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GlossaryEpithelialization

process of new skin cells covering a wound

Epithelialization is the process by which new epithelial cells form and migrate to cover a wound or damaged tissue, creating a protective barrier. This is a crucial step in wound healing, as it helps to restore the integrity of the skin or mucous membranes, preventing infection and further injury.

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research A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin

13 citations , December 2001 in “Journal of Investigative Dermatology”

Overexpressing ornithine decarboxylase and v-Ha-ras in keratinocytes leads to invasiveness and malignancy.

research The Diameter Factor of Aligned Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization in an Immune Way

1 citations , February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

A300 membranes help skin heal faster by promoting cell growth and repair.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

research Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

research Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis

37 citations , December 2018 in “Frontiers in Immunology”

Biodegradable microparticles help wounds heal without scars.

research Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization

24 citations , January 2023 in “Frontiers in Medicine”

Moist Exposed Burn Ointment speeds up healing of diabetic wounds.

research Re-epithelialization of the skin following CO 2 laser resurfacing

20 citations , January 2001 in “Journal of Cutaneous Laser Therapy”

Occlusive dressings speed up skin healing after CO2 laser resurfacing.

research Follicular Isolation Technique with De-Epithelialization for Eyebrow and Eyelash Reconstruction

12 citations , September 2012 in “Plastic and Reconstructive Surgery”

Adding de-epithelialization to the follicular isolation technique improves hair transplant results for eyebrows and eyelashes.

research Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

8 citations , August 2023 in “Journal of Investigative Dermatology”

Corin speeds up wound healing by helping skin cells move and grow.

research Effect of De-epithelialization on Graft Survival Rate After Follicular Unit Extraction

1 citations , July 2021 in “Dermatologic Surgery”

Removing the outer layer of skin cells from hair grafts does not change the graft survival rate but may improve how it looks right after surgery.

research Negatively Charged Carbon Dot‐Linked Glycyrrhizic Acid Hydrogel Promoted Hemostasis, Immunoregulation and Re‐Epithelialization of Wound Closure

February 2026 in “Small”

The hydrogel speeds up wound healing and improves tissue repair.

research The Utility of De-epithelialization in Subcutaneous Skin Flap Transposition.

August 2025 in “PubMed”

De-epithelialization reduces complications in subcutaneous skin flap procedures.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

June 2022 in “PLOS ONE”

M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

December 2021

Myeloid cells can turn into skin and hair cells to help heal wounds.

research Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization

24 citations , March 2022 in “Stem Cell Research & Therapy”

Dendritic epidermal T cells help wounds heal faster by boosting skin stem cell growth.

research DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

22 citations , November 2016 in “International journal of molecular sciences”

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

8 citations , July 2023 in “Inflammation and Regeneration”

ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.

research Cultured Keratinocyte Sheets Enhanced Spontaneous Re-Epithelialization in a Dermal Explant Model of Partial-Thickness Wound Healing

42 citations , September 1990 in “Journal of Investigative Dermatology”

research The efficacy and safety of autologous epidermal cell suspensions for re‐epithelialization of skin lesions: A systematic review and meta‐analysis of randomized trials

10 citations , June 2024 in “Skin Research and Technology”

research The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing

8 citations , April 2013 in “Advances in Wound Care”

α3β1 integrin is essential for skin stability and proper wound healing.

research 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study

2 citations , January 2025 in “Brazilian Journal of Medical and Biological Research”

Vitamin D3 speeds up skin healing by helping skin stem cells grow and develop.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization

28 citations , March 2017 in “Endocrinology”

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

research Hedgehog signaling is essential for normal wound healing

112 citations , October 2008 in “Wound Repair and Regeneration”

Sonic hedgehog signaling is crucial for normal wound healing.

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

research A pilot clinical study of hair grafting in chronic leg ulcers

63 citations , October 2012 in “Wound Repair and Regeneration”

Hair follicle grafting can help heal chronic leg ulcers.

research Efficacy of Carbazole Alkaloids, Essential Oil and Extract of Murraya koenigii in Enhancing Subcutaneous Wound Healing in Rats

57 citations , December 2012 in “Molecules”

Murraya koenigii extract and mahanimbicine significantly speed up wound healing in rats.

research Fabrication of Electrospun Probiotic Functionalized Nanocomposite Scaffolds for Infection Control and Dermal Burn Healing in a Mice Model

34 citations , September 2019 in “ACS Biomaterials Science & Engineering”

Probiotic nanoscaffolds significantly improved burn healing and infection control in mice.

research Platelet‐rich plasma, a powerful tool in dermatology

33 citations , February 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Platelet-Rich Plasma (PRP) shows promise for treating various skin conditions, but more research is needed to standardize its use.

Design of an Artificial Skin. IV. Use of Island Graft to Isolate Organ Regeneration from Scar Synthesis and Other Processes Leading to Skin Wound Closure

research Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure

13 citations , March 1998 in “Journal of Biomedical Materials Research”

Island grafts can help study skin regeneration separately from other healing processes.