49 citations
,
May 2020 in “The Scientific World JOURNAL” Mesotherapy is a skin injection therapy used for pain and local conditions, with scientific support but needing more clinical trials.
20 citations
,
January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.
April 2026 in “IntechOpen eBooks” Burn injuries can cause long-term itching, skin color changes, and cancer risks, needing personalized treatment.
January 2024 in “Journal of Cosmetic Dermatology” Platelet-rich plasma may improve hair density and count in male pattern hair loss, but more high-quality research is needed.
31 citations
,
August 2022 in “Frontiers in Oncology” Photobiomodulation therapy helps manage cancer treatment side effects but needs more research for optimization.
August 2024 in “Journal of Cutaneous and Aesthetic Surgery” Microneedling radiofrequency significantly improves hair growth with minimal side effects.
3 citations
,
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” PRP improves short-term pain and function in shoulder injuries, but long-term benefits are unclear.
Stress can cause hair loss and trigger autoimmunity by damaging hair follicle cells.
September 2025 in “Medical Materials Research” Microneedles offer a painless, precise, and versatile method for drug delivery and disease treatment.
January 2024 in “Wiadomości Lekarskie” Shifting attention can reduce physical pain.
June 2026 in “Dermatology and Therapy” Botulinum toxin type A effectively reduces pain in hair loss disorders.
Using calvarial bone for maxilla augmentation is less painful and allows for single-procedure dental implants.
6 citations
,
February 2010 in “Journal of The American Academy of Dermatology” A woman had a rare skin condition with recurring painful nodules that heal in 6 weeks, often without needing treatment.
48 citations
,
February 2025 in “Nano-Micro Letters” Microneedles offer a promising, painless way to treat skin diseases but need improvements for better use.
144 citations
,
September 2006 in “Clinics in Dermatology” Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.
88 citations
,
January 2004 in “Journal of Neuroscience” Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.
8 citations
,
May 2018 in “Primary Care: Clinics in Office Practice” Doctors should use a detailed patient history and physical exam to diagnose joint pain, and consult a rheumatologist early for suspected autoimmune diseases.
2 citations
,
January 2025 in “Pharmaceutical Research” Angelica gigas Nakai root extracts may help with cancer, pain, memory loss, and metabolic issues.
December 2008 in “The American Journal of Cosmetic Surgery” Multi-pass laser skin treatments improved healing, reduced pain, and had no major complications.
Steatocystomas are harmless skin cysts that can vary in size and may sometimes cause itching or pain.
165 citations
,
September 2003 in “Toxicology and applied pharmacology” Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.
27 citations
,
January 2018 in “Curēus” Subcutaneous contraceptives can cause side effects like menstrual changes, headaches, weight gain, and pain at the implant site.
13 citations
,
March 2019 in “Pharmacology Research & Perspectives” In Singapore, most skin reactions to drugs were in females and Chinese, often caused by painkillers, antibiotics, and some other drugs, with serious cases linked to genetics.
5 citations
,
January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” Injecting platelet-rich plasma or applying it with a laser or microneedling can treat hair loss effectively. The laser and microneedling methods cause less pain.
July 2020 in “Scholars journal of applied medical sciences” Sodium valproate caused vomiting, hair loss, loss of appetite, abdominal pain, weight gain, and anemia in young children with epilepsy.
26 citations
,
April 2006 in “Cephalalgia” Botulinum A toxin injections reduced pain and promoted hair regrowth in a woman with a rare form of alopecia areata.
September 2025 in “Clinical Cosmetic and Investigational Dermatology” Moderate exercise improves skin health, but intense exercise without protection can harm it.
61 citations
,
April 2023 in “Bioactive Materials” Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.
35 citations
,
November 2024 in “Gels” Hydrogel microneedles offer a painless, effective way to treat skin disorders.
8 citations
,
January 2025 in “JADA Foundational Science” Photobiomodulation therapy can reduce pain and inflammation and help heal tissues, but more research is needed to improve its effectiveness and safety.