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Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

research Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

June 2025 in “Journal of Cluster Science”

Metal nanoparticles show promise for treating hair loss but need more research to ensure safety.

research Nanotechnology-based techniques for hair follicle regeneration

October 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

research Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles

13 citations , September 2020 in “Sensors”

Hair follicles have a pH gradient, increasing towards the root.

research Potential of the Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile

6 citations , January 2025 in “Molecules”

Combining polymers and lipids may improve antioxidant delivery for wound healing, but practical challenges remain.

research Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

9 citations , January 2023 in “Langmuir”

Solubility in skin changes with hydration, affecting chemical absorption.

research Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science

298 citations , June 2019 in “Marine Drugs”

Chitosan is a sustainable, versatile ingredient in cosmetics, enhancing skin hydration and anti-aging while promoting eco-friendly practices.

research Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

205 citations , September 2018 in “Nutrients”

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

research Microneedles in the clinic

203 citations , May 2017 in “Journal of controlled release”

Microneedles are being used and tested for various medical and cosmetic treatments.

research Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm

110 citations , January 2014 in “Journal of Controlled Release”

Phospholipid-coated nanoparticles penetrate hair follicles better than others, especially in pig ears.

research Recent Advances in the Controlled Release of Growth Factors and Cytokines for Improving Cutaneous Wound Healing

88 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Bioengineered materials improve wound healing by releasing growth factors and cytokines more effectively than traditional methods.

research Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects

71 citations , June 2007 in “Bioorganic & Medicinal Chemistry Letters”

PLGA nanospheres improve hair growth by effectively delivering ingredients to hair follicles.

research Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles.

54 citations , December 2004 in “PubMed”

Cyclosporin A vesicles effectively regrow hair and reduce inflammation in alopecia areata.

research Smart Microneedles for Therapy and Diagnosis

46 citations , January 2020 in “Research”

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

Edar signaling is crucial for controlling hair growth and regression.

research Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing

40 citations , January 2022 in “Frontiers in Chemistry”

The patch speeds up deep wound healing.

research Evolution of Hair Treatment and Care: Prospects of Nanotube-Based Formulations

39 citations , June 2019 in “Nanomaterials”

Nanotube-based hair treatments could improve hair health and growth, and offer long-lasting effects.

Omega 3 Fatty Acid-Enriched Nanoemulsion of Thiocolchicoside for Transdermal Delivery: Formulation, Characterization, and Absorption Studies

research Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies

29 citations , June 2014 in “Drug delivery”

The new formulation improved the skin absorption of the drug Thiocolchicoside.

research Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

26 citations , January 2024 in “Gels”

Nanoemulgels could effectively treat skin diseases and may replace or complement current therapies.

research Effect of composite biodegradable biomaterials on wound healing in diabetes

25 citations , November 2022 in “Frontiers in Bioengineering and Biotechnology”

Composite biodegradable biomaterials can improve diabetic wound healing but need more development for clinical use.

research Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

18 citations , May 2024 in “Pharmaceutics”

Improved delivery systems can enhance oleanolic acid's effectiveness in treating various conditions.

Development of Optimized Self-Nanoemulsifying Lyophilized Tablets to Improve Finasteride Clinical Pharmacokinetic Behavior

research Development of optimized self-nanoemulsifying lyophilized tablets (SNELTs) to improve finasteride clinical pharmacokinetic behavior

15 citations , November 2017 in “Drug Development and Industrial Pharmacy”

Improved tablets lead to faster, better drug absorption for hair loss treatment.

research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One

10 citations , July 2022 in “Journal of Medicinal Chemistry”

Adding a second method to PROTACs could improve cancer treatment.

research Advances in clinical applications of microneedle

9 citations , June 2025 in “Frontiers in Pharmacology”

Microneedles improve drug delivery, patient compliance, and have potential in cancer treatment and skin care.

research
Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam For Scalp Psoriasis

9 citations , September 2019 in “Clinical Cosmetic and Investigational Dermatology”

Cal/BD aerosol foam effectively treats scalp psoriasis, improving symptoms and patient satisfaction.

research Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin

8 citations , December 2024 in “Frontiers in Medicine”

Damaged skin has a weakened barrier, making it more vulnerable to substances and inflammation.

research Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II – Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide

8 citations , November 2019 in “International Journal of Pharmaceutics”

The method improves acne treatment by enhancing drug delivery and reducing skin irritation.

research Nanoemulgel: For Promising Topical and Systemic Delivery

5 citations , April 2022 in “IntechOpen eBooks”

Nanoemulgel is a better way to deliver drugs through the skin for various conditions.

research Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing

4 citations , August 2023 in “Materials”

New synthetic polymers help improve skin wound healing and can be enhanced by adding natural materials and medicines.

research Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

3 citations , November 2025 in “Biomimetics”

Hydrogels show promise in preventing and treating skin damage from radiation therapy.

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