5 citations
,
December 2018 in “Frontiers in Endocrinology” Differences in androgen receptor expression and tissue properties may lead to higher cryptorchidism risk in certain rats.
38 citations
,
October 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” 5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.
1 citations
,
September 2023 in “AACE clinical case reports” Testosterone pellets might work for transgender men's hormone therapy, but more research is needed.
November 2022 in “Journal of the Endocrine Society” Removing the ovarian tumor improved the woman's hormonal symptoms.
23 citations
,
July 2015 in “The Journal of Membrane Biology” Testosterone increases certain proteins in the uterus, reducing fluid volume.
July 2024 in “Biological and Clinical Sciences Research Journal” Hormonal therapy for transgender individuals carries health risks but is a personal choice.
6 citations
,
August 2020 in “JCRPE” A boy with a rare form of early puberty caused by a new gene mutation responded well to treatment aimed at reducing testosterone and preserving adult height.
July 2008 in “International journal of psychophysiology” Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.
1 citations
,
August 2019 in “Environmental Toxicology” Exposure to low doses of finasteride in the womb causes changes in the prostate of both male and female gerbils.
1 citations
,
June 2021 in “Revista de la Facultad de Ciencias Médicas de Córdoba” Postmenopausal virilization can be caused by ovarian hyperthecosis, treatable with surgery.
1 citations
,
November 2002 in “Endocrine practice” The patient's high testosterone was reduced by a medication that suppresses gonadotropin.
27 citations
,
April 2011 in “Folia Histochemica et Cytobiologica” DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.
October 2024 in “Journal of the Endocrine Society” Leydig cell tumors can cause high testosterone and symptoms in postmenopausal women, and removing them improves symptoms.
May 2021 in “Journal of the Endocrine Society” A woman developed male characteristics after using unregulated hormone therapy.
October 2024 in “Journal of the Endocrine Society” Estrogen alone can lower testosterone in some transfeminine people.
68 citations
,
February 2019 in “Urology” Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.
3 citations
,
July 2019 in “Case Reports in Obstetrics and Gynecology” A young woman's rare ovarian tumor was successfully removed, improving her hormonal symptoms.
1 citations
,
September 2019 in “Steroids” Two new mutations in the AR gene linked to severe androgen insensitivity were found.
169 citations
,
November 2009 in “The Journal of Clinical Endocrinology & Metabolism” Prepubertal girls have higher sex steroid levels than boys, possibly leading to earlier puberty.
October 2025 in “Journal of the Endocrine Society” Early physical exams are crucial for timely Klinefelter syndrome diagnosis.
November 2022 in “Journal of the Endocrine Society” A rare ovarian tumor caused high testosterone and excess hair in a woman, which was resolved after tumor removal.
April 2021 in “Journal of Investigative Dermatology” Transgender patients on hormone therapy experience more acne and hair loss, but less skin inflammation.
September 2024 in “Brazilian Journal of Case Reports” Clomiphene testing can help find ovarian causes of high testosterone in postmenopausal women.
2 citations
,
August 2023 in “Journal of Endocrinological Investigation” Excess maternal androgens can cause heart problems in offspring.
1 citations
,
October 2022 in “Curēus” Diagnosing simple-virilizing congenital adrenal hyperplasia can be difficult and requires thorough testing and expert advice.
April 2026 in “BMJ Case Reports” Leydig cell tumors can cause high testosterone in women and are treated by removing the ovaries.
24 citations
,
October 2012 in “The International Journal of Biochemistry & Cell Biology” Testosterone protects female heart cells from stress by activating estrogen receptors.
July 2024 in “Journal of Pediatric Endocrinology and Metabolism” Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.
5 citations
,
April 2014 in “International Journal of Pediatric Endocrinology” Prepubertal girls with hypertrichosis have more sensitive androgen receptors, leading to increased body hair growth.
March 2009 in “The Journal of Urology” Finasteride helps treat hair loss and prostate issues by blocking a hormone.