treating skin diseases.

research The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology

22 citations , April 2017 in “Journal of Investigative Dermatology”

Non-coding RNAs are crucial for skin development and health.

research Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus)

129 citations , October 2017 in “BMC Genomics”

The study improved understanding of gene roles in cashmere goat hair growth, aiding future cashmere production.

research Small RNAs Loom Large During Reprogramming

18 citations , June 2011 in “Cell stem cell”

MicroRNAs can reprogram cells into stem cells faster and more efficiently than traditional methods.

Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product Demonstrating Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

research Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

March 2026 in “Preprints.org”

The combined stem cell secretome in the skin care product effectively reduces inflammation and promotes tissue regeneration.

research The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

11 citations , October 2021 in “Frontiers in Cell and Developmental Biology”

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

research Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa

33 citations , April 2020 in “Journal of Clinical Investigation”

Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.

Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

research Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

The research found key RNA networks that may control hair growth in cashmere goats.

research Comprehensive Transcriptome Analysis of Hair Follicle Morphogenesis Reveals That lncRNA-H19 Promotes Dermal Papilla Cell Proliferation through the Chi-miR-214-3p/β-Catenin Axis in Cashmere Goats

7 citations , September 2022 in “International journal of molecular sciences”

The research found that the molecule lncRNA-H19 helps hair follicle cells grow by affecting certain cell pathways in cashmere goats.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research Screening of circRNAs Associated with Secondary Wool Follicle Development in Fine-Wool Sheep and Construction of Their ceRNA Network

September 2025 in “Animals”

Key circRNAs play a role in wool follicle development, aiding in breeding better quality wool sheep.

MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration

research MicroRNAs in the skin: role in development, homoeostasis and regeneration

31 citations , July 2017 in “Clinical Science”

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

research Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods

16 citations , December 2016 in “Molecular Medicine Reports”

Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.

research Long and short non-coding RNA and radiation response: a review

41 citations , February 2021 in “Translational research”

Non-coding RNAs could help detect and treat radiation damage.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

research Catalytic Antibodies in Norm and Systemic Lupus Erythematosus

25 citations , May 2017 in “InTech eBooks”

Catalytic antibodies are early indicators and active participants in the development of systemic lupus erythematosus.

research Transposon control as a checkpoint for tissue regeneration

14 citations , November 2022 in “Development”

Controlling transposable elements is crucial for successful tissue regeneration.

research Spatiotemporal control of CRISPR/Cas9 gene editing

51 citations , June 2021 in “Signal Transduction and Targeted Therapy”

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

research Pre-clinical non-viral vectors exploited forin vivoCRISPR/Cas9 gene editing: an overview

23 citations , January 2022 in “Biomaterials Science”

Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.