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GlossaryChronic Inflammation

long-term immune response causing tissue damage and disease

Chronic inflammation, also known as persistent inflammation, is a prolonged and often harmful immune response that can last for months or even years. Unlike acute inflammation, which is a short-term response to injury or infection, chronic inflammation can result from ongoing exposure to irritants, autoimmune disorders, or unresolved acute inflammation. This persistent state can lead to tissue damage and is associated with various diseases, including arthritis, cardiovascular disease, and certain types of alopecia.

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Chronic Inflammatory Diseases Stimulated by Current Lifestyle: How Diet, Stress Levels, and Medication Prevent Our Body from Recovering

research Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering

119 citations , January 2012 in “Nutrition & Metabolism”

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

research High‐Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia

3 citations , February 2016 in “Pediatric dermatology”

Strong skin creams work well for long-term scalp inflammation in Rapp-Hodgkin Ectodermal Dysplasia.

research Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

3 citations , September 2023 in “Frontiers in immunology”

Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.

research The Role of Polycystic Ovarian Syndrome in Chronic Inflammation, Psychological Health, and the Gut Microbiota State: A Case Report

January 2022 in “Journal of family medicine”

Polycystic Ovarian Syndrome (PCOS) can cause chronic inflammation, mental health issues, and changes in gut bacteria, but a holistic lifestyle change can significantly improve these conditions.

research Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms

July 2019 in “Cancer Research”

Bone marrow and hair follicle cells help form skin tumors, suggesting new treatment targets.

research Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms

July 2019 in “Tumor Biology”

Bone marrow-derived cells contribute to skin tumors, suggesting new treatment targets for non-melanoma skin cancers.

Increased Serum C-Reactive Protein Levels Imply Chronic Inflammation in Men with Benign Prostatic Hyperplasia and Predominant Storage Lower Urinary Tract Symptoms

research 1746 INCREASED SERUM C-REACTIVE PROTEIN LEVELS IMPLIES CHRONIC INFLAMMATION IS INVOLVED IN MEN WITH BENIGN PROSTATIC HYPERPLASIA AND PREDOMINANT STORAGE LOWER URINARY TRACT SYMPTOMS

April 2013 in “The Journal of Urology”

Higher CRP levels suggest chronic inflammation is linked to bladder-related urinary symptoms in men with enlarged prostates.

research Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis

7 citations , February 2019 in “Journal of pharmacological sciences”

Bazhengsan reduces inflammation and tissue growth in chronic prostatitis.

research Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

December 2025 in “Rare Metals”

Smart biomaterials and dressings show promise in treating chronic skin diseases by improving drug delivery and minimizing side effects.

research Insulin resistance and chronic inflammatory dermatoses

March 2024 in “Ukraïnsʹkij žurnal dermatologìï, venerologìï, kosmetologìï”

Insulin resistance significantly contributes to the development and severity of certain chronic skin diseases.

research Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren syndrome

6 citations , April 2012 in “Muscle & nerve”

Recognizing the link between certain autoimmune disorders and neurological conditions can improve diagnosis and treatment.

research A first case of childhood chronic inflammatory demyelinating polyneuropathy associated with alopecia universalis

August 2022 in “Brain and Development”

A nine-year-old girl with muscle weakness and total hair loss improved with specific treatments.

Hypothesis: Platelet-Rich Plasma as an Adjunct Therapy for Eczema Targeting Inflammation, Skin Barrier Repair, and Chronic Recurrence

research Hypothesis: platelet-rich plasma as an adjunct therapy for eczema targeting inflammation, skin barrier repair, and chronic recurrence

October 2025 in “Frontiers in Immunology”

Platelet-rich plasma might help treat eczema by reducing inflammation and repairing the skin.

research Abstract 5202: Bone marrow-derived epithelial cells contribute to chronic skin inflammation and skin tumor formation in the mouse

April 2012 in “Cancer Research”

Bone marrow-derived cells can lead to skin inflammation and tumors in mice.

research Effects of finasteride in patients with inflammatory chronic pelvic pain syndrome: a double-blind, placebo-controlled, pilot study

65 citations , March 1999 in “Urology”

Finasteride didn't significantly improve ICPPS symptoms, more research needed.

research Macrophage Related Chronic Inflammation in Non-Healing Wounds

228 citations , June 2021 in “Frontiers in Immunology”

Macrophage issues cause chronic wound inflammation, but therapies can help.

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

April 2019 in “PLOS ONE”

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

research Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases

59 citations , June 2022 in “Frontiers in medicine”

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study

research Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study

14 citations , February 2020 in “Stem Cells International”

Umbilical cord cells safely improve healing in long-term nonhealing wounds better than a placebo.

research Beta-trace protein in chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome – clinical utilization and a new insight into pathophysiological mechanisms

1 citations , February 2025 in “Journal of the Neurological Sciences”

Beta-trace protein may help diagnose and predict treatment response in certain nerve disorders.

research Formulation and Evaluation of Hair Gel for the Treatment of Chronic Inflammatory Disorder Seborrheic Dermatitis

January 2013

The HG3 hair gel is the most effective for treating seborrheic dermatitis.

research Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon α 2a therapy for chronic hepatitis C virus infection

39 citations , January 2008 in “World Journal of Gastroenterology”

Pegylated interferon-alpha 2a can cause a rare nerve disorder, but early treatment can lead to full recovery.

research The Versatile Applications of Triple‐Wavelength Diode Laser (810, 940, and 1060 nm) in Aesthetic Treatments, Follicular Disorders, and Chronic Inflammatory Conditions in the Asian Population: Case Report Collection

4 citations , June 2025 in “Journal of Cosmetic Dermatology”

research
The Inflammatory Aspect of Male and Female Pattern Hair Loss

9 citations , November 2020 in “Journal of Inflammation Research”

Inflammation affects hair loss; anti-inflammatory treatments may help.

research JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

8 citations , November 2024 in “EMBO Molecular Medicine”

Targeting JAK-STAT1 can reduce inflammation and promote hair growth in conditions linked to EGFR deficiency.

Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-Inflammatory and Endocrine Dysfunction: A Narrative Review

research Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-inflammatory and Endocrine Dysfunction: A Narrative Review

May 2026 in “Endocrine Connections”

Androgenetic alopecia in PCOS is linked to insulin resistance, inflammation, and genetics, not just hormones.

research The brain–gut–skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies

February 2026 in “Frontiers in Immunology”

Skin diseases like acne and psoriasis are linked to stress, gut health, and inflammation, with new treatments focusing on gut and mind-body approaches.

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Related Terms

Research

research Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering

research High‐Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp–Hodgkin Ectodermal Dysplasia

research Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

research The Role of Polycystic Ovarian Syndrome in Chronic Inflammation, Psychological Health, and the Gut Microbiota State: A Case Report

research Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms

research Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms

research 1746 INCREASED SERUM C-REACTIVE PROTEIN LEVELS IMPLIES CHRONIC INFLAMMATION IS INVOLVED IN MEN WITH BENIGN PROSTATIC HYPERPLASIA AND PREDOMINANT STORAGE LOWER URINARY TRACT SYMPTOMS

research Anti-inflammatory and anti-hyperplastic effect of Bazhengsan in a male rat model of chronic nonbacterial prostatitis

research Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

research Insulin resistance and chronic inflammatory dermatoses

research Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren syndrome

research A first case of childhood chronic inflammatory demyelinating polyneuropathy associated with alopecia universalis

research Hypothesis: platelet-rich plasma as an adjunct therapy for eczema targeting inflammation, skin barrier repair, and chronic recurrence

research Abstract 5202: Bone marrow-derived epithelial cells contribute to chronic skin inflammation and skin tumor formation in the mouse

research Effects of finasteride in patients with inflammatory chronic pelvic pain syndrome: a double-blind, placebo-controlled, pilot study

research Macrophage Related Chronic Inflammation in Non-Healing Wounds

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

research Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases

research Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study

research Beta-trace protein in chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome – clinical utilization and a new insight into pathophysiological mechanisms

research Formulation and Evaluation of Hair Gel for the Treatment of Chronic Inflammatory Disorder Seborrheic Dermatitis

research Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon α 2a therapy for chronic hepatitis C virus infection

research The Versatile Applications of Triple‐Wavelength Diode Laser (810, 940, and 1060 nm) in Aesthetic Treatments, Follicular Disorders, and Chronic Inflammatory Conditions in the Asian Population: Case Report Collection

research
The Inflammatory Aspect of Male and Female Pattern Hair Loss

research JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

research Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-inflammatory and Endocrine Dysfunction: A Narrative Review

research The brain–gut–skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies

research Silencing Inflammation: Nano-Antioxidants and Immunomodulators in PCOS Management

research Editorial: Inflammation, stem cells and wound healing in skin aging

research A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26