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Did you mean Monocyte Chemoattractant Protein-1?

GlossaryMonocyte Chemoattractant Protein-1

signaling protein that attracts monocytes to inflammation sites

Monocyte Chemoattractant Protein-1 (MCP-1), also known as CCL2, is a signaling protein that plays a crucial role in the immune system by attracting monocytes, a type of white blood cell, to sites of inflammation or injury. This protein is important in the body's response to infection and tissue damage, but excessive MCP-1 activity can contribute to chronic inflammatory diseases.

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research Different Levels of EGF, VEGF, IL-6, MCP-1, MCP-3, IP-10, Eotaxin and MIP-1𝛼 in Adipose Derived Stem Cells (ADSCs) Secretome in Androgenetic Alopecia

January 2021

Higher levels of certain proteins in hair loss areas may help understand and treat hair loss.

research Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury

56 citations , November 2012 in “Endocrinology”

Vitamin D receptor is essential for proper skin healing after injury.

research Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis

1 citations , January 2025 in “Clinical Cosmetic and Investigational Dermatology”

Higher levels of certain proteins may increase or decrease rosacea risk.

research FC053 Pro-inflammatory cytokine cascade in human plucked hair

September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Anti-IL-1 treatments might help with certain types of hair loss in people with high inflammation.

research LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway

53 citations , April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

research Assessment of chemokines MIP-1α and MIP-1 βin Iraqi women with polycystic ovarian syndrome

1 citations , October 2023 in “Egyptian Journal of Immunology”

PCOS is linked to low-grade chronic inflammation.

COVID-19 and Androgenic Status: Do Testosterone or Dihydrotestosterone Have a Pivotal Role?

research COVID-19 and androgenic status: testosterone or dihydrotestosterone have a pivotal role?

January 2023 in “Journal of men's health”

Higher dihydrotestosterone may be linked to more inflammation in COVID-19 patients with low testosterone.

Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions

research Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions

14 citations , October 2021 in “Dermatology and Therapy”

UV exposure accelerates skin aging by altering elastin, leading to wrinkles.

Transforming Growth Factor-Beta in Stem Cells and Tissue Homeostasis

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

6 citations , June 2011 in “British Journal of Dermatology”

People with alopecia areata have higher levels of RBP4 protein and antibodies against it.

research CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17

32 citations , February 2024 in “The Journal of Experimental Medicine”

CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

Mesenchymal Stem Cells Paracrine Proteins From Three-Dimensional Dynamic Culture System Promoted Wound Healing in Third-Degree Burn Models

research Mesenchymal stem cells paracrine proteins from three‐dimensional dynamic culture system promoted wound healing in third‐degree burn models

July 2023 in “Bioengineering & translational medicine”

Mesenchymal stem cell proteins in a special gel improved healing of severe burns.

research Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

13 citations , October 2019 in “Journal of lasers in medical sciences”

CO2 laser treatment for aging skin significantly changes immune system-related genes.

research Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

48 citations , September 2020 in “Frontiers in Immunology”

Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

research Effective high-throughput isolation of enriched platelets and circulating pro-angiogenic cells to accelerate skin-wound healing

6 citations , April 2022 in “Cellular and Molecular Life Sciences”

Angio PRP speeds up skin wound healing and reduces inflammation.

research Candidate genes of SARS-CoV-2 gender susceptibility

27 citations , November 2021 in “Scientific Reports”

Men are more affected by COVID-19 due to differences in immune responses and protein expression.

research Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens

July 2025

Scalp psoriasis inflammation is mainly caused by bacteria-related triggers.

research Deep skin fibroblast-mediated macrophage recruitment supports acute wound healing

3 citations , August 2024

Deep skin fibroblasts help recruit immune cells for better wound healing.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research GPCRs as key regulators in wound healing

April 2026 in “Frontiers in Cell and Developmental Biology”

GPCRs are vital for wound healing by affecting cell growth and immune response.

research Mammalian Fetal Organ Regeneration

32 citations , January 2005 in “Advances in Biochemical Engineering / Biotechnology”

Fetal wounds heal without scarring because of different biological factors, which could help improve adult wound healing.

research Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata

4 citations , July 2025 in “Frontiers in Immunology”

Early intervention with JAK inhibitors may prevent alopecia areata progression.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

research Radiofrequency Currents Modulate Inflammatory Processes in Keratinocytes

3 citations , October 2024 in “International Journal of Molecular Sciences”

CRET therapy affects inflammation in skin cells by changing cytokine levels and activating certain proteins.

research Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

90 citations , February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Interleukin-1 increases keratin K6 production in skin cells.

Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

research Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

4 citations , November 2021 in “Journal of Clinical Medicine”

Higher levels of CCL7 are linked to more severe hair loss in alopecia areata patients.