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GlossaryType I Collagen

most abundant protein in skin, bones, and tendons

Type I Collagen is the most abundant collagen in the human body, making up about 90% of the collagen found in skin, bones, tendons, and other connective tissues. It provides structural support and strength, playing a crucial role in wound healing and maintaining the integrity of various tissues.

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research Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell

8 citations , February 2020 in “Journal of Drug Delivery Science and Technology”

Encapsulating chlorogenic acid in nanoparticles boosts type 17 collagen production, potentially aiding skin care.

research 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

Effects of Collagen Type XVII Alpha 1 on Epidermal Stem Cells in Aging Skin and the MicroRNA Intervention Mechanism

research [Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism].

September 2022 in “PubMed”

Collagen type XVII α1 decreases with age, leading to skin aging, but targeting microRNA-203b-3p may help maintain its levels and improve skin health.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Anti-aging effects of black raspberry extract on cataract, alopecia, skin whitening, and weight loss

10 citations , January 2018 in “Functional Foods in Health and Disease”

Black raspberry extract may help with hair growth, skin whitening, and weight loss.

research 520 The protective effects of Apocynin against ultraviolet B-induced cellular senescence in human keratinocytes

November 2022 in “Journal of Investigative Dermatology”

Apocynin may protect skin cells from aging and damage caused by UVB light.

Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

research Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue

8 citations , November 2019 in “Clinical Science”

High DHA levels delay wound healing and worsen skin repair quality.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

RCS-01 therapy is safe and may improve skin structure by affecting gene expression.

research Read-Through for Nonsense Mutations in Type XVII Collagen‒Deficient Junctional Epidermolysis Bullosa

5 citations , April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A new therapy for a skin blistering condition has not been developed yet.

research Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

December 2025 in “Pharmaceutics”

Araliadiol may help reduce skin aging and inflammation without killing cells.

research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

225 citations , April 2018 in “Journal of Investigative Dermatology”

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

8 citations , April 2017 in “Journal of Dermatological Science”

Hair loss is caused by the breakdown of a protein called COL17A1 in hair follicle stem cells.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

Type IV collagen chains vary in different parts of human skin, with specific patterns linked to melanocytes.

research Synergistic Effects of Fractional CO ₂ Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

January 2025 in “Dermatologic Therapy”

Combining fractional CO₂ laser with type III collagen improves acne scar treatment.

research Melanocytes from the Outer Root Sheath of Hair Follicles Cultivated on Collagen Membrane Improve their Melanotic Properties

5 citations , January 2012 in “Journal of Tissue Science & Engineering”

Collagen membranes improve melanocyte growth for treating skin depigmentation.

research Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

July 2025 in “Cosmetics”

Recombinant type XVII collagen may help regrow hair by activating specific cell pathways.

research Type XVII collagen coordinates proliferation in the interfollicular epidermis

124 citations , July 2017 in “eLife”

Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.

research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

12 citations , February 2023 in “Journal of Personalized Medicine”

Type 1 diabetes often occurs with other autoimmune diseases, and personalized treatment based on genetics can improve outcomes.

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

Tideglusib may help bone regeneration without being toxic at low doses.

research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

3 citations , October 2021 in “PLoS ONE”

Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.

research Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells

1 citations , May 2024 in “Journal of Dermatological Science”

Injecting specific cells into the skin can help improve skin structure and reduce blisters in a genetic skin disorder.

research Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting Type III collagen synthesis and hair follicle regeneration in skin injury

June 2025 in “Materials Today Bio”

A silk fibroin hydrogel boosts wound healing and hair growth by increasing collagen and hair follicles.

Identification of a Human Type XVII Collagen Fragment with High Capacity for Maintaining Skin Health

research Biological Macromolecule Hydrogel Based on Recombinant Type I Collagen/Chitosan Scaffold to Accelerate Full-Thickness Healing of Skin Wounds

12 citations , September 2023 in “Polymers”

The hydrogel speeds up skin wound healing effectively.

research Plasma-Polymerised Antibacterial Coating of Ovine Tendon Collagen Type I (OTC) Crosslinked with Genipin (GNP) and Dehydrothermal-Crosslinked (DHT) as a Cutaneous Substitute for Wound Healing

6 citations , March 2023 in “Materials”

The GNP crosslinked scaffold with antibacterial coating is effective for rapid wound healing and infection prevention.