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GlossaryEpigallocatechin Gallate

powerful antioxidant in green tea with potential hair growth benefits

Epigallocatechin Gallate (EGCG) is a powerful antioxidant found predominantly in green tea. It has been studied for its potential health benefits, including anti-inflammatory, anti-cancer, and heart-protective effects. In the context of hair and alopecia, EGCG has shown promise in promoting hair growth and reducing hair loss by inhibiting the activity of hormones and enzymes that contribute to hair follicle shrinkage.

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research Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

16 citations , January 2016 in “Annals of Dermatology”

Green tea component EGCG may help prevent hair loss by changing microRNA levels in certain scalp cells.

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

research Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

7 citations , July 2022 in “Pharmaceutics”

The microneedle device with rapamycin and epigallocatechin gallate effectively promoted hair regrowth in mice.

research Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being

4 citations , September 2025 in “International Journal of Molecular Sciences”

EGCG in green tea benefits skin, hair, cancer treatment, weight loss, diabetes, heart, and brain health.

research Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review

1 citations , January 2023 in “Pharmacophore”

Tea compound EGCG may slow aging by affecting gene activity.

Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

research Paper 2. Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

October 2020 in “Journal of Pharmaceutical Sciences”

Topical finasteride with EGCG or TA improves drug release and dermal uptake, potentially treating hair loss effectively.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations , June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

research Electronic States of Epigallocatechin-3-Gallate in Water and in 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (Sodium Salt) Liposomes

3 citations , January 2025 in “International Journal of Molecular Sciences”

EGCG shows strong electron transfer interactions when bonded to DPPG lipids.

research Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

Green tea component EGCG could potentially promote human hair growth.

Epigallocatechin-3-Gallate Inhibits Paclitaxel-Induced Apoptosis Through the Alteration of MicroRNA Expression in Human Dermal Papilla Cells

research Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells

3 citations , January 2018 in “Biomedical dermatology”

Green tea extract helps prevent cell death and supports cell survival in hair cells exposed to a chemotherapy drug.

research (−)-Epigallocatechin-3-gallate promotes the dermal papilla cell proliferation and migration through the induction of VEGFA

January 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

Green tea compound EGCG may help hair growth by boosting cell activity.

research Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells

December 2018

Green tea compound EGCG could potentially treat colorectal cancer by removing iron and causing stress in cancer cells leading to their death.

research Long-Term Preservation of Rat Skin Tissue by Epigallocatechin-3-O-Gallate

6 citations , May 2009 in “Cell transplantation”

Green tea component EGCG helps keep rat skin grafts viable longer.

research Electronic States of Epigallocatechin-3-Gallate in Water and in 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (Sodium Salt) Liposomes

February 2025 in “Universidade Nova de Lisboa's Repository (Universidade Nova de Lisboa)”

research Green tea: Health benefits

86 citations , January 2008 in “Journal of nutritional & environmental medicine”

Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.

research The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

36 citations , August 2011 in “Experimental Dermatology”

Eccrine sweat gland's clear cells likely cause excessive sweating in hyperhidrosis.

research Use of natural molecules as anti-angiogenic inhibitors for vascular endothelial growth factor receptor

16 citations , December 2012 in “Bioinformation”

Curcumin, EGCG, barringtozenol, and finasteride are effective VEGFR inhibitors.

research Role and Mechanisms of Phytochemicals in Hair Growth and Health

2 citations , January 2023 in “Pharmaceuticals”

Natural products and phytochemicals may help with hair regrowth, but more research is needed.

An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

research An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

2 citations , August 2020 in “Cosmetics”

Herbal formula shows promise for hair loss treatment.

research Hair Root Activation by Anagen Grow- A Herbal Hair Growth Serum

2 citations , February 2019 in “JOJ dermatology & cosmetics”

Anagen grow, a herbal hair serum, effectively promotes hair growth and could be an alternative to finasteride and beneficial for Minoxidil users.

research Mechanically Robust MXene‐Metal Polyphenol Network Hybrid Interfaces for Multifunctional Protection of Keratin Fibers

May 2026 in “Advanced Materials Interfaces”

The new coating protects and strengthens hair while improving its properties.

research Protective Effects of Schinus terebinthifolius Leaf Supercritical Fluid Extract Against UVC-Induced Oxidative Stress: A Com-Prehensive Gene Expression Study

February 2026 in “International Journal of Molecular Sciences”

Brazilian pepper tree leaf extract effectively protects skin cells from UVC damage and is a strong natural skincare option.

research Hair growth enhancement via mitochondrial activation by Mito‐activator complex

February 2026 in “International Journal of Cosmetic Science”

The Mito-Activator Complex boosts hair growth by activating mitochondria.

research Green Tea as a Supportive Therapy for PCOS: Evaluating Its Impact on Symptom Relief

December 2025 in “Journal of Education Health and Sport”

Green tea may help relieve PCOS symptoms, but more research is needed.

research Engineered Bilayer Hydrogel with Spatiotemporal Drug and Oxygen Delivery for Diabetic Wound Microenvironment Reprogramming

December 2025 in “Regenerative Biomaterials”

The hydrogel effectively heals diabetic wounds by reducing inflammation, providing oxygen, and preventing infection.

research Phytochemicals and novel delivery systems in alopecia management: An integrative review

December 2025 in “Phytomedicine Plus”

Combining herbal medicines with modern delivery systems may improve alopecia treatment.

research Catechins-rich tea extract and its functional properties mitigating hair loss

November 2025 in “Discover Food”

Catechins-rich tea extract may help reduce hair loss and promote hair growth.

research Nitrogen‐Boosted H ₂ O ₂ Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

November 2025 in “Advanced Science”

A new nanozyme using EGCG and L-arginine boosts hair growth by safely increasing beneficial oxidative stress.

research Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study

February 2025 in “Journal of Receptors and Signal Transduction”

EGCG may help regrow hair by inhibiting a specific enzyme.

research The use of phytochemicals and other natural materials in the treatment of androgenetic alopecia

December 2024 in “NATIONS UNIVERSITY INTERNATIONAL JOURNAL OF MULTI-DISCIPLINARY STUDIES”

Natural substances like caffeine and rosemary oil may help hair growth, but more research is needed.