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GlossaryEpidermal Thickness

measurement of skin's outermost layer's depth

Epidermal thickness refers to the measurement of the outermost layer of the skin, known as the epidermis. This thickness can vary depending on the body part and individual factors, influencing skin's protective barrier and its ability to retain moisture. For professionals, understanding epidermal thickness is crucial for diagnosing skin conditions, planning treatments, and assessing the skin's overall health.

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research Estrogen Receptor α, but not Estrogen Receptor β, is Involved in the Regulation of the Hair Follicle Cycling as well as the Thickness of Epidermis in Male Mice

72 citations , November 2002 in “Journal of Investigative Dermatology”

Estrogen receptor α controls hair growth cycles and skin thickness in male mice.

research Secretome-Based Therapy Promotes Epidermal Thickness Recovery and Follicular Regrowth in Fluconazole-Induced Alopecia in Rats

October 2025 in “International Journal of Cell and Biomedical Science”

hUC-MSC secretome can help regrow hair in cases of hair loss.

A Matrix-Derived Bioactive Peptide Enhances Epidermal Thickness and Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites

research A Matrix‐Derived Bioactive Peptide Enhances Epidermal Thickness and Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites

May 2025 in “Wound Repair and Regeneration”

TSN6 peptide improves skin thickness and hair growth.

research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation

July 2024 in “Journal of Investigative Dermatology”

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

research Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound

1 citations , January 2019 in “The International Journal of Lower Extremity Wounds”

Artificial dermal template treatment can stimulate complete skin and hair follicle regrowth.

Wnt4 Increases the Thickness of the Epidermis in Burn Wounds by Activating Canonical Wnt Signalling and Decreasing Cell Junctions Between Epidermal Cells

research Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells

1 citations , January 2023 in “Burns & Trauma”

Wnt4 protein makes the outer skin layer thicker in burn wounds by turning on a specific healing pathway and loosening the connections between skin cells.

research Role of epidermal stem cells in repair of partial-thickness burn injury after using Moist Exposed Burn Ointment (MEBO®) histological and immunohistochemical study

20 citations , January 2014 in “Tissue and Cell”

MEBO ointment helps activate and grow skin stem cells for burn healing.

research Differention of ES cell-derived epidermal stem cells in full thickness skin defects

January 2007 in “Jiepouxue yanjiu”

ES cell-derived stem cells can help regenerate skin and form gland-like structures.

Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

research Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

28 citations , February 2014 in “PLoS ONE”

Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.

Study of the Impact of SKPs' Secreted Factors and a Botanical Extract Derived from Jasmine on Keratinocyte Growth and Reconstructed Human Epidermis Thickness

research 692 Study of the impact of SKPs’ secreted factors and of a botanical extract derived from jasmine on keratinocytes growth and reconstructed human epidermis thickness

April 2016 in “Journal of Investigative Dermatology”

Jasmine extract helps skin cell growth and makes artificial skin thicker, especially when used with skin-derived precursors.

research Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis

65 citations , August 2013 in “Acta Biomaterialia”

The new matrix improves skin regeneration and graft performance.

research Effect of keratin‐gelatin and bFGF‐gelatin composite film as a sandwich layer for full‐thickness skin mesh graft in experimental dogs

50 citations , December 2007 in “Journal of Biomedical Materials Research Part B Applied Biomaterials”

Keratin-gelatin films improve skin graft success in dogs.

research Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy

31 citations , September 2016 in “PLoS ONE”

Cell division orientation varies by body site and is linked to epidermal thickness and cell density.

research Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin

10 citations , November 2015 in “Experimental Dermatology”

Skin RAGE levels are linked to inflammation and cell death.

research Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype

10 citations , September 1997 in “Molecular carcinogenesis”

Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.

research Caracterização clínica e laboratorial do acometimento dos folículos velos e da epiderme da face, pescoço e região anterossuperior do tórax na alopecia frontal fibrosante

2 citations , December 2018

Alopecia frontal fibrosante affects facial vellus hair and can be diagnosed with dermatoscopy.

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

Aging reduces stem cell activation, leading to hair loss in mice lacking a specific enzyme.

research Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23

January 2023 in “Journal of cosmetic dermatology”

The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.

research Reconstitution of full-thickness skin by microcolumn grafting

38 citations , June 2016 in “Journal of Tissue Engineering and Regenerative Medicine”

Microcolumn grafting can effectively regenerate full-thickness, functional skin without scarring.

research Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane

23 citations , May 2019 in “Stem cell research & therapy”

iPSC-derived stem cells on a special membrane can help repair full-thickness skin defects.

research Single-stage transplantation combined with epidermal stem cells promotes the survival of tissue-engineered skin by inducing early angiogenesis

11 citations , March 2023 in “Stem Cell Research & Therapy”

Epidermal stem cells improve skin graft survival by promoting early blood vessel formation.

research Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration

March 2026 in “Gels”

The new biomimetic skin heals wounds faster and better than traditional treatments, without scarring.

Successful Allogeneic Epidermal Grafting of Chronic Recessive Dystrophic Epidermolysis Bullosa Wounds from Hematopoietic Cell Donors in the Outpatient Setting

research 577 Successful allogeneic epidermal grafting of chronic recessive dystrophic epidermolysis bullosa wounds from hematopoietic cell donors in the outpatient setting

April 2019 in “Journal of Investigative Dermatology”

Skin grafts from related donors significantly healed chronic wounds in patients with a severe skin condition over a year.

research A perfusable vascularized full-thickness skin model for potential topical and systemic applications

21 citations , April 2021 in “Biofabrication”

The study created a skin model with realistic blood vessels that improves skin grafts and testing for drug delivery.

research The Use of Therapeutic Peptides in Combination with Full-Thickness Skin Columns to Improve Healing of Excisional Wounds

1 citations , August 2025 in “Bioengineering”

Combining FTSC with TSN6 peptide greatly improves wound healing.

research Lysine Carboxymethyl Cysteinate (LCC) Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy

April 2026 in “Biology”

Lysine carboxymethyl cysteinate (LCC) protects skin from UVB damage by activating autophagy.

research Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model

30 citations , October 2013 in “BMC dermatology”

VEGF gel increases hair growth but may have potential toxicity.

research Exosomes from Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts to Bridge Rat Facial Nerve Defects

December 2022 in “Stem Cells and Development”

Exosomes from stem cells help improve nerve repair in rats.

research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

3 citations , October 2021 in “PLoS ONE”

Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.

Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

research Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

84 citations , January 2018 in “Biomaterials Science”

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.