research Discovery of Nonsteroidal Androgens
Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.
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810-840 / 1000+ resultsresearch Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells
KDML105 bran extract may help with hair growth and prevent hair loss.
research Vitamin B<sub>3</sub> (niacin), B<sub>6</sub>, C, and iron intake are associated with the free androgen index, especially in normoandrogenic polycystic ovary syndrome
Vitamins B3, B6, C, and iron intake affect hormone levels in women with certain types of PCOS.
research Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network
This study analyzed 7,933 adverse event reports related to aromatase inhibitors (AIs) from the FDA Adverse Event Reporting System, covering data from 2004 to 2023. It identified 642 positive signals of adverse reactions, with specific concerns for each AI: anastrozole was linked to antiphospholipid syndrome, plantar fasciitis, and autoimmune pancreatitis; letrozole was associated with androgenetic alopecia, myosclerosis, and pneumonic herpes virus; exemestane was connected to infection reactivation, decreased thyroxine free, and atrial dilatation. Letrozole had the earliest onset of adverse events, followed by exemestane and anastrozole. The study underscores the importance of monitoring these adverse events in real-world clinical settings.
research Evaluation of ovarian reserve and function in female patients treated with oral isotretinoin for severe acne: an exploratory study
Oral isotretinoin for severe acne can change hormone levels but does not significantly affect ovarian function.
research A comparison of the cytotoxic effects of fatty acids on in vitro breast and prostate cell lines
DHA derivatives, especially didocosahexaenoin, effectively kill prostate cancer cells and may offer a safer cancer treatment option.
research Uso do espironolactona no tratamento da acne vulgar na mulher adulta: uma revisão integrativa
Spironolactone is an effective and safe treatment for acne in adult women.
research Wedelolactone: A Natural Anti-inflammatory Coumarin Derivative
Wedelolactone may help treat chronic diseases due to its strong antioxidant properties.
research A Comparative Study of Diane‐35 plus Spironolactone and Diane ‐35 Plus Finasteride in Cases of Hirsutism and Acne
Both Diane 35 combinations effectively and safely reduce hirsutism and acne, with potential for better results if treatment extends beyond 12 months.
research Contraceptive use in acne
Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.
research Finasteride Treatment of Female Pattern Hair Loss
Finasteride with oral contraceptive helps improve hair loss in premenopausal women.
research Effect of Citrullus colocynthis Schard on Testosterone-Induced Benign Prostatic Hyperplasia
Citrullus colocynthis fruit extract and its compound may help treat enlarged prostate.
research FC055 Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism
Spironolactone is more effective than finasteride in treating excessive hair growth in women.
research Stimulation of Hair Growth Effect by Fermented Ginsenosides Using Levilactobacillus brevis THK-D437
Fermented ginsenosides from kimchi bacteria may promote hair growth better than finasteride.
research Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams
research Effects of Yifa Compound Prescription on Human Hair Follicle Growth in Vitro
Yifa Compound Prescription helps hair follicles grow better in lab conditions.
research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2
The compound 4c effectively inhibits the enzyme linked to hair loss.
research Productos naturales de origen vegetal contra el COVID-19
More clinical trials are needed to confirm if plant-based products can effectively treat COVID-19.
research Relative binding affinity of novel steroids to androgen receptors in hamster prostate
New steroids were effective in blocking male hormone receptors in hamster prostates.
research Actualités du SOPK
Estrogen-progestin contraception lowers ovarian, endometrial, and colon cancer risk but may raise breast and cervical cancer risk, helps with menstrual and acne issues, and new methods are as effective as pills. Metformin helps overweight women with PCOS and insulin resistance, and dopamine agonists treat prolactinomas.
research Insulin resistance, nitric oxide, and fibrinogen levels in white hirsute women: Defining a new paradigm based on translational research
White hirsute women with PCOS have higher insulin resistance, but similar nitric oxide and fibrinogen levels compared to those with idiopathic hirsutism.
research Evidence of Increased 3‐Alpha‐Androstanediol Glucuronide in Female Pattern Alopecia: A Cross‐Sectional Observational Study Evaluating Ovarian, Adrenal, and Peripheral Androgens
Higher levels of 3α-diol G are linked to more severe female pattern hair loss.
research Collagen, Curcumin, and Glutathione to Enhance Dermal Health in Aging Women with Declining Estrogen Levels -A Narrative Review.
Collagen, curcumin, and glutathione can improve skin health in aging women with low estrogen.
research Synergistic effect of sorafenib with Platycladus orientalis (L) leaf extract on cervical cancer
Sorafenib and Platycladus orientalis leaf extract together effectively suppress cervical cancer cell growth.
research 5α-Reduced glucocorticoids: a story of natural selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research Eficacia en alopecia de un acondicionador anticaída con Serenoa serrulata y tocoferol. Estudio piloto
The conditioner with Serenoa serrulata and tocoferol helps reduce hair loss.
research The influence of Castanea sativa Mill. flower extract on hormonally and chemically induced prostate cancer in a rat model
Chestnut flower extract may help reduce prostate cancer growth.
research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
research 104 Flibanserin Subset Analyses and the Androgenics of Hypoactive Sexual Desire Disorder
Flibanserin's effectiveness for low sexual desire in premenopausal women may vary based on hormone levels, with normal hormone levels showing better responses.
research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands
Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.