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GlossaryEpidermal Repair

process of skin healing and regenerating after damage

Epidermal repair refers to the process by which the outermost layer of the skin, the epidermis, heals after being damaged. This involves the regeneration of skin cells, the reformation of the skin barrier, and the restoration of its protective functions. For professionals, it includes cellular activities like keratinocyte migration, proliferation, and differentiation, as well as the re-establishment of the skin's structural integrity and function.

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Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair

46 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

The vitamin D receptor is essential for skin stem cells to grow, move, and become different cell types needed for skin healing.

research The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling

35 citations , July 2022 in “Frontiers in Cell and Developmental Biology”

Proper mTOR signaling is crucial for healthy skin and preventing skin diseases.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.

research Necl2 regulates epidermal adhesion and wound repair

35 citations , September 2009 in “Development”

Necl2 affects skin cell behavior and slows wound healing.

research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair

10 citations , July 2019 in “Advances in Wound Care”

Reducing Flightless I protein improves wound healing by activating skin stem cells.

research Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes

March 2026 in “The Journal of Steroid Biochemistry and Molecular Biology”

Deleting vitamin D and calcium receptors in skin cells increases skin cancer risk by reducing DNA repair and stress response.

research Tissue repair and stress responses of aged skin epidermis

January 2020

Aging disrupts skin repair and stress responses, but exercise-related IL-15 improves wound healing and skin health in older skin.

research Role of Vitamin D and Calcium in Epidermal Wound Repair

1 citations , December 2017 in “Wound healing”

Vitamin D and calcium are crucial for proper skin wound healing.

research [Research progress of Wnt signaling pathway in the epidermal repair].

June 2012 in “PubMed”

The Wnt signaling pathway is essential for skin repair and healing.

research Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair

28 citations , December 2008 in “Laboratory investigation”

Activin activation in skin cells speeds up wound healing without affecting scar quality.

research Role of epidermal stem cells in repair of partial-thickness burn injury after using Moist Exposed Burn Ointment (MEBO®) histological and immunohistochemical study

20 citations , January 2014 in “Tissue and Cell”

MEBO ointment helps activate and grow skin stem cells for burn healing.

research Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

86 citations , April 2016 in “Nature Communications”

Notch1 helps skin heal by attracting specific immune cells.

research Epidermal Notch1 recruits innate lymphoid cells to orchestrate normal skin repair

January 2014 in “Durham e-Theses (Durham University)”

Notch1 helps skin heal by attracting cells that aid repair.

Application of Second Near Infrared Fluorescence Imaging to Trace CelTrac1000-Labeled Hair Follicle Epidermal Neural Crest Stem Cells in Repairing Rat Facial Nerve Defects

research Application of second near infrared fluorescence imaging to trace CelTrac1000-labeled hair follicle epidermal neural crest stem cells in repairing rat facial nerve defects

November 2023 in “Research Square (Research Square)”

NIR-II imaging effectively tracked stem cells that helped repair facial nerve defects in rats.

research Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

1279 citations , November 2005 in “Nature Medicine”

research Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

100 citations , August 2008 in “American Journal Of Pathology”

VEGF-A is crucial for normal skin function and may be linked to psoriasis.

research Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

52 citations , April 2013 in “Developmental Cell”

Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research IL-1 Receptor–Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation

20 citations , July 2017 in “Journal of Investigative Dermatology”

IL-1 receptor absence in mice leads to skin cysts and changes in immune response after UVB exposure.

research Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

7 citations , August 2022 in “Nature communications”

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

research Scaffolds for epidermal tissue engineering

1 citations , January 2019 in “Elsevier eBooks”

New scaffold materials help heal severe skin wounds and improve skin regeneration.

research Epidermal homeostasis: a balancing act of stem cells in the skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

143 citations , May 2017 in “Nature cell biology”

Wounded skin cells can revert to stem cells and help heal.

research Transcriptional Control of Epidermal Stem Cells

4 citations , January 2013 in “Advances in Experimental Medicine and Biology”

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

research Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

28 citations , February 2014 in “PLoS ONE”

Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.

research Wound repair at a glance

733 citations , September 2009 in “Journal of Cell Science”

Wound healing is a complex, multi-phase process involving various cells and activities to repair skin damage.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

354 citations , February 2011 in “Genes & Development”

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

research Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

221 citations , July 2012 in “Proceedings of the National Academy of Sciences of the United States of America”

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

research Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration

162 citations , July 2011 in “Biomacromolecules”

Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.