research Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation
Kdm6b is crucial for skin cell differentiation.
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360-390 / 1000+ resultsresearch Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders
CAR-T cell therapy shows promise for treating autoimmune disorders but faces challenges like complex manufacturing and limited tissue penetration.
research Antioxidant Natural Plant Constituents for Diabetic Wound Repair
Plant-based antioxidants can help heal diabetic wounds by reducing stress, infections, and inflammation.
research Progress on genome-wide association studies and selection signature analysis for agronomic traits in Chinese sheep and goats: review
Key genes linked to important traits in Chinese sheep and goats have been identified, but challenges remain in breeding improvements.
research Redefining Drug Discovery: A Review of Drug Repurposing –Approaches, Benefits and Breakthroughs
Drug repurposing finds new uses for existing drugs, speeding up treatment availability and reducing costs.
research Effective holistic characterization of small molecule effects using heterogeneous biological networks
Integrating biological networks improves drug repurposing and ADR prediction.
research Integrated analysis of transcriptomes and proteomes reveals the molecular mechanisms underlying the development of Dorper sheep hair follicles
research Untargeted hair lipidomics: comprehensive evaluation of the hair-specific lipid signature and considerations for retrospective analysis
research Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual’s drug responses
Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.
research 0750 Proteomics and transcriptomics profiling define molecular subtypes of advanced cutaneous T cell lymphoma and prognostic biomarkers
Three molecular subtypes of advanced skin T-cell lymphoma were identified, with potential biomarkers for predicting treatment response and disease progression.
research Integrated Transcriptome Analysis of lncRNA, miRNA, and mRNA Reveals key Regulatory Modules for Polycystic Ovary Syndrome
research Steroidomics for highlighting novel serum biomarkers of testosterone doping
Monitoring steroid hormones in blood can better detect testosterone doping.
research Protein Microarrays
Protein microarrays are highly sensitive tools useful for disease diagnosis and studying proteins.
research Topological Markers for Subcellular Chemical Mapping using TOF-SIMS
TOF-SIMS improved chemical mapping in cells, confirming gunshot residue, tracking anti-tumor drugs, and identifying molecules in mosquitoes and wounds.
research Hair follicle gene expression profiling in the SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS)
Hair follicles can be used to study gene expression and understand conditions like COPD.
research scMC learns biological variation through the alignment of multiple single-cell genomics datasets
scMC effectively separates biological signals from technical noise in single-cell genomics data.
research LC-APCI+-MS/MS method for the analysis of ten hormones and two endocannabinoids in plasma and hair from the mice with different gut microbiota
The method accurately measures hormones and endocannabinoids in mice, showing gut microbiota diversity affects these levels and may influence stress and reproductive systems.
research Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders
Hair proteomics could be a promising non-invasive way to identify stress-related disorders.
research Transcriptomic profiling of Arabidopsis Thaliana responses to Stutzerimonas stutzeri, chlorella vulgaris, and mixed consortium inoculation under salt stress
research Transforming 300 billion points of data into diagnostics, therapeutics and new insights into disease
Large data can lead to new medical discoveries and personalized medicine.
research Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism
The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.
research Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma
Multiphoton microscopy can effectively assess breast cancer treatment responses without labels.
research Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
Multitarget drugs are needed to better treat complex diseases.
research Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low‐volume, high‐intensity interval training
Hair follicle analysis can track body changes from high-intensity interval training.
research Transcriptome Analysis Methods: From the Serial Analysis of Gene Expression and Microarray to Sequencing new Generation Methods
RNA-Seq is now the standard for detailed gene expression analysis.
research scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data
scINSIGHT helps understand single-cell gene expression better than current methods.
research COMPATIBILITY OF BIOMAGNETIC PROFILES FOUND IN LIVING MATTER BY CROSS SPECIES DEMONSTRATION
New techniques can record electromagnetic fields in hair follicles for potential medical use.
research Optimal processing for proteomic genotyping of single human hairs
The method improved hair analysis for better forensic identification.
research A Powerful Method for Pleiotropic Analysis under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer
The new method found new shared genetic areas linked to both Type 2 Diabetes and Prostate Cancer.
research Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics
Hair protein analysis could improve medical testing and understanding of hair characteristics.