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GlossaryDeoxycholic Acid

bile acid aiding fat digestion and absorption

Deoxycholic Acid, also known as DCA, is a bile acid that is naturally produced by the liver and stored in the gallbladder. It helps in the digestion and absorption of fats in the small intestine. In medical and cosmetic applications, deoxycholic acid is used in treatments to break down and absorb fat cells, such as in the injectable treatment Kybella for reducing submental fat (double chin).

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Deoxycholic Acid in Submental Fat Reduction: A Review of Properties, Adverse Effects, and Complications

research Deoxycholic acid in the submental fat reduction: A review of properties, adverse effects, and complications

25 citations , July 2020 in “Journal of cosmetic dermatology”

Deoxycholic acid is effective for reducing chin fat but can cause side effects and serious complications, so careful patient evaluation is needed.

research Alopecia Following Deoxycholic Acid Treatment for Submental Adiposity

17 citations , August 2019 in “JAMA Facial Plastic Surgery”

Some men lost hair after deoxycholic acid treatment for neck fat, but most saw improvement or resolution.

research Assessing the Efficacy of Deoxycholic Acid for the Treatment of Submental Fat: A Three-Dimensional Study

7 citations , September 2018 in “Aesthetic surgery journal”

Deoxycholic acid effectively reduces double chin fat with temporary side effects and high patient satisfaction.

research Management of Serious Adverse Events Following Deoxycholic Acid Injection for Submental and Jowl Fat Reduction: A Systematic Review and Management Recommendations

5 citations , January 2024 in “Aesthetic Surgery Journal Open Forum”

Proper management and preventative measures can reduce serious adverse events from deoxycholic acid injections for fat reduction.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico and in vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

research Deoxycholic Acid for Submental Fullness and More

September 2018 in “Dermatologic Surgery”

research Vascular Injury After Deoxycholic Acid Injection

May 2018 in “Dermatologic Surgery”

research Anti-MRSA malleable liposomes carrying chloramphenicol for ameliorating hair follicle targeting

40 citations , November 2017 in “International journal of nanomedicine”

DA liposomes with chloramphenicol effectively target hair follicles and combat MRSA with minimal skin toxicity.

research Alopecia after injection of ATX-101 for reduction of submental fat

31 citations , May 2017 in “JAAD Case Reports”

ATX-101 injections can cause hair loss.

research Mesococktails and mesoproducts in aesthetic dermatology

11 citations , August 2020 in “Dermatologic therapy”

The document concludes that mesotherapy can be effective for skin and hair treatments, but more research is needed to confirm its safety and effectiveness.

research Lipolytic agents for submental fat reduction: Review

1 citations , January 2024 in “Skin research and technology”

Deoxycholic acid is FDA-approved for reducing submental fat, but its mechanisms are not fully understood.

research 12 Integrating Technology in Facial Plastic Surgery

January 2018

Surgeons should evaluate new technologies critically, offer a range of services including non-surgical options, and be aware of marketing influences to meet patient needs and maintain a successful practice.

research Effectiveness and Safety of a New Hyaluronic Acid Injectable for Augmentation and Correction of Chin Retrusion

March 2024 in “Journal of drugs in dermatology”

HASHA is a safe and effective option for chin augmentation.

research Alopecia Induced by Poly-L-Lactic Acid Injection

1 citations , November 2024 in “Cutis”

PLLA injections can cause hair loss and skin issues.

research Alopecia Induced by Poly-L-Lactic Acid Injection

November 2024 in “Cutis”

Poly-L-lactic acid injections can cause hair loss and skin issues.

research Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

18 citations , May 2024 in “Pharmaceutics”

Improved delivery systems can enhance oleanolic acid's effectiveness in treating various conditions.

research Obstetric Dermatology

January 2009 in “Springer eBooks”

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

research Nonsurgical Facial Esthetic Procedures

2 citations , March 2025 in “Otolaryngologic Clinics of North America”

Nonsurgical facial treatments are becoming more popular due to their natural-looking results and minimal invasiveness.

research JOLT: A Noninvasive Solution for the Correction of the Jowl

June 2024 in “Plastic & Reconstructive Surgery Global Open”

JOLT uses fillers to lift and tighten the lower face and neck.

research Medicinal Plants for Skin Disorders: Phytochemistry and Pharmacological Insights

4 citations , August 2025 in “Molecules”

Medicinal plants show promise for skin disorders but need more research for safe clinical use.

research Evolution and Trends of Facial Plastic Surgery and Facial Aesthetic Procedures in India: From Awakening to Revival

1 citations , January 2023 in “Aesthetic surgery journal”

Facial plastic surgeries and aesthetic procedures are becoming more popular in India, with a preference for non-surgical options and effective treatments for facial enhancement and hair loss.

research Very-long-chain Acyl-CoA Synthetases

191 citations , November 2007 in “Journal of Biological Chemistry”

Very-long-chain acyl-CoA synthetases and fatty acid transport proteins play key roles in fatty acid metabolism and lipid processing in different tissues.

research Expression of an Olfactomedin-Related Gene in Rat Hair Follicular Papilla Cells

10 citations , June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

FP-1 is a key protein in rat hair growth, active only during the growth phase.

research A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In vitro and In vivo Assessments

1 citations , January 2015 in “Journal of clinical and investigative dermatology”

IGF-1 from human placenta helps hair grow.

research Multi-omics empowered deep phenotyping of ulcerative colitis

1 citations , May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Ulcerative colitis involves immune activation, chronic inflammation, and metabolic issues, some of which persist even during remission.

research Non‐Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections

8 citations , November 2024 in “Journal of Cosmetic Dermatology”

Injections are effective and safe for rejuvenating neck, chest, and hands.

research Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications

6 citations , June 2024 in “Medical Review”

Biliary fibrosis is crucial in liver diseases and understanding it can help prevent and treat these conditions.

research Mesotherapy: myth and reality

3 citations , April 2011 in “Expert Review of Dermatology”

Mesotherapy lacks strong evidence for effectiveness and safety, and its ingredients are not FDA-approved for subcutaneous use.

research AAPS and PSRC 2016 Abstract Supplement

April 2016 in “Plastic and reconstructive surgery. Global open”

The supplement highlighted advancements and challenges in plastic and reconstructive surgery, including the impact of smoking, chemotherapy, and new treatments like Tafluprost for hair loss.

research T cell and bacterial microbiota interaction at intestinal and skin epithelial interfaces

January 2023 in “Discovery immunology”

T cells and bacteria in the gut and skin help maintain health and protect against disease.