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GlossaryWound Re-epithelialization

process where new skin cells cover a wound

Wound re-epithelialization is the process by which new skin cells (keratinocytes) migrate across a wound to restore the integrity of the skin barrier. This critical phase of wound healing involves the proliferation and movement of these cells to cover the wound surface, ultimately leading to the formation of new tissue and the closure of the wound.

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research DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

22 citations , November 2016 in “International journal of molecular sciences”

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

research Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

June 2022 in “PLOS ONE”

M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.

research Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis

37 citations , December 2018 in “Frontiers in Immunology”

Biodegradable microparticles help wounds heal without scars.

research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

8 citations , July 2023 in “Inflammation and Regeneration”

ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

December 2021

Myeloid cells can turn into skin and hair cells to help heal wounds.

research Negatively Charged Carbon Dot‐Linked Glycyrrhizic Acid Hydrogel Promoted Hemostasis, Immunoregulation and Re‐Epithelialization of Wound Closure

February 2026 in “Small”

The hydrogel speeds up wound healing and improves tissue repair.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

Platelet-rich plasma speeds up skin wound healing.

research The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing

8 citations , April 2013 in “Advances in Wound Care”

α3β1 integrin is essential for skin stability and proper wound healing.

research Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration

8 citations , August 2023 in “Journal of Investigative Dermatology”

research 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study

2 citations , January 2025 in “Brazilian Journal of Medical and Biological Research”

Vitamin D3 speeds up skin healing by helping skin stem cells grow and develop.

research Cultured Keratinocyte Sheets Enhanced Spontaneous Re-Epithelialization in a Dermal Explant Model of Partial-Thickness Wound Healing

42 citations , September 1990 in “Journal of Investigative Dermatology”

research Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization

24 citations , January 2023 in “Frontiers in Medicine”

Moist Exposed Burn Ointment speeds up healing of diabetic wounds.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization

28 citations , March 2017 in “Endocrinology”

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

research Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

40 citations , December 2015 in “Stem Cells International”

Mesenchymal stem cells help improve wound healing by reducing inflammation and promoting skin cell growth and movement.

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

research Reflections on how wound healing-promoting effects of the hair follicle can be translated into clinical practice

43 citations , July 2014 in “Experimental Dermatology”

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

research Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models

5 citations , February 2022 in “International Journal of Molecular Sciences”

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

Dermal Papilla Cell-Derived Exosomes Promote Hair Follicle Regeneration During Wound Healing by Activating Wnt/Beta-Catenin Signaling Pathway

research Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway

February 2024 in “Research Square (Research Square)”

Tiny particles from skin cells can help grow new hair by activating a specific growth signal during skin healing.

research Proangiogenic and Collagen-Promoting Effects of a 70% Ethanol Extract of Grateloupia angusta in Cutaneous Wound Models

March 2026 in “International Journal of Molecular Sciences”

Grateloupia angusta extract helps heal wounds faster and improve skin repair.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

research Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

31 citations , December 2022 in “Cold Spring Harbor Perspectives in Biology”

Understanding cell transitions can lead to better wound healing treatments.

research Epithelial stem cells and implications for wound repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Epithelial-To-Mesenchymal Transition in Cutaneous Wound Healing: Where We Are and Where We Are Heading

research Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns

14 citations , January 2021 in “Scientific Reports”

Using micro skin tissue columns improves skin wound healing and reduces scarring.

research Nrf2-Mediated Expansion of Pilosebaceous Cells Accelerates Cutaneous Wound Healing

14 citations , December 2018 in “The American journal of pathology”

Activating Nrf2 in skin cells speeds up wound healing by increasing the growth of certain stem cells.