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GlossaryPolycaprolactone

biodegradable polyester used in medical applications

Polycaprolactone (PCL) is a biodegradable polyester with a low melting point, commonly used in medical applications such as sutures, drug delivery systems, and tissue engineering scaffolds. Its biocompatibility and slow degradation rate make it particularly useful for long-term implants and controlled release of medications.

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research Fabrication and Characterization of Electrospun Membranes Based on “Poly(ε-caprolactone)”, “Poly(3-hydroxybutyrate)” and Their Blend for Tunable Drug Delivery of Curcumin

29 citations , September 2020 in “Polymers”

The PCL/PHB blend allows for slower, more controlled curcumin release than individual polymers.

research Biological properties of polycaprolactone and barium titanate composite in biomedical applications

17 citations , October 2023 in “Science Progress”

Polycaprolactone and barium titanate composites show promise for use in biomedical applications.

Cefazolin-Loaded Double-Shelled Hollow Mesoporous Silica Nanoparticles/Polycaprolactone Nanofiber Composites: A Delivery Vehicle for Regenerative Purposes

research Cefazolin-Loaded Double-Shelled Hollow Mesoporous Silica Nanoparticles/Polycaprolactone Nanofiber Composites: A Delivery Vehicle for Regenerative Purposes

6 citations , April 2022 in “Advanced Pharmaceutical Bulletin”

Cefazolin-loaded nanoparticles in nanofibers can help heal wounds and support regeneration.

In Vivo Hair Growth Promotion Effects of Cosmetic Preparations Containing Hinokitiol-Loaded Poly(ε-Caprolactone) Nanocapsules

research In vivohair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(ε-caprolacton) nanocapsules

32 citations , January 2008 in “Journal of Microencapsulation”

Cosmetics with hinokitiol-loaded nanocapsules were found to effectively promote hair growth.

research Electrospun Scaffold of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration

23 citations , November 2021 in “Journal of Bionic Engineering”

The new wound dressing helps skin heal faster and fights infection.

research Poly (ɛ‐caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds for skin excisional and burn wounds in a canine model

11 citations , January 2018 in “IET Nanobiotechnology”

The scaffolds significantly sped up wound healing in dogs and were safe.

Chondrogenic Differentiation of Human Scalp Adipose-Derived Stem Cells in Polycaprolactone Scaffold Using Freeze Thaw Freeze Method

research Chondrogenic differentiation of human scalp adipose‐derived stem cells in Polycaprolactone scaffold and using Freeze Thaw Freeze method

6 citations , January 2018 in “Journal of Cellular Physiology”

Human scalp fat stem cells showed improved cartilage-like development on a special scaffold with freeze-thaw treatment.

research Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers

4 citations , October 2017 in “Advances in tissue engineering & regenerative medicine”

Researchers created a potential skin substitute using a biodegradable mat that supports skin cell growth and layer formation.

research Efficacy and Safety of Polycaprolactone in Treating Nasolabial Folds: A Prospective, Multicenter, and Randomized Controlled Trial

12 citations , October 2022 in “Facial Plastic Surgery”

Polycaprolactone gel is effective and safe for treating nasolabial folds.

research Investigation of the effect of chitosan-polycaprolactone scaffolds loaded with chrysin-capped silver nanoparticles in the healing of experimental cutaneous wound defects in rat

July 2025 in “Journal of Translational Medical Research”

Chitosan-polycaprolactone scaffolds with chrysin-capped silver nanoparticles improve wound healing by reducing infection.

Comparison of MMP1 Gene Expression and Collagen Percentage in Response to Polydioxanone, Poly-L-Lactic Acid, and Polycaprolactone Thread Implantation in Aging Rat Skin

research Comparison of MMP1 gene expression and collagen percentage in response to polydioxanone, poly-L-lactic acid and polycaprolactone thread implantation in ageing rat skin

January 2025 in “Scripta Medica”

PDO, PLLA, and PCL threads increase collagen in ageing skin but don't change MMP1 gene expression.

Comparative Morphological Characterization of Skin after Subcutaneous Application of Hyaluronic Acid and Polycaprolactone in Rats: Establishment of an Experimental Model

research Comparative Morphological Characterization of Skin after Subcutaneous Application of Hyaluronic Acid and Polycaprolactone in Rats: Establishment of an Experimental Model

June 2023 in “Research Square (Research Square)”

Hyaluronic acid and polycaprolactone improve skin regeneration, with polycaprolactone having a stronger effect on healing and tissue repair.

A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(L-Lactide-Co-Caprolactone) for Endothelial Cells Delivery and Skin Wound Repair

research A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(l-lactide-co-caprolactone) for Endothelial Cells Delivery and Skin Wound Repair

16 citations , December 2018 in “ACS Biomaterials Science & Engineering”

The new patch made of cell matrix and a polymer improves wound healing and supports blood vessel growth.

Multifunctional Zinc-Doped Hollow Mesoporous Silica/Polycaprolactone Electrospun Membranes with Enhanced Hair Follicle Regeneration and Antibacterial Activity for Wound Healing

research Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing

76 citations , January 2019 in “Nanoscale”

Created material boosts hair growth and kills bacteria for wound healing.

research Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

2 citations , June 2023 in “Pharmaceutics”

Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.

research Design and characterization of AgVO3-HAP/GO@PCL ceramic-based scaffolds for enhanced wound healing and tissue regeneration

1 citations , June 2025 in “Journal of Materials Science Materials in Medicine”

AgVO₃-HAp/GO@PCL scaffolds improve wound healing and tissue regeneration effectively.

research Bioactive Citrate-based Polyurethane Tissue Adhesive for Fast Sealing and Promoted Wound Healing

November 2023 in “Regenerative Biomaterials”

The new adhesive seals wounds quickly, works well in wet conditions, and helps with healing.

research Transdermal delivery of mixnoxidil with block copolymer nanoparticles

253 citations , June 2004 in “Journal of Controlled Release”

Smaller nanoparticles improve minoxidil delivery through hair follicles.

research Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure

87 citations , August 2017 in “Scientific Reports”

The nanofiber scaffolds improved skin wound healing by supporting cell growth and tissue repair.

Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

research Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

62 citations , March 2015 in “PLOS ONE”

Pre-seeding scaffolds with fibroblasts improves skin wound healing.

research Microporous Dermal-Like Electrospun Scaffolds Promote Accelerated Skin Regeneration

60 citations , February 2014 in “Tissue Engineering Part A”

Microporous scaffolds speed up skin healing and regeneration.

research Polymeric nanoparticles-embedded organogel for roxithromycin delivery to hair follicles

47 citations , July 2014 in “European Journal of Pharmaceutics and Biopharmaceutics”

Scientists created a gel with nanoparticles to deliver medicine to hair follicles effectively.

research Optimization of menthol-loaded nanocapsules for skin application using the response surface methodology

25 citations , July 2019 in “Journal of drug delivery science and technology”

Researchers created better skin-application menthol capsules that are stable, safe, and penetrate the skin quickly.

research Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles

18 citations , September 2021 in “Colloids and surfaces. B, Biointerfaces”

Nanoparticles can effectively deliver spironolactone to hair follicles for treating alopecia and acne.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers

12 citations , June 2023 in “International Journal of Molecular Sciences”

Innovative biomaterials show promise in healing chronic diabetic foot ulcers.

research A Simple Drug Delivery System for Platelet-Derived Bioactive Molecules, to Improve Melanocyte Stimulation in Vitiligo Treatment

12 citations , September 2020 in “Nanomaterials”

The new drug delivery system improves vitiligo treatment by enhancing melanocyte activity and viability.