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GlossaryRe-epithelialization

process of new skin cell growth over a wound

Re-epithelialization is the process by which new skin cells (epithelial cells) grow and cover a wound, helping it to heal. This is a crucial step in wound healing, as it restores the protective barrier of the skin, preventing infection and further injury. For professionals, it involves the migration, proliferation, and differentiation of keratinocytes to re-establish the epidermal layer.

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Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

research Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

40 citations , December 2015 in “Stem Cells International”

Mesenchymal stem cells help improve wound healing by reducing inflammation and promoting skin cell growth and movement.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

research Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

Thyroxine (T4) May Promote Re-Epithelialization and Angiogenesis in Wounded Human Skin Ex Vivo

research Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo

27 citations , March 2019 in “PLoS ONE”

Thyroxine (T4) may help heal skin wounds by promoting new skin and blood vessel growth.

research Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization

24 citations , January 2023 in “Frontiers in Medicine”

Moist Exposed Burn Ointment speeds up healing of diabetic wounds.

research Re-epithelialization of the skin following CO 2 laser resurfacing

20 citations , January 2001 in “Journal of Cutaneous Laser Therapy”

Occlusive dressings speed up skin healing after CO2 laser resurfacing.

research The efficacy and safety of autologous epidermal cell suspensions for re‐epithelialization of skin lesions: A systematic review and meta‐analysis of randomized trials

10 citations , June 2024 in “Skin Research and Technology”

Autologous epidermal cell suspensions speed up healing and reduce complications in skin lesion treatment but have limited impact on cosmetic outcomes.

research Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

8 citations , August 2023 in “Journal of Investigative Dermatology”

Corin speeds up wound healing by helping skin cells move and grow.

research Negatively Charged Carbon Dot‐Linked Glycyrrhizic Acid Hydrogel Promoted Hemostasis, Immunoregulation and Re‐Epithelialization of Wound Closure

February 2026 in “Small”

The hydrogel speeds up wound healing and improves tissue repair.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

June 2022 in “PLOS ONE”

M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

December 2021

Myeloid cells can turn into skin and hair cells to help heal wounds.

research Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization

24 citations , March 2022 in “Stem Cell Research & Therapy”

Dendritic epidermal T cells help wounds heal faster by boosting skin stem cell growth.

research DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

22 citations , November 2016 in “International journal of molecular sciences”

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

research Resting no more: re‐defining telogen, the maintenance stage of the hair growth cycle

120 citations , November 2014 in “Biological Reviews”

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

8 citations , July 2023 in “Inflammation and Regeneration”

ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.

research Cultured Keratinocyte Sheets Enhanced Spontaneous Re-Epithelialization in a Dermal Explant Model of Partial-Thickness Wound Healing

42 citations , September 1990 in “Journal of Investigative Dermatology”

research Hair regrowth in alopecia areata and re‐pigmentation in vitiligo in response to treatment: Commonalities and differences

11 citations , September 2024 in “Journal of the European Academy of Dermatology and Venereology”

Hair regrows faster in alopecia areata than skin re-pigments in vitiligo due to differences in stem cells and treatment effects.

research 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study

2 citations , January 2025 in “Brazilian Journal of Medical and Biological Research”

Vitamin D3 speeds up skin healing by helping skin stem cells grow and develop.

research Delayed Wound Healing in Keratin 6a Knockout Mice

149 citations , July 2000 in “Molecular and Cellular Biology”

Keratin 6a is important for quick wound healing from hair follicles.

Epithelial-To-Mesenchymal Transition in Cutaneous Wound Healing: Where We Are and Where We Are Heading

research FOXO1, TGF-β Regulation and Wound Healing

87 citations , September 2014 in “International Journal of Molecular Sciences”

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

research Human Wharton's Jelly Stem Cells and Its Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds

84 citations , August 2013 in “Journal of Cellular Biochemistry”

Human Wharton's jelly stem cells improve wound healing.

research Toll-Like Receptor Function in Acute Wounds

65 citations , May 2017 in “Advances in wound care”

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

research Skin wounds in the MRL/MPJ mouse heal with scar

51 citations , January 2006 in “Wound Repair and Regeneration”

MRL/MpJ mice's skin wounds heal with scars, unlike their ear wounds which can regenerate.