June 2025 in “Skin Appendage Disorders” Younger patients may see better results from PRP therapy for hair growth, but age doesn't significantly affect overall outcomes.
May 2025 in “Archives of Dermatological Research” Patient-reported hair improvements align with actual hair density changes, not hair width.
March 2025 in “Archives of Dermatological Research” Injectable minoxidil may be effective for hair loss but is costly and requires more research.
January 2025 in “Journal of the American Academy of Dermatology” Low-dose oral minoxidil alone is effective for treating hair loss, but combining it with dutasteride or finasteride may offer better results.
January 2025 in “International Journal of Dermatology”
November 2024 in “International Journal of Dermatology” Chemical treatments and tight hairstyles may lead to earlier hair loss.
22 citations
,
April 2018 in “Pharmaceutics” New methods improve how well skin treatments work by helping drugs get through the skin barrier.
8 citations
,
April 2012 in “Laser Physics Letters” Antiseptic particles penetrate deeper into hair follicles than non-antiseptic ones.
May 2025 in “Drug Delivery and Translational Research” 10 citations
,
December 2001 in “PubMed” The conclusion is that substances can penetrate hair fibers through multiple pathways, including both the cell membrane complex and the non-keratinous parts.
3 citations
,
April 2015 in “International research journal of pharmacy” Gentamicin penetrates pig skin better through open hair follicles than blocked ones.
90 citations
,
November 2014 in “Journal of Biomedical Optics” Silver nanoparticles can penetrate porcine skin up to about 15.6 μm, possibly through hair follicles.
1 citations
,
July 2017 in “Microscopy and Microanalysis” Iron oxide nanoparticles mainly enter the skin through hair follicles and sebocytes, not the dermis.
46 citations
,
May 2006 in “Laser Physics” Particles similar in size to hair cells penetrate hair follicles better.
2 citations
,
May 2011 in “Hair transplant forum international” The Intruder is a tool used for safely preparing the area where a donor's tissue is taken.
Hair follicles can effectively absorb nano-sized particles, making them potential targets for localized drug delivery.
26 citations
,
May 2012 in “Pharmaceutical Development and Technology” PEVs effectively deliver minoxidil through skin.
10 citations
,
August 2015 in “Journal of biophotonics” Hair follicles help substances penetrate the skin faster and more effectively.
16 citations
,
August 2014 in “Colloids and surfaces. B, Biointerfaces” Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.
November 2005 in “CRC Press eBooks” SEPA 0009 is a promising and safe skin penetration enhancer for topical use.
106 citations
,
June 1990 in “Journal of Investigative Dermatology” 55 citations
,
March 2018 in “Journal of pharmacy & pharmaceutical sciences” Microneedles help improve drug delivery through the skin and are used in medicine and beauty treatments.
19 citations
,
April 2013 in “Drug Development and Industrial Pharmacy” Hair follicles are important for the absorption of certain drugs into the skin.
66 citations
,
February 1985 in “Archives of dermatological research” Hair dyes penetrate the scalp very minimally, less than 1%.
54 citations
,
October 2002 in “Journal of controlled release” Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.
15 citations
,
October 2020 in “European journal of pharmaceutics and biopharmaceutics” Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.
3 citations
,
October 2021 in “Dermatologic Therapy” PRP with microneedling improves hair growth and patient satisfaction more than injections for androgenetic alopecia.
January 2026 in “International Journal of Applied Pharmaceutics” Nanoparticle-embedded microneedles improve drug delivery through the skin but face challenges in stability and safety.
10 citations
,
January 2014 in “Chemical and Pharmaceutical Bulletin” Ethanol pretreatment affects drug penetration through skin and hair follicles.
316 citations
,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.