research Delayed Collagen Production without Myofibroblast Formation Contributes to Reduced Scarring in Adult Skin Microwounds
Microthermal wounds heal with less scarring due to delayed collagen production and minimal inflammation.
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60-90 / 1000+ resultsresearch Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis
Inflammation in rheumatoid arthritis increases steroid activation in cells, reducing inflammation.
research Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study
Immune cells and cytokines significantly affect pathological scar development.
research ANALYSIS OF THE BACKGROUND LEVEL OF CYTOKINES M1 AND M2 OF THE MACROPHAGE PHENOTYPE IN PATIENTS WITH REVISION RHINOPLASTY AFTER THE USE OF THE DRUG PDRN
PDRN may reduce inflammation and complications in revision rhinoplasty for patients with high fibrinogen levels.
research Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing
Deep skin fibroblasts help recruit immune cells for better wound healing.
research Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers
PCOS is linked to inflammation, and certain markers could help in its treatment.
research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17
CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.
research Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage
Inflammasome proteins can predict inflammation and outcomes in aneurysmal subarachnoid hemorrhage.
research Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States
Microvascular damage and platelet issues persist in ulcerative colitis remission, helping assess disease states.
research Multi-omics empowered deep phenotyping of ulcerative colitis
Ulcerative colitis involves immune activation, chronic inflammation, and metabolic issues, some of which persist even during remission.
research 1497 Type 2-mediated oxidative reprogramming promotes the transition of macrophages into repair mode and is required for wound healing
Type 2 inflammation helps wound healing by switching immune cells to repair mode.
research MicroRNAs in the skin: role in development, homoeostasis and regeneration
MicroRNAs are important for skin health and could be targets for new skin disorder treatments.
research Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis
Reprogramming macrophages to resolve inflammation can help reduce severe COVID-19 complications.
research Increased Macrophage Migration Inhibitory Factor (MIF) in the Sera of Patients with Extensive Alopecia Areata
Patients with severe alopecia areata have higher levels of MIF, which decrease after successful treatment.
research Proteomic Analysis to Identify Prospective Biomarkers of Treatment Outcome After Microvascular Decompression for Trigeminal Neuralgia: A Preliminary Study
Certain proteins might predict surgical success in trigeminal neuralgia treatment.
research eLife assessment: Decoding the complexity of delayed wound healing following Enterococcus faecalis infection
Enterococcus faecalis delays wound healing by disrupting cell functions and creating an anti-inflammatory environment.
research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice
Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.
research Selective Expression of Chemokine Monokine Induced by Interferon-γ in Alopecia Areata
Targeting MIG and MCP-1 may help treat inflammation in alopecia areata.
research Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts
Centipeda minima and brevilin A protect skin cells from damage and aging.
research Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases
Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.
research Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities
Tissue remodeling involves structural and functional changes in organs, regulated by complex signaling networks. Canonical pathways like the TGF-β superfamily, growth factors, and the MMPs/TIMPs system are crucial for extracellular matrix turnover and fibroblast activation, influencing the inflammatory microenvironment. Recent insights reveal the importance of mechanical signals via the integrin-YAP/TAZ axis and metabolic reprogramming through the glycolysis-HIF-mTOR axis, which provide energy for cell activation. Non-coding RNAs also play a significant role in refining these processes. This review integrates both traditional and new mechanisms to identify shared principles of pathological remodeling across organs, aiming to support the development of precision therapeutic strategies.
research 741 Identification of a specific subset of monocytes/macrophages that coordinates skin wound healing
A specific type of immune cells, called CD301b-expressing macrophages, are crucial for skin repair processes.
research Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation
Nucleic acids trigger chemokine production in skin cells, affecting skin inflammation.
research Biomechanical Factors in Psoriatic Disease: Defective Repair Exertion as a Potential Cause. Hypothesis Presentation and Literature Review
Defective repair processes may cause immune activation and inflammation in psoriatic disease.
research Commensal microbe regulation of skin cells in disease
research Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities
miRNAs could help diagnose and treat gouty arthritis.
research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation
Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.
research Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases
Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.
research Macrophage Related Chronic Inflammation in Non-Healing Wounds
Macrophage issues cause chronic wound inflammation, but therapies can help.
research Internal peacekeepers and external mediators: A new model of peripheral immune tolerance involving regulatory T cells and mesenchymal stem cells
Regulatory T cells and mesenchymal stem cells work together to prevent immune system overreactions and tissue damage.