February 2024 in “Epigenomes” Epigenetic mechanisms control skin development by regulating gene expression.
February 2017 in “International Journal on Advanced Science, Engineering and Information Technology” Human hair follicle stem cells can grow and turn into skin cells on chitosan templates, which may help in regenerative medicine.
1160 citations
,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
178 citations
,
August 2016 in “Advances in wound care” New effective scar treatments are urgently needed due to the current options' limited success.
33 citations
,
February 2024 in “International Journal of Molecular Sciences” Understanding fibroblast issues in diabetic foot ulcers is key to creating better treatments.
28 citations
,
September 2020 in “International Journal of Molecular Sciences” Leucocyte-rich platelet-rich plasma boosts cell activity and helps wound healing.
21 citations
,
December 2023 in “Bioengineering & Translational Medicine” Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
16 citations
,
March 2024 in “International Journal of Molecular Sciences” Natural compounds and biomimetic engineering can improve wound healing by enhancing fibroblast activity.
1 citations
,
October 2025 γδ T cells help control tissue scarring and blood vessel growth in response to foreign objects.
Reprogramming adult fibroblasts may enable scar-free healing.
January 2026 in “Preprints.org” Mimicking fetal wound environments may enable scarless healing in adults.
January 2026 in “Burns & Trauma” NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.
December 2025 in “Nature Communications” Skin organoids can model tuberculosis infection and help test treatments.
September 2023 in “Çukurova medical journal (Online)/Çukurova medical journal” EZH2 levels decrease as fetuses develop and are higher in adult skin, which may affect skin growth and repair.
June 2023 in “Research Square (Research Square)” Hyaluronic acid and polycaprolactone improve skin regeneration, with polycaprolactone having a stronger effect on healing and tissue repair.
April 2020 in “Research Square (Research Square)” Exosomes from stem cells help wounds heal faster by affecting specific cell signals.
33 citations
,
September 2016 in “British journal of dermatology/British journal of dermatology, Supplement” Human hair follicle dermal cells can effectively replace other cells in engineered skin.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.
April 2026 in “Journal of Investigative Dermatology” Mechanotransduction aids healthy wound healing by promoting specific fibroblasts.
262 citations
,
May 2017 in “Nanomedicine” New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.
46 citations
,
June 2015 in “Journal of Investigative Dermatology” Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.
35 citations
,
October 2017 in “Signal Transduction and Targeted Therapy” Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.
8 citations
,
January 2022 in “Burns and trauma” Skin cell-derived vesicles can help heal skin injuries effectively.
5 citations
,
June 2024 in “Developmental Cell” Activating TRPV1 can boost hair growth by involving neurons, macrophages, and fibroblasts.
February 2026 in “Plastic and Aesthetic Research” Regenerative aesthetic medicine aims to restore tissue function, but needs more consistent evidence and standardized practices.
759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
418 citations
,
January 2018 in “Journal of Investigative Dermatology” Researchers found four distinct fibroblast types in human skin, which could help in treating wounds and fibrotic diseases.
359 citations
,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
314 citations
,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
308 citations
,
September 2010 in “Nucleic acids research” Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.