research Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer
Tryptanthrin effectively suppresses non-melanoma skin cancer and is safe for normal skin.
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research Resident macrophages of the lung and liver: The guardians of our tissues
Lung and liver macrophages protect our tissues and their dysfunction can cause various diseases.
research Skin fibroblast functional heterogeneity in health and disease
Different types of skin fibroblasts have unique roles in skin health and disease.
research 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes
Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.
research Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies
Targeting pyroptosis may offer new treatments for alopecia areata, but more research is needed.
research Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides
Targeting SIRT1 with antisense oligonucleotides could be a promising treatment for hair loss.
research The X Factor in Immunity: Sex Differences Shaped by the X Chromosome
Females generally have stronger immune responses than males due to the X chromosome.
research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
research Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages
Soluble CD83 speeds up wound healing and reduces scarring.
research Systematic Review: Allogenic Use of Stromal Vascular Fraction (SVF) and Decellularized Extracellular Matrices (ECM) as Advanced Therapy Medicinal Products (ATMP) in Tissue Regeneration
Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.
research Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair
NLRP3 helps control inflammation and repair in wound healing, making it a potential target for treatment.
research Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways
Myricetin shows promise as an anticancer agent by reducing inflammation and enhancing drug effectiveness.
research Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine
Bacterial extracellular vesicles could revolutionize regenerative medicine but need safety improvements.
research Regenerative Medicine
Regenerative medicine may offer long-lasting relief for chronic pain and neuro-degenerative conditions.
research Aberrant Activation of the Hedgehog Pathway in Cutaneous Melanoma: Therapeutic Potential of Pharmacological Inhibitors
Hedgehog pathway inhibitors could be effective in treating melanoma.
research Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.
research Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024
In 2024, the FDA approved 27 innovative small-molecule drugs, with many offering significant treatment improvements.
research Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review
Genetic screening for NUDT15 polymorphisms is crucial for patients taking azathioprine, especially in Asians.
research Mechanisms of Impaired Skeletal Muscle Regeneration and Therapeutic Approaches in Aging and Chronic Disease
Aging and chronic diseases impair muscle repair, but integrated therapies like exercise and gene editing may help.
research The Skin Microbiome: Current Landscape and Future Opportunities
The skin microbiome is crucial for skin health, and more research is needed to explore its role and potential treatments.
research Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Bioprinting is improving skin models for better testing of skin diseases without using animals.
research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
ALKBH5 helps wounds heal faster by stabilizing PELI2 mRNA.
research Chikungunya virus infection in the skin: histopathology and cutaneous immunological response
Chikungunya virus often causes skin issues and inflammation.
research Multimodal roles of transient receptor potential channel activation in inducing pathological tissue scarification
Targeting TRP channels may help reduce excessive scarring.
research Hair follicle-inspired therapies for wound healing and scar remodelling
Hair follicles can improve wound healing and reduce scarring.
research The Wound Healing: A Mystery Still to Be Solved—What Is the Future?
Wound healing is not fully understood, requiring more research and collaboration to improve treatments.
research ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease
ZNF750 helps keep hair follicles healthy and prevents skin inflammation.
research Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration
Blocking DPP4 can potentially speed up hair growth and regeneration, especially after injury or in cases of hair loss.
research The mechanical forces that shape our senses
Mechanical forces are crucial in shaping our sensory organs during development.
research Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks
CNVs influence hair length in Tianzhu white yaks.