research Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation
Peptide-based PROTACs show promise in targeting hard-to-treat proteins, especially for cancer therapy.
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90-120 / 1000+ resultsresearch Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia
Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.
research Systemic Circulating Leptin – Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism
High leptin levels may promote skin cancer and inflammation, suggesting potential for leptin-targeted therapies.
research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets
Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.
research A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds
A new wound dressing helps heal diabetic wounds faster by reducing inflammation and promoting tissue growth.
research Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia
The new delivery system improves treatment for hair loss by enhancing drug absorption and effectiveness.
research Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction
Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.
research Alopecia Androgenética Feminina em Paciente Idosa: Relato de Caso com Protocolo Regenerativo Integrativo e Modulação de Senescência
The treatment improved hair density and scalp coverage in an elderly woman with hair loss.
research Alopecia Androgenética Feminina em Paciente Idosa: Relato de Caso com Protocolo Regenerativo Integrativo e Modulação de Senescência
The treatment improved hair density and scalp coverage in an elderly woman with hair loss.
research Thermo‐Responsive Polymer‐Based Nanoparticles: From Chemical Design to Advanced Applications
Thermo-responsive polymers in nanoparticles enable targeted drug delivery and advanced therapies by releasing drugs at specific temperatures.
research Research Progress of Extracellular Vesicles-Loaded Microneedle Technology
Microneedles with extracellular vesicles show promise for treating various conditions with targeted delivery.
research Topical delivery of nanoemulsions for skin cancer treatment
Nanoemulsions can effectively treat skin cancer with fewer side effects.
research Prostaglandins and Skin Cancer: An Old Pathway With New Insights in Cutaneous Oncology
Prostaglandin E2 promotes skin cancer, but certain supplements and drugs may help reduce risk and improve treatment.
research Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions
Skin bacteria help heal wounds and restore healthy skin.
research RNA modifications: molecular orchestrators of wound healing
RNA modifications help heal wounds and could lead to new treatments.
research Nanotechnology-based techniques for hair follicle regeneration
Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.
research Cold Plasma An emerging technology for clinical use in wound healing
Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.
research Treatment Strategies for Cutaneous and Oral Mucosal Side Effects of Oncological Treatment in Breast Cancer: A Comprehensive Review
Early detection and multidisciplinary management of skin and mouth side effects from breast cancer treatments improve patient outcomes.
research A systematic summary of survival and death signalling during the life of hair follicle stem cells
The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging
Epigenetic and metabolic changes affect stem cell function and aging in skin.
research Autophagy Dysfunction: The Kernel of Hair Loss?
Manipulating cell cleanup processes could help treat hair loss.
research Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance
Understanding phenotypic plasticity is crucial for developing effective cancer therapies.
research Eph/ephrin signaling in epidermal differentiation and disease
Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.
research Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems
Ionizable lipid nanoparticles are the best for delivering gene-editing therapies.
research Overlapping features of atopic dermatitis and alopecia areata: from pathogenesis to treatment
Atopic dermatitis and alopecia areata share immune and genetic factors, and targeted therapies may help both.
research Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
Type-2 immunity may influence skin diseases and could be targeted for treatment.
research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
research Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms
Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.
research Molecular mechanisms of viral oncogenesis in humans
Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.
research Emerging nonmetabolic functions of skin fat
Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.