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GlossaryEpithelial Proliferation

process where skin cells multiply and increase in number

Epithelial proliferation refers to the process by which epithelial cells, which form the outer layer of skin and line various organs and structures in the body, multiply and increase in number. This process is crucial for wound healing, tissue regeneration, and maintaining the integrity of barriers against pathogens. In the context of hair, epithelial proliferation is important for the growth and regeneration of hair follicles.

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research β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny

20 citations , December 2013 in “PLoS ONE”

β1 integrin is essential for the survival, growth, and movement of human epithelial progenitor cells.

research 1458 EMT-inhibiting transcription factor Ovol2 regulates directional cell migration and proliferation in adult skin epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition

19 citations , September 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.

research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation

30 citations , November 2018 in “EMBO Reports”

The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.

The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model

research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

16 citations , April 2016 in “PLoS ONE”

Negative pressure treatment improved skin thickness, blood vessel growth, and hair growth.

research 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation

April 2023 in “Journal of Investigative Dermatology”

MPZL3 protein helps control the size of oil glands and the growth of oil-producing cells in both mice and humans.

research Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice

28 citations , May 2000 in “Proceedings of the National Academy of Sciences”

The Walleye dermal sarcoma virus cyclin causes excessive skin cell growth in mice.

research Biological actions of oligomeric procyanidins: Proliferation of epithelial cells and hair follicle growth

8 citations , January 2001 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Oligomeric procyanidins may help hair grow by affecting cell growth and the hair growth cycle.

research Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

24 citations , July 2018 in “Stem cells”

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

research Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation

4 citations , August 2021 in “Annals of Translational Medicine”

Dihydroartemisinin helps reduce prostate enlargement in rats by stopping the growth of prostate cells.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

VEGF165 influences hair follicle cell growth and movement through VEGFR-2 activation.

Receptor Activator of NF-κB Stimulates the Proliferation of Epithelial Cells of the Epidermo-Pilosebaceous Unit

research Receptor activator of NF-κB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

60 citations , March 2011 in “Proceedings of the National Academy of Sciences of the United States of America”

RANK-RANKL signaling is essential for hair growth and skin health.

Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

research Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2

21 citations , November 2017 in “Scientific Reports”

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo11The authors disclosed conflict of interest.

79 citations , March 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.

research Polyphenols from the Heartwood ofCercidiphyllum japonicumand their Effects on Proliferation of Mouse Hair Epithelial Cells

26 citations , November 2002 in “Planta medica”

Extracts from Cercidiphyllum japonicum wood can stimulate mouse hair cell growth like common hair growth treatments.

research Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

17 citations , February 2018 in “Journal of Investigative Dermatology”

PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

research The germinative epithelium of sheep vibrissae and wool follicles has extensive proliferative potential but is dependent on the dermal papilla

1 citations , January 2012 in “International journal of trichology”

Sheep hair follicle cells can grow a lot but need the dermal papilla to do so.

research Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation

6 citations , September 2017 in “Experimental and Therapeutic Medicine”

Shortened PEDF peptides speed up skin wound healing by boosting cell growth.

research PD59-09 PHOSPHODIESTERASE INHIBITORS COULD REVERSE THE PROLIFERATION OF BPH EPITHELIAL CELLS INDUCED BY CD8+ T CELLS IN LOW ANDROGEN CONDITION

April 2018 in “The Journal of Urology”

Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.

Wnt7a Can Up-Regulate Cell Adhesion Related Protein Fibronectin Expression and Promote Cell Proliferation in Corneal Epithelial Cells

research Wnt7a can up-regulates cell adhesion related protein fibronectin expression and promotes cell proliferation in corneal epithelial cells

April 2023

Wnt7a helps corneal cells grow and stick together, aiding in repair.

research Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer

13 citations , September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

research The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation

88 citations , December 2003 in “Journal of Biological Chemistry”

Epiprofin helps cells grow in developing teeth, hair, and limbs.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

3 citations , December 2023 in “Aging”

hsa_circ_0002980 can help stop liver cancer cells from growing and spreading.

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

research Modulation of AR-FGF-2-TGF beta Axis by Cosmos caudatus Suppresses Prostatic Epithelial Proliferation in a BPH Rat Model: A Comparative Study with Finasteride

March 2026 in “Journal of Multidisciplinary Applied Natural Science”

Cosmos caudatus extract is as effective as finasteride for treating benign prostatic hyperplasia without its side effects.

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.