426 citations
,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
97 citations
,
May 2019 in “Frontiers in Cell and Developmental Biology” Abnormal ECM and immune cell interactions can cause skin diseases.
11 citations
,
January 2025 in “Regenerative Therapy” Tissue-engineered scaffolds help heal difficult wounds by supporting cell growth and repair.
1398 citations
,
May 2008 in “Histochemistry and Cell Biology” Keratins are crucial for cell stability, wound healing, and cancer diagnosis.
68 citations
,
December 2014 in “Cell Biochemistry and Function” Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.
1 citations
,
November 2023 in “Biomaterials advances” Sponges made of soy protein and β-chitin with human cells from hair or fat can speed up healing of chronic wounds.
December 2025 in “FEBS Open Bio” Long-term skin biopsy cultures can produce many fibroblasts that remain functional and can be reprogrammed.
May 2026 in “Cell Reports Medicine” FR-1 reduces skin scarring and promotes healing without harmful effects.
48 citations
,
July 2008 in “Acta Biochimica et Biophysica Sinica” Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
29 citations
,
March 2012 in “Stem Cell Research & Therapy” Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.
22 citations
,
October 2004 in “Journal of Investigative Dermatology” The gene causing hair loss and heart issues in rough coat mice is still unknown.
19 citations
,
June 2008 in “Journal of Investigative Dermatology” HPV genes in mice improve ear tissue healing by speeding up skin growth and repair.
6 citations
,
January 2016 in “Journal of Stem Cell Research & Therapy” Notch1 signaling is crucial for improving wound healing and skin regeneration by affecting stem cell behavior.
February 2026 in “Food Research International” Lactiplantibacillus plantarum ZJUIDS51 can help regrow hair and improve scalp health in androgenic alopecia.
129 citations
,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
August 2025 in “Journal of Polymer Science” AcD scaffolds improve tissue repair and regeneration by combining stem cells with a supportive matrix.
December 2025 in “VNU Journal of Science Medical and Pharmaceutical Sciences” PRP therapy is effective and safe for skin conditions like wound healing and hair loss.
33 citations
,
September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
58 citations
,
November 2013 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
35 citations
,
July 2022 in “Frontiers in Cell and Developmental Biology” Proper mTOR signaling is crucial for healthy skin and preventing skin diseases.
23 citations
,
January 2017 in “Journal of Functional Biomaterials” Biomaterials can help reduce skin scarring and improve wound healing.
8 citations
,
February 2025 in “Molecules” A bioink with 15% gelatin and 150 mM calcium chloride works best for 3D printing skin models.
2 citations
,
November 2023 in “Biomolecules” WNT signaling is crucial for skin development and healing.
October 2025 in “Cell Proliferation” IL10_ApoEVs improve skin healing and reduce scarring.
September 2025 in “Stem Cell Research & Therapy” EVs and CMs may safely improve skin lightening and rejuvenation, but more research is needed.
48 citations
,
March 2019 in “Frontiers in Physiology” Wounds on the face usually heal with scars, but understanding how some wounds heal without scars could lead to better treatments.
13 citations
,
March 2012 in “The Journal of Dermatology” Hair transplant surgery can rebuild muscle and nerve connections, allowing transplanted hairs to stand up like normal hairs.
4 citations
,
March 2017 in “Development” Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.
19 citations
,
October 2023 in “Bioengineering” tSVF is effective for treating inflammation-related conditions, with centrifugation being the best method for isolation.
9 citations
,
October 2024 in “Burns & Trauma” Air-liquid interface culture improves hair follicle development in skin organoids.