research Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3
The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
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420-450 / 1000+ results research A clinico-pathological study of Neogynon as a new oral contraceptive steroid.
Neogynon effectively prevents pregnancy but may cause side effects like headaches and menstrual changes.
research Human dermal fibroblast‐derived secretory proteins for regulating nerve restoration: A bioinformatic approach
Human dermal fibroblast proteins help restore nerves during healing.
research 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells
Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.
research Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride
research Molecular interactions of natural and synthetic steroids in female hamsters’ flank organs
Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.
research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione
A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
research Miscellaneous Steroids
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
research Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)
Human skin can produce steroids from cholesterol.
research Steroid 5α-Reductase Inhibitors
New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.
research (Neuro-)endocrinology of epithelial hair follicle stem cells
Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
research Sex Steroid Hormone Receptors in Human Skin Appendage and its Neoplasms
Sex steroids influence skin appendage function and neoplasm development, with changes in AR and ERalpha in certain gland neoplasms.
research Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
research The profile of steroid hormones in human fetal and adult ovaries
Fetal ovaries produce different hormones than adult ovaries, and endocrine-disrupting chemicals may affect this process.
research Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery
Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.
research Progesterone and its Metabolites: Anticonvulsant and Behavioral Studies
Progesterone and its metabolites can prevent seizures without major side effects.
research Cutaneous neuroimmunology – lessons from the hair follicle
Stress and certain chemicals affect hair growth by interacting with the immune and nervous systems.
research Respiratory regulation by steroids in newborn rats: a sex‐specific balance between allopregnanolone and progesterone receptors
Breathing in newborn rats is affected differently by hormones based on their sex.
research Neuropsychiatric Reactions to Finasteride: Nocebo or True Effect?
research Synthesis of a 4-azasteroid hormones compound
Finasteride was successfully synthesized from Pregnadienolone acetate.
research Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling
Progesterone can reduce seizures without relying on the GABAA receptor pathway.
research Pharmacological Profile of 9,11-Dehydrocortexolone 17α-Butyrate (CB-03-04), a New Androgen Antagonist with Antigonadotropic Activity
CB-03-04 shows promise as a treatment for prostate issues due to its strong anti-androgen effects.
research Progesterone regulates corticosterone elevation and alterations in spatial memory and exploratory behavior induced by stress in Wistar rats
Progesterone helps protect against stress-related memory and behavior issues in rats.
research 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolism
24-Hydroxycholesterol reduces DHT formation in brain cancer cells, linking cholesterol and hormone metabolism.
research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways
Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.
research Determination of steroid hormones in human hair as a retrospective biomarker with HPLC-MS/MS
A new method accurately measures long-term hormone levels in hair.
research Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-lsomerase in Human Adrenals and Gonads
Human adrenals and gonads have a unique enzyme for steroid hormone production.
research Gonadal Sex Steroids: Production, Action and Interactions in Mammals
The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.
research Role of ciclosporin in steroid-responsive sudden sensorineural hearing loss
Ciclosporin might be a good alternative treatment for certain hearing loss that responds to steroids.
research 5. Novel anticonvulsant effects of supraphysiological doses of progesterone in hippocampal-kindled mice
High doses of progesterone can reduce seizures in mice.