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GlossaryJAK-STAT pathway

transmits signals from cell surface to nucleus for gene expression

The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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research Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

55 citations , October 2019 in “Dermatology and therapy”

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

research An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

40 citations , August 2022 in “Frontiers in immunology”

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

research Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review

17 citations , May 2019 in “BMJ Open”

JAK/STAT inhibitors show promise for skin diseases but aren't yet approved.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product

research 570 Targeting JAK/STAT and Wnt/b-catenin pathways and 5a-reductase activity to develop an effective anti-hair loss product

November 2022 in “Journal of Investigative Dermatology”

The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research The JAK/STAT signaling pathway: from bench to clinic

489 citations , November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Baricitinib-Loaded EVs Promote Alopecia Areata Mouse Hair Regrowth by Reducing JAK-STAT-Mediated Inflammation and Promoting Hair Follicle Regeneration

research Baricitinib-loaded EVs promote alopecia areata mouse hair regrowth by reducing JAK-STAT-mediated inflammation and promoting hair follicle regeneration

December 2024 in “Drug Discoveries & Therapeutics”

Baricitinib-loaded EVs help hair regrowth in alopecia areata by reducing inflammation and promoting hair follicle regeneration.

research JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

223 citations , September 2018 in “Rheumatology”

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

research Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus

16 citations , January 2020 in “Annals of the rheumatic diseases”

Baricitinib might help treat hair loss in lupus patients, but more research is needed.

research Under Development JAK Inhibitors for Dermatologic Diseases

14 citations , January 2020 in “Mediterranean Journal of Rheumatology”

New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.

research JAK Inhibitors: A New Weapon in the Skin Care Providers' Arsenal.

8 citations , March 2023 in “PubMed”

JAK inhibitors show promise in treating difficult skin diseases.

research Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors

6 citations , November 2022 in “Journal of autoimmunity”

JAK inhibitors like tofacitinib may effectively treat Alopecia Areata.

research Jak inhibitors in the treatment of alopecia areata - a literature review

June 2025 in “Journal of Education Health and Sport”

Oral JAK inhibitors show promise for treating alopecia areata but have challenges like relapse and side effects.

The Role of JAK Inhibitors in Alopecia Areata: Literature Review

research El papel de los inhibidores de JAK en la alopecia areata: revisión de la literatura

December 2022 in “Revista Medicina Cutánea Ibero-Latino-Americana”

JAK inhibitors help treat alopecia areata but have high recurrence after stopping.

research Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo

March 2017 in “Current dermatology reports”

Topical JAK inhibitors can effectively treat alopecia areata and vitiligo by modulating immune responses.

research APECED: JAK Inhibition in an Adult Case with Long-Term Follow-up

December 2025 in “Journal of Human Immunity”

JAK inhibitors may help improve symptoms in adults with APECED.

research Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature

40 citations , December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

research Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

3 citations , July 2023 in “International journal of molecular sciences”

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

research A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata

June 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)”

JAK inhibitors show promise for treating alopecia areata but their effectiveness and safety are still debated.

Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research 700 Oncostatin M is upstream of JAK-STAT signaling during the murine hair cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

research Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications

July 2025 in “Preprints.org”

Specific miRNA profiles can help diagnose and treat alopecia areata.

research Natural Compounds Targeting MAPK, PI3K/Akt, and JAK/STAT Signaling in Papillary Thyroid Cancer

1 citations , October 2025 in “International Journal of Molecular Sciences”

Natural compounds may help treat advanced papillary thyroid cancer by targeting specific molecular pathways.

Alopecia Areata: Overview and Insights from January 2018

research Alopecia areata

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research The stem cell niche

209 citations , October 2008 in “The Journal of Pathology”

Stem cell niches are essential for tissue health and repair.

research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

124 citations , October 2019 in “Frontiers in Immunology”

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.